Rad51 (D4B10) Rabbit mAb 8875S from Cell Signaling Technology

Product Specs
ItemRad51 (D4B10) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8875S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetRad51
HostRabbit
NCBI Full Gene NameRAD51 recombinase
NCBI Gene AliasesBRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneD4B10
Molecular Weight37

Questions and Answers

Can this Rad51 antibody be used for immunofluorescence applications?

Yes, the Rad51 (D4B10) Rabbit mAb has been utilized in immunofluorescence analysis, as indicated in the literature where it was employed at a dilution of 1:500 for detecting Rad51 in various cell types ().

What specific role does Rad51 play in DNA repair, and how might this antibody be useful in studying that?

Rad51 is a crucial protein involved in homologous recombination, a key mechanism for repairing DNA double-strand breaks. The Rad51 (D4B10) antibody can be instrumental in studying DNA damage response pathways, as it allows for the detection of Rad51 expression levels and localization in cells undergoing DNA repair processes ().

Is there any evidence of this antibody being used in cancer research?

Yes, the Rad51 antibody has been cited in multiple studies related to cancer research. For instance, it was used to assess the expression of Rad51 in glioblastoma cells, highlighting its role in DNA damage response and resistance to therapy (). Additionally, it has been involved in studies examining the effects of various treatments on DNA repair mechanisms in cancer cells ().

What species can this antibody react with, and does it have broad applicability?

The Rad51 (D4B10) Rabbit mAb is reactive with multiple species, including human, mouse, rat, and non-human primates. This broad reactivity makes it suitable for a variety of experimental models in cell biology and cancer research ().

Cell Signaling Technology

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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Ixazomib triggers autophagic degradation of MUC5AC/integrin-β4 and inhibits non-small cell lung cancer progressionCancer LettersMay 1, 2026Muthamil Iniyan Appadurai, Zahraa Wajih Alsafwani, Sanjib Chaudhary, Ashu Shah, Pranay Somavarapu, Sriman N. Dooshety, Ben S. Kubicek, Surinder K. Batra, Imayavaramban Lakshmanan, Apar Kishor Ganti#2947), p27 (#3686), γH2AX (#80312), PI3K (#4249), UCHL1 (#33575), ubiquitin K-63 (#5621S) and RAD51 (#8875) were from Cell signaling Technology Inc. (MA, USA). p53 (sc-126), cyclin B1 (sc-245), and β-actin (sc-47778)

(2) Efficacy of an XPO1 inhibitor in combination with irinotecan in a preclinical colorectal cancer modelFrontiers in OncologyMarch 31, 2026Robert W. Lentz, Adrian T. A. Dominguez, Nicole Baranda Balmaceda, John J. Arcaroli, Stacey M. Bagby, Cameron A. Binns, Stephen G. Smoots, Marilyn M. Jackson, Morgan Macbeth, Tessa Holmstoen, et al.and immunocytochemistry (ICC) were acquired from Cell Signaling Technologies: RAD51 Paralog B (RAD51) (#8875), H2A histone family member X (p -H2A.X) (#9718), MutS Homolog 2 (MSH2) (#2017), TP53 (p53) (#2527),

(3) Epacadostat and Olaparib Synergistically Inhibit the Growth of BRCA-Proficient Triple-Negative Breast Cancer by Suppressing the Expression of BRCA1 and RAD51MoleculesMarch 20, 2026Lei Huang, Ye Yang, Dongxia Duan, Li Dai, Bingxin Zhai, Bingjun Qian(KeyGEN BioTECH, Nanjing, China). BRCA1 Antibody (1:1000, #9010), RAD51 (D4B10) Rabbit mAb (1:1000, #8875), anti-mouse IgG-HRP-linked antibody (1:3000, #7076), anti-rabbit IgG -HRP-linked antibody (1:3000,

