Description
Myeloperoxidase (MPO) is a 150KDa lysosomal hemoprotein located in the azurophilic granules of neutrophils and monocytes. MPO is a dimeric protein and each dimer contains a two variable ~60-kD heavy unit and a two12-kD light subunit. MPO is responsible for the microbicidal activity of neutrophils and monocytes against a wide range of organisms. MPO exerts its activity through the production of the cytotoxic compound hypochlorous acid (HOCl) and through generation of tyrosyl radicals on invading organisms