The Anti-Monoamine Oxidase A antibody from MyBioSource.com is a Rabbit Polyclonal antibody to mao, MAOA, and monoamine oxidase A. This antibody recognizes Human antigen. The Anti-Monoamine Oxidase A antibody has been shown to work in the following applications: Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Amine oxidase[flavin-containing] A(MAOA) detection. Tested with WB, IHC-P in Human.
Background: MAOA(Monoamine oxidase A), also known as AMINE OXIDASE(FLAVIN-CONTAINING) A, is an enzyme that in humans is encoded by the MAO-A gene. MAOA is an isozyme of monoamine oxidase which is also mapped on Xp11.3. MAOA degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the outer mitochondrial membrane. Mutation in MAOA results in monoamine oxidase deficiency, or Brunner syndrome. In humans, there is a 30-base repeat sequence repeated in one of several different numbers of times in the promoter region of the gene coding for MAOA. MAO-A levels in the brain as measured using positron emission tomography are elevated by an average of 34% in patients with major depressive disorder. Inhibition of MAOA prevented apoptosis, and serum starvation of cortical brain cells from Maoa-deficient mice resulted in reduced apoptosis compared with wildtype mice