The GM-CSF-R-alpha (CD116) Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD116, CSF2R, CSF2RA, GM-CSF-R-alpha, and GMR. This antibody recognizes Mouse antigen. The GM-CSF-R-alpha (CD116) Antibody has been shown to work in the following applications: Immunocytochemistry, and Western Blot.
Description
Background: The granulocyte macrophage -colony-stimulating factor receptor (GM-CSF-R) is a heterodimer composed of 2 subunits,alphaand beta, and ligand binding to the high-affinity receptor leads to signalling for the multiple actions of GM-CSF on target cells. The GM-CSF receptors are found on the surface of myeloid precursors, granulocytes, mononuclear phagocyte, and also frequently present on the myeloid malignancies. The GM-CSF-R-alpha transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells