Fig 1: Schematic of the mechanism and magnificent background involved in this study. (A) Schematic of the insulin and PI3K/Akt signalling pathways. Dashed lines indicate a possible mechanism. (B) Schematic of the metabolic crosstalk between PC and skeletal muscle: ① UPS plays a key role in cancer patients’ experience of skeletal muscle loss; ② A close connection between the degree of severity of IR and progression of cancer cachexia; ③ IR exacerbates skeletal muscle degradation as cancer evolves, which produces amino acids for tumour proliferation; ④ Under the conditions of IR, overexpression of IRR and IGF-1 receptor in tumour cells promotes tumour growth.