Smurf2 (D8B8) Rabbit mAb 12024S from Cell Signaling Technology

Product Specs
ItemSmurf2 (D8B8) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12024S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetSMURF2
HostRabbit
NCBI Full Gene NameSMAD specific E3 ubiquitin protein ligase 2
IsotypeIgG
CloneD8B8
Molecular Weight80
Research AreaDevelopmental Biology

Add to Compare List

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signalingJournal of Lipid ResearchJuly 1, 2026Xueqin Wu, Muchen Wu, Shiyu Du, Jiaxin Liu, Ruiping Wang, Yuhan Sun, Zhi Zheng, Junru Yang, Xiaowei Jia, Lulu Wang, et al.Smurf2 (D8B8),12024,CST Smad2 Rabbit mAb,19114,ABclonal Phospho-Smad2-T220 Rabbit pAb,AP0909,ABclonal Phospho-Smad3-T179

(2) The Small Chemical Compound Repsox Potentiates Oct4-Driven Astrocyte-to-Neural Stem Cell Reprogramming via Notch1/Hes1/Smurf2 PathwayCellular and Molecular NeurobiologyApril 24, 2026Xiaoyu Ma, Zijian Liu, Yuqing He, Dandan Zhang, Peng Deng, Lin Li, Xin Li, Junping Li, Quanrui Ma, Hao YangAB_1264242), rabbit anti-SYN antibody (Cat#5297, RRID: AB_2616578), rabbit anti-Smurf2 antibody (Cat#12024, RRID: AB_2797800), rabbit anti-Hes1 antibody (Cat#11988, RRID: AB_2728766), and rabbit anti-Notch1

(3) ROCK1 inhibition primes anti-tumor immunity in EGFR-mutant NSCLC by triggering PD-L1 degradation mediated by SMURF2Molecular CancerApril 2, 2026Menglin Bai, Qianqian Gao, Peng Jin, Lin Ma, Ji Li, Leilei Wu, Weiqing Wang, Luojia Lv, Yintao Li, Bo Cheng, et al.(AF3336, Affinity), Phospho GSK3β (S9) (AF2016, Affinity), Ub (P4D1) (sc-8017, Santa Cruz), SMURF2 (12024, Cell Signaling Technology), Myc-Tag (2276, Cell Signaling Technology), FLAG-Tag (2368, Cell Signaling Technology

(4) SMURF2 attenuates NRF2-driven tumor progression by acting as a nuclear brake on NRF2 during cellular stressRedox BiologyFebruary 28, 2026Wanting Xu, Lei Dong, Jiaqian Li, Shuai Fan, Yadong Wang, Qin Xia(proteintech, 16286-1-AP), anti-SMURF2 (Santa CruZ, sc-518164), anti-SMURF2 (Cell Signaling Technology, 12024), anti-NRF2 (proteintech, 16396-1-AP), anti-SQSTM1/p62 (MBL, PM045), anti-SQSTM1/p62 (Enzo life science,

(5) Tip60-HDAC8-SMURF2-mediated β-TrCP1 degradation is a key mechanism for hypoxia-induced cell death and tissue injuryCellular and Molecular Life SciencesDecember 27, 2025Sheng Li, Bo-Wen Zhang, Zi-Juan Wei, Yan Xi, Guo-An Zhang, Yue Zhang, De-Chi Kou, Xiao-Peng Song, Jing Huang, Ping Song, et al.purchased from Abcam (USA). Antibodies against SMURF2 were purchased from Cell Signaling Technology (12024, USA) and Santa Cruz Biotechnology (sc-518164, USA). Antibodies against HDAC8 were purchased from Abcam

(6) Smurf2 enhances ubiquitin-mediated degradation of CASC3 and attenuates leukemia progressioniScienceSeptember 19, 2025Ronghao Zeng, Jing Liu, Fen Lu, Ming Hong, Ting Lan, Baijian Chen, Yunping Pu, Yuwei Tan, Peter Wang, Juan Wang, et al.subsequently incubated overnight at 4°C with primary antibodies. The primary antibodies included anti-Smurf2 (#12024, Cell Signaling Technology), anti-Myc (16286-1-AP, Proteintech), anti-Flag (F1804, Sigma), anti-Tubulin

