Thymidylate Synthase (D5B3) XP ® Rabbit mAb 9045S from Cell Signaling Technology

Product Specs
ItemThymidylate Synthase (D5B3) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $402.00 Inquire
Catalog Number9045S
Quantity100 µl
ApplicationsW, IHC-P, IF-IC, FC-FP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetThymidylate Synthase
HostRabbit
NCBI Full Gene Namethymidylate synthetase
NCBI Gene AliasesDKCD, HST422, TMS, TS
Research AreaMetabolism
CloneD5B3
Molecular Weight30

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) CF10 Displays Improved Synergy with Oxaliplatin in TP53-Null and Wild-Type CRC Cells from Increased Top1cc and Replication StressCancers (Basel)March 9, 2026Taylor M. Young, Rida Moumouni, Akanksha Behl, Upasana Das, William H. Gmeiner(Cell Signaling Technology Cat# 6334, RRID: AB_11178526), and Thymidylate Synthase (D5B3) (Cell Signaling Technology Cat# 9045, RRID: AB_2797693) diluted in TBS-T overnight at 4 °C. Following primary antibody incubation, membranes

(2) Spatial single-cell analysis reveals tumor microenvironment signatures predictive of oral cavity cancer outcomeCell Reports MedicineFebruary 17, 2026Joni Näsiaho, Linda Nissi, Sami Ventelä, Heikki Irjala, Marko Salmi9.0 Tris/EDTA buffer (#S2367, Dako Target Retrieval). Predetermined optimal dilutions of anti-TYMS (#9045, CST, 1:200 dilution), anti-BIRC5 (#2808, CST, 1:200 dilution), and anti-BST2 (#95940, CST, 1:200 dilution)

(3) Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5FASEB BioadvDecember 12, 2025Haley Garbus-Grant, Obialunanma V. Ebenebe-Kasonde, Raihan Kabir, Mark J. Kohr(1:1000, Rabbit Ab, Cell Signaling #12762), and thymidylate synthase (1:1000, Rabbit Ab, Cell Signaling #9045). Membranes were washed with 1× Tris‐buffered saline with 0.1% Tween (TBS‐T) at room temperature and

(4) PAX3-FOXO1 Drives Targetable Cell State–Dependent Metabolic Vulnerabilities in RhabdomyosarcomaCancer ResearchDecember 1, 2025Katrina I. Paras, Julia S. Brunner, Angela M. Montero, Jacob A. Boyer, Benjamin T. Jackson, Sangita Chakraborty, Abigail Xie, Kristina Guillan, Armaan Siddiquee, Lourdes Pajuelo Pajuelo Torres, et al.(1:1000, Cell Signaling Technology, 45710; RRID:AB_3683693), anti-TYMS (1:1000, Cell Signaling Technology, 9045; RRID:AB_2797693), anti-FOXO1 (1:1000, Cell Signaling Technology, 2880; RRID:AB_2106495), anti-UCK1

(5) Vascular dementia increases levels of methylenetetrahydrofolate reductase and cystathionine β-synthase in female patients and changes gene expression of acetylcholine and glutamate clathrin-sculpted transport vesiclesbioRxivNovember 27, 2025Sanika M. Joshi, Abbey McKee, Sharadyn Ille, Kristina Buss, Thomas G Beach, Geidy E Serrano, Nafisa M. Jadavji(1:100, AbCam, Boston, MA, USA, RRID: AB_2893493), TS (1:100, Cell Signaling, Danvers, MA, USA, catalog # 9045), ChAT (1:100, Millipore Sigma, Darmstadt, Germany, RRID: AB_2079751), AChE (1:100, Millipore Sigma,

(6) Ischemic stroke increases levels of the folate receptor and one-carbon enzymes in male and female brain tissuebioRxivSeptember 11, 2025Petter Burrows, Himmat Dhillon, Gillian E. McDemott, Amanda Covaleski, Lilah Manfredi, Thomas G Beach, Geidy E Serrano, Nafisa M. JadavjiSignaling, Danvers, MA, USA, catalog # 80715), TS (1:100, Cell Signaling, Danvers, MA, USA, catalog # 9045), ChAT (1:100, Millipore Sigma, Darmstadt, Germany, RRID: AB_2079751), AChE (1:100, Millipore Sigma,

(7) Compromised C3b-VSIG4 axis between decidual NK cells and macrophages contributes to recurrent spontaneous abortionJournal of Translational MedicineNovember 11, 2024Siao Chen, Jinghe Zhang, Jian Chen, Jieqi Ke, Yu Huang, Xianghui Du, Binqing Fu, Haiming Weikit (ZSGB-Bio, cat: SAP-9100) and visualized using Fast Red chromogenic substrate (ZSGB-Bio, cat: ZLI-9045). The labeled NK cells were observed as red staining. The anti-CD68 antibody was labeled with horseradish

(8) An RNA damage response network mediates the lethality of 5-FU in colorectal cancerCell reports. MedicineOctober 15, 2024Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, et al.S345-P (1:1000),Cell Signaling Technology,2348: RRID: AB_331212 TYMS (1:1000),Cell Signaling Technology,9045:RRID: AB_2797693 PARP (1:3000),Cell Signaling Technology,9542; RRID: AB_2160739 cleaved-PARP (1:1000),Cell Signaling Technology

(9) Expression of gemcitabine metabolizing enzymes and stromal components reveal complexities of preclinical pancreatic cancer models for therapeutic testingNeoplasiaJuly 1, 2024Lisa Knoll, Jacob Hamm, Philipp Stroebel, Todorovic Jovan, Robert Goetze, Shiv Singh, Elisabeth Hessmann, Volker Ellenrieder, Christoph Ammer-Herrmenau, Albrecht NeesseCompany Inc., C15296), Podoplanin (Axxora LLC; CVL-MAB50714), HA (385911-50UG, Merck Millipore), TYMS (#9045, Cell Signaling). All antibodies were diluted 1:200 in 1 % BSA in TBST. All slides were analyzed by

(10) The E3 ubiquitin ligase NEDD4 regulates chemoresistance to 5-fluorouracil in colorectal cancer cells by altering JNK signallingCell Death DisDecember 14, 2023Sushma Anand, Christina Nedeva, Sai V. Chitti, Pamali Fonseka, Taeyoung Kang, Lahiru Gangoda, Nishat I. Tabassum, Suad Abdirahman, Thiruma V. Arumugam, Tracy L. Putoczki, et al.Cell Signaling), Caspase 3 (9662, Cell Signaling), γH2AX (9718, Cell Signaling), Thymidine synthase (9045, Cell Signaling), BCL2 (2876, Cell Signaling), Caspase 8 (ALX-804-242-C100, Enzo), β-catenin (7199,

(11) The epigenetic modifier HDAC2 and the checkpoint kinase ATM determine the responses of microsatellite instable colorectal cancer cells to 5-fluorouracilCell biology and toxicologyOctober 1, 2023Kiweler N, Schwarz H, Nguyen A, Matschos S, Mullins C, Piée-Staffa A, Brachetti C, Roos WP, Schneider G, Linnebacher M, et al.p-AKT1/p-AKT2/p-AKT3 (cs-9271; Ser473); CHK1 (cs-2360); HDAC6 (cs-7558); anti-p-Ser15-p53 (cs-9284); TS (cs-9045)), Sigma-Aldrich, Munich, Germany (acetylated tubulin (6-11B-1), T7451), BD Biosciences, Heidelberg,

(12) Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer ProgressionCancer Research CommunicationsAugust 31, 2023Anna Besschetnova, Wanting Han, Mingyu Liu, Yanfei Gao, Muqing Li, Zifeng Wang, Maryam Labaf, Susan Patalano, Kavita Venkataramani, Rachel E. Muriph, et al.CS200555), anti-E2F1 (Cell Signaling Technology, 3742), anti-GAPDH (Abcam, ab8245), anti-H3K9me1(Abcam, 9045), anti-H3K9me2 (Cell Signaling, 9753S), and anti-Tubulin (Abcam, ab6046). Chromatin Immunoprecipitation Sequencing

(13) Extracellular Leakage Protein Patterns in Two Types of Cancer Cell Death: Necrosis and ApoptosisACS OmegaJuly 18, 2023Akira Sato, Akira Shimotsuma, Tetsuya Miyoshi, Yui Takahashi, Naoki Funayama, Yoko Ogino, Akiko Hiramoto, Yusuke Wataya, Hye-Sook Kimmonoclonal antibody (EPR3507, Abcam, Cambridge, UK), anti-HMGB2 (D1P9V) rabbit monoclonal antibody (9045S, 1:1000, Cell Signaling Technologies, Massachusetts, USA), and horseradish peroxidase-linked anti-rabbit

(14) Scutellaria baicalensis enhances 5-fluorouracil-based chemotherapy via inhibition of proliferative signaling pathwaysCell Communication and SignalingJune 19, 2023Haizhou Liu, Hui Liu, Zhiyi Zhou, Jessica Chung, Guojing Zhang, Jin Chang, Robert A. Parise, Edward Chu, John C. Schmitz(obtained from Cell Signaling Inc. unless noted) were used at the indicated dilutions: anti-TS, 1:2000 (#9045); anti-E2F1, 1:1000 (#3742); anti-GAPDH, 1:10,000 (#5174; #sc-47724, Santa Cruz); anti-p-NDRG1, 1:1,000

(15) An RNA Damage Response Network Mediates the Lethality of 5-FU in Clinically Relevant Tumor TypesbioRxiv : the preprint server for biologyApril 29, 2023Chen JK, Merrick KA, Kong YW, Izrael-Tomasevic A, Eng G, Handly ED, Patterson JC, Cannell IG, Suarez-Lopez L, Hosios AM, et al.,Cell Signaling Thechology,2661 Chk1 S345-P,Cell Signaling Thechology,2348 TYMS,Cell Signaling Thechology,9045 PARP,Cell Signaling Thechology,9542 cleaved-PARP,Cell Signaling Thechology,5625 S6 S240/244-P,Cell

(16) Regulation of 5-fluorodeoxyuridine monophosphate-thymidylate synthase ternary complex levels by autophagy confers resistance to 5-fluorouracilFASEB bioAdvancesJanuary 1, 2023Nishizawa N, Kurasaka C, Ogino Y, Sato A.previously. 24 , 25 The antibodies used were rabbit anti‐thymidylate synthase (D5B3) monoclonal antibody (9045 S; 1:1000, Cell Signaling Technologies), rabbit anti‐LC3 polyclonal antibody (PM036, 1:1000; Medical

(17) dTMP imbalance through thymidylate 5'-phosphohydrolase activity induces apoptosis in triple-negative breast cancersScientific reportsNovember 21, 2022Kim DH, Kim JS, Mok CS, Chang EH, Choi J, Lim J, Kim CH, Park AR, Bae YJ, Koo BS, et al.(Santa cruz biotechnology, sc-377559), CPS2 (Santa cruz biotechnology, sc-376072), TYMS (Cell signaling technology, 9045), TK1 (Cell signaling technology, 28755), p-p70S6K(T389) (Cell signaling technology, 9205), p70S6K (Cell signaling technology

(18) Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assayâ€”Biological ImplicationsCellsOctober 19, 2022Afia Naseem, Akos Pal, Sharon Gowan, Yasmin Asad, Adam Donovan, Csilla TemesszentandrÃ¡si-Ambrus, Emese Kis, Zsuzsanna Gaborik, Gurdip Bhalay, Florence Raynaudused at 1 in 50 dilution, thymidylate synthase antibody (Cell Signaling Technology (Danvers, MA, USA), 9045) was used at 1 in 300 dilution, Adenosylhomocysteinase (AHCY) antibody (Invitrogen (Waltham, MA USA),

(19) Trapping of 5-Fluorodeoxyuridine Monophosphate by Thymidylate Synthase Confers Resistance to 5-FluorouracilACS omegaFebruary 22, 2022Kurasaka C, Nishizawa N, Ogino Y, Sato A.described.16,35 The antibodies used were rabbit anti-thymidylate synthase (D5B3) monoclonal antibody (9045S, 1:1000, Cell Signaling Technologies, Massachusetts), mouse anti-DPYD (A-5) monoclonal antibody (sc-376712,

(20) Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cellsCell reportsJanuary 11, 2022Abt ER, Le TM, Dann AM, Capri JR, Poddar S, Lok V, Li L, Liang K, Creech AL, Rashid K, et al.monoclonal",Novus Biologicals,Cat#MAB7934 "anti-TYMS, rabbit monoclonal",Cell Signaling Technology,Cat#9045; RRID:AB_2797693 Ant-RSAD2 (VIPERIN),Cell Signaling Technology,Cat#13996; RRID:AB_2734772 "anti-CLEAVED

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Thymidylate Synthase (D5B3) XP ® Rabbit mAb

Thymidylate Synthase (D5B3) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Thymidylate Synthase (D5B3) XP ® Rabbit mAb from Cell Signaling Technology

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