Magic™ Anti-CDKN1B (Phospho T198) polyclonal antibody CPBT-42448RH from Creative Diagnostics

Product Specs
ItemMagic™ Anti-CDKN1B (Phospho T198) polyclonal antibody
CompanyCreative Diagnostics
Price Supplier Page View Company Product Page
Catalog NumberCPBT-42448RH
Quantity100 µg
ApplicationsWB, ELISA
Conjugate/TagUnconjugated
TargetCDKN1B
FormatLiquid
HostRabbit
ModificationsPhosphorylated; phosphorylation occurs on serine, threonine and tyrosine residues. Phosphorylation on Ser-10 is the major site of phosphorylation in resting cells, takes place at the G-G phase and leads to protein stability. Phosphorylation on other sites is greatly enhanced by mitogens, growth factors, cMYC and in certain cancer cell lines. The phosphorylated form found in the cytoplasm is inactivate. Phosphorylation on Thr-198 is required for interaction with 14-3-3 proteins. Phosphorylation on Thr-187, by CDK2 leads to protein ubiquitination and proteasomal degradation. Tyrosine phosphorylation promotes this process. Phosphorylation by PKB/AKT1 can be suppressed by LY294002, an inhibitor of the catalytic subunit of PI3K. Phosphorylation on Tyr-88 and Tyr-89 has no effect on binding CDK2, but is required for binding CDK4. Dephosphorylated on tyrosine residues by G-CSF.Ubiquitinated; in the cytoplasm by the KPC complex (composed of RNF123/KPC1 and UBAC1/KPC2) and, in the nucleus, by SCF(SKP2). The latter requires prior phosphorylation on Thr-187. Ubiquitinated; by a TRIM21-containing SCF(SKP2)-like complex; leads to its degradation
IsotypeIgG
Gene NameCDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) [ Homo sapiens ]
Clonalitypolyclonal
ImmunogenSynthetic phosphopeptide (Human) from around the phosphorylation site of threonine 198 (RRRQTP)
NCBI Gene AliasesMEN4, P27KIP1, MEN1B, KIP1, CDKN4
Domain/Region/TerminusChromosome Location: 12p13.1-p12
NCBI Full Gene Namecyclin dependent kinase inhibitor 1B
ReactivityMouse, Human

Add to Compare List

Creative Diagnostics

Phone: 1-631-624-4882 (USA)
44-161-818-6441 (Europe)

Email: info@creative-diagnostics.com

Company Profile

Website: https://www.creative-diagnostics.com/

Be the First to Write a Review!

Magic™ Anti-CDKN1B (Phospho T198) polyclonal antibody from Creative Diagnostics

Creative Diagnostics

Reviews

Magic™ Anti-CDKN1B (Phospho T198) polyclonal antibody from Creative Diagnostics

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map