ASK1 (D11C9) Rabbit mAb 8662S from Cell Signaling Technology

Product Specs
ItemASK1 (D11C9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8662S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetASK1
HostRabbit
NCBI Gene AliasesASK1, MAPKKK5, MEKK5
NCBI Full Gene Namemitogen-activated protein kinase kinase kinase 5
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD11C9
Molecular Weight155

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Liangfang Wenjing decoction regulates endoplasmic reticulum stress-mediated apoptosis to alleviate uterine microvascular injury in cold-stressed ratsFrontiers in PharmacologySeptember 30, 2025Tianyuan Lv, Yue Hu, Xueyan Ma, Liqun Feng, Di Wang, Xiaodan Song, Sisi Xue, Shuai Lu, Xiumei Cheng(1:1000, 3924, CST, United States), p-IRE1α(1:1000, PA1-16927, Thermo, United States), ASK1 (1:1000, 8662, CST, United States), p-ASK1 (1:1000, MA5-36973, Thermo, United States), JNK (1:1000, 9252, CST, United

(2) Kirenol relieves rheumatoid arthritis by targeting the TWEAK/Fn14 pathwayInt J Mol MedJuly 14, 2025Zixin Chen, Jinxuan Wang, Lijuan Xiao, Zhihui Chen, Wenchuan Luo, Wen Xu, Ya Lin, Mei Huang, Yuqian Zhang, Yinghao Wang, et al.Ltd.",BM4635,WB/1:500 TRAF2,Cohesion Biosciences,CQA2285,WB/1:500 ASK1 (D11C9),"Cell Signaling Technology, Inc.",8662,WB/1:800 IKKα,ImmunoWay Biotechnology Company.,YT2302,WB/1:800 IKKα (phospho S176/177),ImmunoWay Biotechnology

(3) TIMM8B promotes oxidative phosphorylation and glycolysis by inhibiting the mtROS/ASK1/JNK signaling pathway in ovarian cancerBiol DirectJuly 1, 2025Yue Jia, Jiaqian Liao, Xiangqun Yang, Hongyan Hu, Wentao Zhao, Liufang Zhao, Conghui Ai, Yuanbo Xue, Shufen Tan, Yi ZhangComplex IV (1:1000, 4850, Cell Signaling), ATP5A (Complex V, 1:1000, ab14748, Abcam), ASK1 (1:1000, 8662S, Cell Signaling Technology), p-JNK (1:1000, AF3318, Affinity), JNK (1:1000, AF6318, Affinity), and GAPDH

(4) Differential aortic aneurysm formation provoked by chemogenetic oxidative stressJournal of Clinical InvestigationMarch 18, 2025Apabrita Ayan Das, Markus Waldeck-Weiermair, Shambhu Yadav, Fotios Spyropoulos, Arvind Pandey, Tanoy Dutta, Taylor A. Covington, Thomas MichelInvitrogen; catalog PA5-64541); ASK1 (anti-rabbit, Cell Signaling Technology; clone D11C9; catalog 8662S); Acta2 (anti-mouse, Novus Biologicals; catalog NBP2-22120); KLF4 (anti-rabbit, Proteintech; catalog

(5) Effects of the angiotensin-converting enzyme inhibitor captopril on occlusal-disharmony-induced cardiac dysfunction in miceScientific reportsNovember 15, 2023Ito A, Ohnuki Y, Suita K, Matsuo I, Ishikawa M, Mitsubayashi T, Mototani Y, Kiyomoto K, Tsunoda M, Morii A, et al.#2058), phospho-PKCδ (1:1000, Thy505, #9374), phospho-PKCδ (1:1000, Tyr311, #2055), ASK1 (1:1000, #8662), phospho-ASK1 (1:1000, Thr-845, #3765), CaMKII (1:1000, #3362), phospho-CaMKII (1:1000, Thr286, #3361),

(6) Low-intensity pulsed ultrasound of different intensities differently affects myocardial ischemia/reperfusion injury by modulating cardiac oxidative stress and inflammatory reactionFrontiers in ImmunologySeptember 7, 2023Quan Cao, Lian Liu, Yugang Hu, Sheng Cao, Tuantuan Tan, Xin Huang, Qing Deng, Jinling Chen, Ruiqiang Guo, Qing Zhouto that of the C-sham group. Primary antibodies against apoptosis signal-regulating kinase 1 (ASK1, 8662, CST, Danvers, USA), phospho-ASK1 (Ser967) (p-ASK1, 3764, CST), c-Jun N-terminal kinases (JNK, 9252,

