MyBioSource.com's AP-2alpha Rabbit pab Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Western Blot.
Description
Rabbit polyclonal to Human AP-2alpha
The sequence-specific transcription factor activator protein 2alpha (AP-2alpha) is required for normal growth and morphogenesis during mammalian development (1,2). Decreased or loss of AP-2alpha expression has been observed in many different types of human cancers including breast cancer (3,4), ovarian cancer (5), melanoma (6) and prostate cancer (7). These findings suggest that AP-2alpha expression plays a crucial role in tumorigenicity. Studies have also shown that p53 overexpression in human breast carcinoma cells induces the level of AP-2alpha expression. Furthermore, p53 binds to the cis-element in the AP-2alpha promoter, suggesting that AP-2alpha is a target of p53. AP-2alpha may mediate the effect of p53 to inhibit cell proliferation (8)