(4) PRMT5 is Frequently Upregulated and a Potential Therapeutic Target in MTAP-deficient Malignant Peripheral Nerve Sheath TumorsbioRxivMarch 13, 2026Dingxun Wang, Melissa L. Fishel, Azadeh Samiei, Silpa Gampala, Changdeng Hu, Shaoxiong Chen, GuangJun Zhang(Santa Cruz Biotechnology, cat# sc-56770, RRID:AB_785534, 1:200), anti-Rad51 (Cell Signaling Technology, cat# 8875, RRID:AB_2721109, 1:1000), anti-Ku70 (Santa Cruz Biotechnology, cat# sc-17789, RRID:AB_628454, 1:1000)

(5) The Molecular and Functional Landscape of Resistance to FOLFIRI Chemotherapy in Metastatic Colorectal CancerCancer DiscoveryFebruary 6, 2026Marco Avolio, Simonetta M. Leto, Francesco Sassi, Barbara Lupo, Elena Grassi, Irene Catalano, Eugenia R. Zanella, Valentina Vurchio, Francesca Cottino, Petros K. Tsantoulis, et al.EPR13047, Abcam, #ab180170, RRID: AB_2716574), rabbit anti-RAD51 (clone D4B10, Cell Signaling Technology, #8875, RRID: AB_2721109), and mouse anti-vinculin (clone hVIN-1, Sigma-Aldrich, #V9131, RRID: AB_477629).

(6) Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination–proficient prostate cancerProceedings of the National Academy of SciencesFebruary 3, 2026Nicole A. Traphagen, Esmé Wheeler, Rong Li, Tara Akhshi, Ramya Ravindranathan, Christian Alfieri, Feng Lu, Buraq Ahmed, Alok K. Tewari, Steven P. Balk, et al.Coverslips were incubated overnight at 4 °C with primary antibodies (RAD51, Cell Signaling Technology #8875; γH2AX, Millipore #JBW301), followed by secondary antibody incubation (goat anti-mouse IgG Alexa Fluor568,

(7) Poly ADP Ribose Polymerase Inhibitors Potentiate Proton Therapy End-of-Range Effects by Accelerating Replication Forks and Promoting Transcription ConflictInternational Journal of Radiation Oncology*Biology*PhysicsFebruary 1, 2026Yiqun Han, Qin Zhou, Anna Dibbs, Bin Chen, Taylor M. Weiskittel, Nicholas B. Remmes, Zheming Wu, Daniel K. Ebner, Jake A. Kloeber, Cameron M. Callaghan, et al.(sc-56770, RRID AB_785534) for IF was purchased from Santa Cruz Biotechnology. Anti-RAD51 antibody (D4B10) (8875) for IF was purchased from Cell Signaling Technology. Anti-53BP1 antibody (sc-98) for IF was purchased

(8) Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP InhibitionCancer ResearchJanuary 9, 2026Joseph L. Sottnik, Madeleine T. Shackleford, Camryn S. Nesiba, Amanda L. Richer, Zoe Fleischmann, Jordan M. Swartz, Carmen E. Rowland, Maggie Musick, Rui Fu, Logan R. Myler, et al.(Thr543)(Cell Signaling Technology #3428; RRID:AB_2206631); RAD51 (D4B10)(Cell Signaling Technology #8875; RRID:AB_2721109); DNA-PKcs (3H6)(Cell Signaling Technology #12311; RRID:AB_2797881); phospho-DNA-PKcs

(9) Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma modelsNature CommunicationsNovember 5, 2025Connor A. Ott, Timothy J. Purwin, Pan-Yu Chen, Somenath Chowdhury, George L. Mellor, Kristine Luo, Glenn L. Mersky, Manoela Tiago, William D. Madden, Scott D. Varney, et al.and P-c-Met (Tyr1234/1235) (#3077, 1:1000), and c-Met (#8198, 1:1000), PLK1 (#4513S, 1:1000), RAD51 (#8875, 1:1000), and AXL (#8661, 1:1000) were purchased from Cell Signaling Technology. β-Gal (#Z378A, 1:1000)