(7) RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesisEMBO Molecular MedicineMay 8, 2023Samantha Wong, Yu Xuan Tan, Abigail Yi Ting Loh, Kiat Yi Tan, Hane Lee, Zainab Aziz, Stanley F Nelson, Engin Özkan, Hülya Kayserili, Nathalie Escande‐Beillard, et al.ERK1/2 (1:1,000 dilution, Cell Signaling, 4695, RRID:AB_390779), ASK1 (1:500 dilution, Cell Signaling, 8662, RRID:AB_11220434) and pASK1 (1:1,000 dilution, Cell Signaling, 3765, RRID:AB_2139929), JNK (1:1,000

(8) ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in ratsMolecular medicine reportsFebruary 1, 2023Duan J, Yuan W, Jiang J, Wang J, Yan X, Liu F, Liu A.(Ser-83; 1:1,000; cat. no. MA5-28020; Thermo Fisher Scientific, Inc.), anti-ASK1 (1:1,000; cat. no. 8662; Cell Signaling Technology, Inc.), anti-p-p38 MAPK (Thr180/Tyr182) (1:1,000; cat. no. 9216; Cell Signaling Technology

(9) Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 SignalResearch (Washington, D.C.)January 1, 2023Xia K, Wang T, Chen Z, Guo J, Yu B, Chen Q, Qiu T, Zhou J, Zheng S.(19677-1-AP, Proteintech; 1:1000), anti-p-ASK1 (#3764, Cell Signaling Technology; 1:1000), anti-ASK1 (#8662, Cell Signaling Technology; 1:1000), anti-GAPDH (10494-1-AP, Proteintech; 1:5000), anti-Flag (GB11938,

(10) Vidarabine, an anti-herpes agent, prevents occlusal-disharmony-induced cardiac dysfunction in miceThe Journal of Physiological SciencesDecember 1, 2022Yoshio Hayakawa, Kenji Suita, Yoshiki Ohnuki, Yasumasa Mototani, Misao Ishikawa, Aiko Ito, Megumi Nariyama, Akinaka Morii, Kenichi Kiyomoto, Michinori Tsunoda, et al.phospho-p38 (1:1000, Thr-180/Tyr-182, #4511), apoptosis signal-regulatory kinase 1 (ASK1) (1:1000, #8662) and phospho-ASK1 (1:1000, Thr-845, #3765) were purchased from Cell Signaling Technology (Boston, MA,

(11) MicroRNA-23a-5p Is Involved in the Regulation of Lipopolysaccharide-Induced Acute Lung Injury by Targeting HSP20/ASK1Oxidative Medicine and Cellular LongevityAugust 11, 2021Yi-Fei Chen, Fen Hu, Xian-Guo Wang, Zheng Tang, He-Xiao Tang, Ming Xup10 (#sc-56036, Santa Cruz), anti-TXNIP (#ab188865, Abcam), anti-p-ASK1 (#3765, CST), anti-t-ASK1 (#8662, CST), anti-p-p38 (#4511, CST), anti-t-p38 (#8690, CST), and antiheat shock protein 20 (HSP20; #ab184161,

(12) IRE1α RIDD activity induced under ER stress drives neuronal death by the degradation of 14-3-3 θ mRNA in cortical neurons during glucose deprivationCell death discoveryJune 3, 2021Gómora-García JC, Gerónimo-Olvera C, Pérez-Martínez X, Massieu L.(1:1000, Cell Signaling, 9252); p-SAPK/JNK (1:3000, Cell Signaling, 9251); ASK1 (1:1000, Cell Signaling, 8662); p-ASK1 (1:1000, Cell Signaling, 3764); CHOP (1:500, Santa Cruz Biotechnology, sc-7351); BAK (1:1000,

