The Phospho-HER4-Y1284 Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ERBB4, and HER4. This antibody recognizes Human, Mouse, and Rat antigen. The Phospho-HER4-Y1284 Polyclonal Antibody has been shown to work in the following applications: Western Blot.
Description
The HER/ErbB receptor tyrosine kinase family has been implicated in normal development, cardiac function and cancer (1,2). HER4/ErbB4, like other family members, has four ectodomains, a single transmembrane domain and a cytoplasmic tail containing the active tyrosine kinase domain (3). By binding to neuregulins and/or EGF family ligands, ErbB4 forms either a homodimer or heterodimer with other ErbB family members, which results in receptor activation and signaling (3). ErbB4 is ubiquitously expressed with the highest expression occurring in brain and heart. The expression of ErbB4 in breast cancer, pediatric brain cancer and other types of carcinomas has been reported suggesting that ErbB4 expression is involved in both normal tissue development and carcinogenesis (3)