(10) Elevated Transglutaminase-2 in SOX10-Deficient Melanoma Promotes Tumor Onset and Decreases Intratumoral CD4+ T CellsCancer ResearchOctober 1, 2025Signe Caksa, Timothy J. Purwin, Dan A. Erkes, Kristen M. DeRosa, Erica Kitterman, Samantha M. Barnada, Casey D. Stefanski, Haley P. Wilson, Glenn L. Mersky, McKenna Q. Glasheen, et al.phospho-ERK1/2 (#9101, RRID: AB_331646), ERK1/2 (#9102, RRID: AB_330744), GFP (#2956, RRID: AB_1196615), RAD51 (#8875, RRID: AB_2721109), p21Cip1 (#2947, RRID: AB_823586), WNT5 (#2530, RRID: AB_2215595) were purchased

(11) CF10 Displayed Improved Activity Relative to 5-FU in a Mouse CRLM Model Under Conditions of Physiological FolateCancers (Basel)August 23, 2025Charles Chidi Okechukwu, Xue Ma, Wencheng Li, Ralph D’Agostino, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, William H. Gmeinerfollowing antibodies were used in this study: Rad51 (Cell Signaling Technology, Danvers, MA, USA, Cat# 8875, RRID:AB_2721109), Chk2 (Thermo Fisher Scientific, Waltham, MA, USA, Cat# MA5-35294, RRID:AB_2849196),

(12) Combined MEK and PARP inhibition enhances radiation response in rectal cancerCell Reports MedicineAugust 19, 2025Qiyun Xiao, Julian E. Riedesser, Theresa Mulholland, Zhenchong Li, Jonas Buchloh, Philipp Albrecht, Xinchen Yang, Moying Li, Nachiyappan Venkatachalam, Olga Skabkina, et al.,Cell Signaling Technology,Cat# 4370; RRID: AB_2315112 Rabbit anti-Rad51 (D4B10),Cell Signaling Technology,Cat# 8875; RRID: AB_2721109 Rabbit anti-Phospho-Histone H2A.X (Ser139),Cell Signaling Technology,Cat# 2577; RRID:

(13) Targeting iron regulatory protein 2 (IRP2) to disrupt iron metabolism enhances radiosensitivity through mitochondrial dysfunction in breast cancer cellsCell Death DiscoveryJuly 31, 2025Ye Yeong Jeong, Jieon Hwang, Areum Park, Sungmin Cho, Inyoung Cho, Soseul Won, You Me Shin, Sung Eun Kim, Chan Hoon Maeng, Jaemoon Yang, et al.used: IRP-2 (7H6) (SC-33682, Santa Cruz, Dallas, Texas 75220 USA), CD71 (SC-32272, Santa Cruz), RAD51 (8875S, Cell Signaling, Danvers, Massachusetts, USA), LC3B (2775S, Cell Signaling), Cyclin B1 (SC-245, Santa Cruz

(14) MYC Regulates a DNA Repair Gene Expression Program in Small Cell Carcinoma of the Ovary, Hypercalcemic TypeCancers (Basel)July 7, 2025James R. Evans, Jing Wang, Cinthia N. Reed, Joy H. Creighton, Kaylee B. Garrison, Abigail N. Robertson, Ashley Lira-Rivera, Diondre’ D. Baisden, William P. Tansey, Rafet Al-Tobasei, et al.Waltham, MA, USA), SNF5 (Cell Signaling, 91735), ATR (Cell Signaling, 13934), RAD51 (Cell Signaling, 8875), and GAPDH-HRP (Cell Signaling, 8884). 2.3. Cell Proliferation and Cell Cycle Analysis For proliferation