(7) Gut microbiota-derived indole-3-propionic acid alleviates diabetic kidney disease through its mitochondrial protective effect via reducing ubiquitination mediated-degradation of SIRT1Journal of Advanced ResearchJuly 1, 2025Yan Zeng, Man Guo, Qi Wu, Xiaozhen Tan, Chunxia Jiang, Fangyuan Teng, Jiao Chen, Fanjie Zhang, Xiumei Ma, Xinyue Li, et al.ubiquitin (cat. 3936, CST, USA; cat. 154650, Absin, China), MDM2 (cat. 965, Santa Cruz, USA), Smurf2 (cat. 12024, CST, USA), CUL4 (cat. 377188, Santa Cruz, USA), COP1 (cat. 166799, Santa Cruz, USA), IgG (cat. 131368,

(8) Structure–Activity Relationship Studies of DNA Methyltransferase 1 Monovalent DegradersJournal of Medicinal ChemistryFebruary 13, 2025Chao Qian, Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit, Ling Xie, Qin Chen, H. Ümit Kaniskan, Xian Chen, et al.(Cell Signaling Technology, 67259S), Nedd4 (Cell Signaling Technology, 2740), Smurf2 (Cell Signaling Technology, 12024), WWP1 (Abcam, ab43791), Uhrf1 (Cell Signaling Technology, 12387), and β-actin (Cell Signaling, 3700).

(9) SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradationCell Death DiscoveryDecember 18, 2024Fabio Bordin, Gloria Terriaca, Adriano Apostolico, Annamaria Di Fiore, Faranak Taj Mir, Sara Bellardinelli, Francesca Bufalieri, Rosa Bordone, Francesca Bellardinilli, Giuseppe Giannini, et al.Sigma-Aldrich Merck), rabbit polyclonal anti-SMURF1 (#2174; Cell Signaling), rabbit monoclonal anti-SMURF2 (#12024; Cell Signaling), rabbit polyclonal anti-GLI1(H-300) (SC-20687; Santa Cruz Biotechnology), mouse monoclonal

(10) DNA topoisomerase II inhibition potentiates osimertinib’s therapeutic efficacy in EGFR-mutant non–small cell lung cancer modelsJournal of Clinical InvestigationMay 15, 2024Zhen Chen, Karin A. Vallega, Dongsheng Wang, Zihan Quan, Songqing Fan, Qiming Wang, Ticiana Leal, Suresh S. Ramalingam, Shi-Yong Suncapecitabine, and vincristine were purchased from MedChemExpress. Topo IIα (catalog 12286), Smurf2 (catalog 12024), cPARP (catalog 5625), and Bim (catalog 2933) antibodies were purchased from Cell Signaling Technology

(11) Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1J Clin Transl HepatolMarch 28, 2024Ning Zhang, Pengyao Yang, Yanmeng Li, Qin Ouyang, Fei Hou, Guixin Zhu, Bei Zhang, Jian Huang, Jidong Jia, Anjian XuR&D Systems (Minneapolis, MN, USA); anti-SMURF1 (WH0057154M1) from Sigma (St. Louis, MO, USA); anti-SMURF2 (#12024), anti-SMAD1 (#6944), anti-FTH1 (#4393) and anti-GAPDH (#5174) from Cell Signaling Technology (Danvers,

(12) DNA topoisomerase II inhibition potentiates osimertinib’s therapeutic efficacy in EGFR-mutant non–small cell lung cancer modelsJ Clin InvestMarch 7, 2024Zhen Chen, Karin A. Vallega, Dongsheng Wang, Zihan Quan, Songqing Fan, Qiming Wang, Ticiana Leal, Suresh S. Ramalingam, Shi-Yong Suncapecitabine, and vincristine were purchased from MedChemExpress. Topo IIα (catalog 12286), Smurf2 (catalog 12024), cPARP (catalog 5625), and Bim (catalog 2933) antibodies were purchased from Cell Signaling Technology

(13) Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1J Clin Transl HepatolFebruary 4, 2024Ning Zhang, Pengyao Yang, Yanmeng Li, Qin Ouyang, Fei Hou, Guixin Zhu, Bei Zhang, Jian Huang, Jidong Jia, Anjian XuR&D Systems (Minneapolis, MN, USA); anti-SMURF1 (WH0057154M1) from Sigma (St. Louis, MO, USA); anti-SMURF2 (#12024), anti-SMAD1 (#6944), anti-FTH1 (#4393) and anti-GAPDH (#5174) from Cell Signaling Technology (Danvers,

(14) FoxO3 normalizes Smad3-induced arterial smooth muscle cell growthFrontiers in PhysiologyAugust 24, 2023Jake T. Francisco, Andrew W. Holt, Michael T. Bullock, Madison D. Williams, Cere E. Poovey, Nathan A. Holland, Jeffrey J. Brault, David A. TulisECM Biosciences); MuRF-1 (#AF5366; bio-techne); Smurf-1 (#2714; Cell Signaling Technology); Smurf-2 (#12024; Cell Signaling Technology); p21 Waf1/Cip1 (#2947; Cell Signaling Technology); p27 Kip1 (#3688; Cell Signaling Technology

(15) Smurf1 and Smurf2 mediated polyubiquitination and degradation of RNF220 suppresses Shh-group medulloblastomaCell death & diseaseAugust 3, 2023Li Y, Wang H, Sun B, Su G, Cang Y, Zhao L, Zhao S, Li Y, Mao B, Ma P.anti-ubiquitin (sc-8017, SantaCruz, 1:1000), anti-Smurf1 (2174, Cell Signaling Technology, 1:2000), anti-Smurf2 (12024, Cell Signaling Technology, 1:2000), anti-Gli1 (2534, Cell Signaling Technology, 1:2000), anti-Ptch1

(16) Activating transcription factor 4 drives the progression of diabetic cardiac fibrosisESC Heart FailureAugust 1, 2023Yu Li, Qian He, Chao‐Yong He, Chao Cai, Zhen Chen, Jing‐Zhu Duan(bs‐6353R, 1:500, Bioss), Nrf2 (bs‐1074R,1:100, Bioss), HO‐1 (BM4010, 1:500, BOSTER, Wuhan, China), Smurf2 (#12024, 1:1000, Cell Signaling Technology, Trask Lane Danvers, USA), histone H3 (A12477‐2, 1:500, BOSTER),

(17) SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferationInternational journal of biological sciencesJanuary 1, 2023Han M, Guo Y, Li Y, Zeng Q, Zhu W, Jiang J.antibodies used in this study were as follows: anti-β-actin (M1210-2; HUABio, Hangzhou, China), anti-SMURF2 (12024S; CST, Danvers, Massachusetts, USA; bs-4056R; Bioss, Beijing, China), anti-ID2 (ab166708; Abcam, China;

(18) LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 AxisOrthopaedic surgeryNovember 1, 2022Yi Y, Yang N, Yang Z, Tao X, Li Y.Rosemont, IL, USA), anti‐ONECUT2 (21916‐1‐AP, 1:600, Proteintech, Rosemont, IL, USA), anti‐Smurf2 (#12024, 1:1000, CST, USA), anti‐MMP13 (18165‐1‐AP, 1:600, Proteintech, Rosemont, IL, USA), anti‐ADAMTS5 (ab41037,

(19) The Emerging Role of E3 Ubiquitin Ligase SMURF2 in the Regulation of Transcriptional Co-Repressor KAP1 in Untransformed and Cancer Cells and TissuesCancersMarch 22, 2022Shah PA, Boutros-Suleiman S, Emanuelli A, Paolini B, Levy-Cohen G, Blank M.FLAG-KAP1 and GST-SMURF2 proteins were detected using anti-FLAG® M2 (F3165, Sigma-Aldrich) and anti-SMURF2 (12024, Cell Signaling, Danvers, MA, USA) antibodies. For the analysis of FLAG-KAP1 ubiquitination in cells

(20) Development and characterisation of SMURF2-targeting modifiersJournal of enzyme inhibition and medicinal chemistryDecember 1, 2021Manikoth Ayyathan D, Levy-Cohen G, Shubely M, Boutros-Suleiman S, Lepechkin-Zilbermintz V, Shokhen M, Albeck A, Gruzman A, Blank M.in SDS-PAGE and detected in immunoblots using the following primary antibodies: anti-SMURF2 (Cat. #12024, 1:1500; Cell Signaling, Boston, MA), anti-β-actin (Cat. #600401886, 1:3000, Rockland, Pottstown, PA),

Be the First to Write a Review!

Smurf2 (D8B8) Rabbit mAb

Smurf2 (D8B8) Rabbit mAb from Cell Signaling Technology

Description

Cell Signaling Technology

Citations (42)

Reviews

Smurf2 (D8B8) Rabbit mAb from Cell Signaling Technology

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map