The TSLP Receptor Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CRLF2, TSLP RECEPTOR, and TSLPR. This antibody recognizes Human, and Mouse antigen. The TSLP Receptor Antibody has been shown to work in the following applications: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
TSLP Receptor Antibody: Thymic stromal lymphopoietin (TSLP) has recently been identified as an important factor capable of driving dendritic cell maturation and activation. It is involved in the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and the induction of CD4+ T cell-mediated allergic reaction. TSLP is also capable of supporting the growth of fetal liver and adult B cell progenitors and their differentiation to the IgM-positive stage of B cell development. Its receptor TSLP-R will bind TSLP in a low-affinity fashion in transfected cells; co-transfection with IL-7R-alpha cDNA results in high-affinity binding and a functional heteromeric complex. This heteromeric receptor requires stat5 for TSLP-mediated signal transduction and is inhibited by SOCS-1