(13) Paeoniflorin inhibits the macrophage-related rosacea-like inflammatory reaction through the suppressor of cytokine signaling 3-apoptosis signal-regulating kinase 1-p38 pathwayMedicineJanuary 22, 2021Liu Z, Zhang J, Jiang P, Yin Z, Liu Y, Liu Y, Wang X, Hu L, Xu Y, Liu W.antibodies were used: anti-SOCS3 (1:1000, 52113 s), anti-p38 (1:1000, 8690 s), and anti-ASK1 (1:1000, 8662 s) from Cell Signaling Technology (Beverly, MA, USA); anti-TLR2 (1:1000, ab16894) anti-LL37 (1:1000,

(14) Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo StudyFrontiers in pharmacologyJanuary 1, 2021Yan J, Zhang Y, Sheng G, Ni B, Xiao Y, Wang S, Wang T, Ma Y, Wang H, Wu H, et al.R&D systems (MN, United States). Antibodies specific for P-P65 (#3003), COX2 (#12882), P-ASK1 (#3764), ASK1 (#8662), P-P38 (#4511), P38 (#8690), P-JNK (#9255), JNK (#9258), P-IκBα (#5209) were purchased from Cell Signaling Technology

(15) FBXW7 regulates epithelial barrier impairment in human bronchial epithelial cells in vitro by targeting apoptosis signal-regulating kinase1 via the p38 pathwayBIOCELLJanuary 1, 2021JINGRONG SONG, JUAN KANG, WEI LV, YAN DONG, XIAOYING ZHANGfrom Santa Cruz Biotechnology Inc (CA, USA) were used. Anti-FBXW7 (ab109617, Abcam) and anti-ASK1 (#8662, CST) antibodies were applied for IP detection. Anti-FBXW7 (ab105752), antiZO-1 (ab190085), anti-E-cadherin

(16) Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra via Regulating ASK-1/TNF-α ComplexFrontiers in NeuroanatomyJuly 24, 2020Zhang Feng, Liu Jie, Lv Guimin, Wang Ximembrane was incubated overnight with one of the following antibodies at 4°C: anti-ASK-1 antibody (8662, Cell Signaling Technology), anti-pASK-1 antibody (3764, Cell Signaling Technology), anti-STRAP antibody

(17) MicroRNA-494 represses osteosarcoma development by modulating ASK-1 related apoptosis complexesTranslational Cancer ResearchJuly 1, 2020Gan Gao, Yuekui Jianmembrane was incubated with one of the following antibodies overnight at 4 °C: anti-ASK-1 antibody (8662, Cell Signaling Technology), anti-phospho-ASK-1 antibody (3764, Cell Signaling Technology), anti-STRAP

(18) Identification of interferon-stimulated genes that attenuate Ebola virus infectionNature communicationsJune 11, 2020Kuroda M, Halfmann PJ, Hill-Batorski L, Ozawa M, Lopes TJS, Neumann G, Schoggins JW, Rice CM, Kawaoka Y.PFKFB3 (1:1000, 13132, Cell signaling technology), ODC1 (1:1000, TA501546, Origene), MAP3K5 (1:1000, 8662, Cell signaling technology), AKT3 (1:1000, 3788, Cell signaling technology), GBP2 (1:1000, TA500657,

(19) Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injuryThe Journal of clinical investigationMay 1, 2020Nakamura K, Kageyama S, Kaldas FM, Hirao H, Ito T, Kadono K, Dery KJ, Kojima H, Gjertson DW, Sosa RA, et al.Histone H3 (4499/D1H2), cleaved caspase-3 (9664/5A1E), RIP3 (95702/D4G2A), CC1 (14771/D1P4T), ASK1 (8662/D11C9), p-p38 (4511/D3F9), Vinculin (VCL) (18799/E1E9V), and β-actin (12620/D6A8, Cell Signaling Technology)

(20) ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury modelJCI insightJanuary 30, 2020Schuster-Gaul S, Geisler LJ, McGeough MD, Johnson CD, Zagorska A, Li L, Wree A, Barry V, Mikaelian I, Jih LJ, et al.Cell Signaling Technology, catalog 3765), anti-ASK1 (D11C9) (1:1000, Cell Signaling Technology, catalog 8662), anti–P-p38 (Thr180/Tyr182) (1:1000, Cell Signaling Technology, catalog 9211), anti–p38 MAP kinase

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ASK1 (D11C9) Rabbit mAb

ASK1 (D11C9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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ASK1 (D11C9) Rabbit mAb from Cell Signaling Technology

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