The Anti-TIMP3 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to K222, and TIMP3. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-TIMP3 antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Metalloproteinase inhibitor 3(TIMP3) detection. Tested with WB, ELISA in Human, Mouse, Rat.
Background: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD)