MyBioSource.com's Rabbit anti FOXA3/HNF3G Polyclonal antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The Rabbit anti FOXA3/HNF3G Polyclonal antibody was generated using FOXA3 as the antigen and it reacts with Human, Mouse, and Rat.
Description
The forkhead box gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 plays an important role in breast cancer. The FOXA subfamily is composed of the transcription factors FOXA1, A2, A3. They were discovered as the regulators of hepatic genes. Foxa1 has been shown to be required for glucagon secretion in the pancreas, whereas Foxa2 is critical for the regulation of insulin secretion in pancreatic beta-cells. Foxa3 is important in the maintenance of glucose homeostasis, it is the dominating transcriptional regulator of GLUT2 expression in hepatocytes in vivo. In the normal activation of HNF-4alpha, HNF-1alpha, and PGC-1 induced by fasting is attenuated in mice lacking Foxa3