The Anti-CD3 antibody (monoclonal) from MyBioSource.com is a Mouse Monoclonal antibody to CD3E, and CD3e molecule. This antibody recognizes Human antigen. The Anti-CD3 antibody (monoclonal) has been shown to work in the following applications: Immunohistochemistry, and Immunohistochemistry - fixed.
Description
Description: Mouse IgG monoclonal antibody for CD3, CD3e molecule, epsilon (CD3-TCR complex) (CD3E) detection. Tested with IHC-F in Human. No cross reactivity with other proteins. Uniprot ID: P07766
Background: The alpha-beta heterodimeric T-cell antigen receptor binds antigen in association with major histocompatibility complex proteins on host cell surfaces. These 2 disulfide-linked glycoproteins, TCRA and TCRB are associated on T-cell surfaces with a complex of proteins called CD3(formerly T3). Human CD3 consists of at least 4 proteins: gamma, delta, epsilon, and zeta. The CD3-gamma/CD3-delta gene pair is within 300 kb of the CD3-epsilon gene and therefore these genes form a tightly linked cluster on 11q23. The clustering may be significant in terms of their simultaneous activations during T-cell development