The Mouse Anti Human B-cell Activating Factor Antibody from MyBioSource.com is a Mouse Monoclonal antibody to BAFF, CD257, and TNFSF13B. This antibody recognizes Human antigen. The Mouse Anti Human B-cell Activating Factor Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Introduction: Binds to tnfrsf13b/taci and tnfrsf17/bcma. tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response. B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays. Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin