The Rabbit anti Desmin Polyclonal antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CSM2, DES, and Desmin. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit anti Desmin Polyclonal antibody has been shown to work in the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Desmin is a major intermediate filament protein found exclusively in striated (skeletal or cardiac) muscle tissue. It belongs to a large family of class III intermediate filament protein, the main intermediate filamentin mature skeletal, cardiac and smooth muscle cells. Mutations in the gene encoding desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. PKC (Protein Kinase C) and cAMP-dependent protein kinase can induce disassembly of the desmin filaments by phosphorylating multiple sites at N-terminus of desmin which can affect the desmin filament structure which play a role in the regulatory process in assembly and turnover