(15) Nanoemulsion of myricetin enhances its anti-tumor activity in nude mice of triple-negative breast cancer xenograftsFront OncolJune 9, 2025Preeti Sharma, Yogesh Rai, Mohammad Ahmed Khan, Anant Narayan Bhatt, Abul Kalam Najmi, Shubhra Chaturvedi, Mohd. Akhtar, Anil Kumar Mishra(Cat#2479S), MMP-9 (Cat#13667S), Catalase (Cat#12980S), Bax (Cat#2772S), Bcl-2 (Cat#MA5-11757), RAD-51 (Cat#8875S), and Ku70 (Cat#4103S), were procured from Cell Signaling Technology (Danvers, MA, USA). Ki67 (E-AB-31869)

(16) Pimitespib, an HSP90 Inhibitor, Enhances the Efficacy of PARP Inhibitors in PARP Inhibitor-Insensitive Breast Cancer CellsCancer scienceJune 1, 2025Muraoka H, Kazuno H, Hashimoto A, Sootome H, Ohkubo S.antibody was purchased from Abcam (Cambridge, UK). Anti‐BRCA1 (#9010), anti‐BRCA2 (#10741), anti‐Rad51 (#8875), anti‐p‐histone H2A.X (#2577), anti‐p‐AKT (#4060), anti‐AKT (#4691), anticleaved PARP (#5625), and

(17) Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastomaNat CommunMay 28, 2025Lanjuan Mi, Yan Cai, Ji Qi, Lishu Chen, Yuanyuan Li, Songyang Zhang, Haowen Ran, Qinghui Qi, Cheng Zhang, Huiran Wu, et al.BRCA1 (Proteintech Group for IF, 1;200, cat#22362-1-AP), Rad51 (Cell Signaling for IF, 1:200, cat# 8875), 53BP1 (Novus for IF, 1:200, cat# NB100-304), Ubiquitin (MBL for IB, 1:1000, Cat#D058-3), Ubiquitin,

(18) Dual Disruption of DNA Repair by a Novel CHK2 Inhibitor, ART-446, and Olaparib is a Promising Strategy for Triple-Negative Breast Cancer TherapyBiomolecules & TherapeuticsMay 1, 2025Hong-Jun Kang, Young-Woo Kang, Ha-Young Lee, Sojung Ha, Jong Oh Kim, Woo-Young Kim, Taegon Baikprimary antibodies against BRCA1 (Cell Signaling, #9010, Danvers, MA, USA), RAD51 (Cell Signaling, #8875), γH2AX (Cell Signaling, #7631), pCHK2 (Thr68 or Ser516) (Cell Signaling, #2661 or #2669), pCHK1 (Ser296)

(19) Synergistic enhancement of PARP inhibition via small molecule UNI66-mediated suppression of BRD4-dependent transcription of RAD51 and CtIPNAR CancerApril 30, 2025Enkhzul Amarsanaa, Minwoo Wie, Unbeom Shin, Nabeela Bilal, Jungme Hwang, Eun A Lee, Seon Young Lee, Byung-Gyu Kim, Shinseog Kim, Yoonsung Lee, et al.following antibodies were purchased from the specified suppliers: anti-CtIP (9201S) and anti-RAD51 (8875) were obtained from Cell Signaling Technology. Anti-BRD4 (A301-985A50), anti-BRD3 (A302-368A), and anti-BRD2

(20) Milciclib-mediated CDK2 inhibition to boost radiotherapy sensitivity in colorectal cancerFrontiers in PharmacologyMarch 25, 2025Junjie Ma, Shanshan Wu, Xinxin Yang, Shuying Shen, Yiqian Zhu, Ruoqi Wang, Wei Xu, Yue Li, Haixin Zhu, Youyou Yan, et al.(#20808T), β-Actin (#4970T), PARP (#9532S), Cleaved PARP (#5625S), Bcl-2 (#3498S), Bax (#5023T), Rad51 (#8875T), Rad50 (#3427T) and GAPDH (#2118T) were purchased from Cell Signaling Technology (Danvers, MA), The

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Rad51 (D4B10) Rabbit mAb

Rad51 (D4B10) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Rad51 (D4B10) Rabbit mAb from Cell Signaling Technology

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