MyBioSource.com's Phospho-MDM2-S260 Polyclonal Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot. The Phospho-MDM2-S260 Polyclonal Antibody was generated using Hdm2, MDM2, and MDM2 proto-oncogene as the antigen and it reacts with Human.
Description
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3)