The ASC Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ASC, PYCARD, and TMS1. This antibody recognizes Human antigen. The ASC Antibody has been shown to work in the following applications: ELISA, Immunocytochemistry, and Western Blot.
Description
ASC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues