The CDIP Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Miscellaneous, and CDIP1. This antibody recognizes Human, and Mouse antigen. The CDIP Antibody has been shown to work in the following applications: ELISA, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist