The Rabbit anti FOXA2/HNF3B Polyclonal antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human, Mouse, and Rat antigen. The Rabbit anti FOXA2/HNF3B Polyclonal antibody has been shown to work in the following applications: ELISA, and Western Blot.
Description
The forkhead box gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA1 plays an important role in breast cancer. The FOXA subfamily is composed of the transcription factors FOXA1, A2, A3. They were discovered as the regulators of hepatic genes. Regularly, the plasma insulin inhibits the forkhead transcription factor Foxa2. The cytoplasmic localization and inactivation of Foxa2 are observed in the chronic hyperinsulinaemia of insulin-resistant syndromes, thereby promoting lipid accumulation and insulin resistance in the liver. harmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes