The Anti-Cdk5 antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CDK5. This antibody recognizes Human, Mouse, and Rat antigen. The Anti-Cdk5 antibody has been shown to work in the following applications: Western Blot.
Description
Description: Rabbit IgG polyclonal antibody for Cyclin-dependent kinase 5(CDK5) detection. Tested with WB in Human, Mouse, Rat.
Background: CDK5, Cyclin-Dependent Kinase5, is also know as PSSALRE. The p34(CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle. The PSSALRE expression is in all human tissues and cell lines tested. The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35(CDK5R1). CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA