The Anti-ATF4 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ATF4. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-ATF4 antibody has been shown to work in the following applications: Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Cyclic AMP-dependent transcription factor ATF-4(ATF4) detection. Tested with WB in Human, Mouse, Rat.
Background: ATF4, Activating Transcription Factor 4, is also know as CREB2. ATF4 belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. It is identified that members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. The ATF4 gene is mapped to chromosome 22. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the CREB2 protein