The Anti-Human Platelet Factor 4, Purified (Clone: RTO) (Mouse IgG2b) Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CXCL4L1, and PF4V1. This antibody recognizes Human antigen. The Anti-Human Platelet Factor 4, Purified (Clone: RTO) (Mouse IgG2b) Antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. (clone RTO) is seen to bind free PF4 in the absence of any bound heparin. This is unlike (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT)