MKK3 (D4C3) Rabbit mAb 8535S from Cell Signaling Technology

Product Specs
ItemMKK3 (D4C3) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8535S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetMKK3
HostRabbit
NCBI Gene AliasesMAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2
NCBI Full Gene Namemitogen-activated protein kinase kinase 3
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD4C3
Molecular Weight38-40

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) S-Nitrosylation of the Scaffold Protein STRAP Enhances Oxidative Stress–Induced ApoptosisJournal of Biological ChemistryJanuary 8, 2026Weixiong Xu, Daniel Chen, Hua-Lin ZhouRestore PLUS Western Blot Stripping Buffer (Thermo Scientific) for 10 min and reblocked with antibodies rabbit anti-MKK3 (8535S; 1:1000 dilution) and anti-p38 (8690S; 1:1000 dilution) from Cell Signaling Technology. Immunoprecipitation To

(2) Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart.Journal of Molecular and Cellular Cardiology PlusDecember 1, 2025Reo Matsumura, Mototsugu Nishii, Haruya Usuku, Masahiro Nakayama, Masaki Hachisuka, Naho Misawa, Ryo Saji, Fumihiro Ogawa, Alan Valaperti, Yoshihiro Ishikawa, et al.were from Novus Biologicals (Cat. #: NBP1–88192), Cell Signaling Technology (Cat. #: 9211, 9212, 9236, 8535, and 8550), Santa Cruz Biotechnology (Cat. sc-136,548 and 8008), and Cell Signaling Technology (Cat.

(3) Targeting MKK3/c-Myc interaction to overcome osimertinib acquired resistance in EGFR mutant lung cancerCancer LettersNovember 1, 2025Zhen Chen, Karin A. Vallega, Dongsheng Wang, Elsa Bildtsen, Haian Fu, Suresh S. Ramalingam, Andrey A. Ivanov, Shi-Yong SunMAPK (#8690), phospho-p38 MAPK (Thr180/Tyr182; #4511), c-Myc (#9402), p-c-Myc (S62; #13748), MKK3 (#8535) and p-MKK3 (S189; #12280), respectively, for Western blotting and immunoprecipitation (IP) were purchased

(4) Broad-spectrum inflammasome inhibition by thiomuscimolCell Death DiscoveryNovember 16, 2024Marisa J. Anderson, Andreas B. den Hartigh, Wendy P. Loomis, Susan L. Finkanti-mouse RD680 secondary antibody (LiCor). MEK3 was detected with rabbit monoclonal MEK3 antibody (#8535 s, Cell signaling technologies) and donkey anti-rabbit secondary antibody IR Dye 680 RD (LiCor). Blots

(5) Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axisAmerican journal of physiology. Lung cellular and molecular physiologyOctober 1, 2024Valuparampil Varghese M, James J, Bharti D, Rischard F, Rafikova O, Rafikov R.P-MAPKAPK-2 (T334) (1:1,000, 3041), HSP27 (1:1,000, 2402S), p-HSP27(1:1,000, 2401S), MKK3 (1:1,000, 8535S), Phospho-STAT3 (Ser727) (1:1,000, 9134S), STAT3 (1:1,000, 9139S), Phospho-Akt (Ser473) (1:1,000, 4060S),

(6) Variations in candidalysin amino acid sequence influence toxicity and host responsesmBioAugust 14, 2024Don N. Wickramasinghe, Claire M. Lyon, Sejeong Lee, Olivia W. Hepworth, Emily L. Priest, Corinne Maufrais, Adam P. Ryan, Emmanuelle Permal, Derek Sullivan, Brenda A. McManus, et al.reference candidalysin (variant A)-treated cells. Antibodies Primary antibodies specific for MKK3 (#8535), MKK6 (#8550), p-MKK3/6 (MKK3-Ser189 and MKK6-Ser207; #12280), p-EGFR Y1068 (#3777S), c-Fos (#2250S),

(7) Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase LCell ReportsApril 23, 2024Jiajia Xi, Goda Snieckute, José Francisco Martínez, Frederic Schrøder Wenzel Wenzel Arendrup, Abhishek Asthana, Christina Gaughan, Anders H. Lund, Simon Bekker-Jensen, Robert H. Silverman,Cell Signaling Technology,9231 RRID:AB_2140799 MKK3(D4C3) Rabbit Monoclonal Antibody,Cell Signaling Technology,8535 RRID:AB_11220233 Phospho-SEK1/MKK4(Ser 257/Thr261) Antibody,Cell Signaling Technology,9156 RRID:AB_2297420 SEK1/MKK4 Antibody

(8) MKK3 K329 Mutation Attenuates Diabetes-Associated Cognitive Dysfunction by Blocking the MKK3-RAGE Interaction and Inhibiting Neuroinflammationaging and diseaseFebruary 25, 2024Changjiang Ying, Yan Li, Shidi Wu, Lin Gao, Yandong Zhu, Ye Qian, Xiangru Wen, Hui Li, Chengyu Huang, Bin Hu, et al.Mouse Anti-RAGE (Santa Cruz Biotechnology, sc-365154), Rabbit Anti-MKK3 (Cell Signaling Technology, 8535), Mouse Anti-Caspase-1 (Adipogen, AG-20B-004), Rabbit Anti-IL-1β (Proteintech, 16806-1-AP), Rabbit Anti-TNF-α

(9) Interruption of p38MAPK-MSK1-CREB-MITF-M pathway to prevent hyperpigmentation in the skinInternational Journal of Biological SciencesFebruary 17, 2024Song-Hee Kim, Jiyeon Lee, Jihye Jung, Ga Hyun Kim, Cheong-Yong Yun, Sang-Hun Jung, Bang Yeon Hwang, Jin Tae Hong, Sang-Bae Han, Jae-Kyung Jung, et al.(Cell Signaling Technology, 3489); anti-p-MKK3/6 (Cell Signaling Technology, 9236); anti-MKK3/6 (Cell Signaling Technology, 8535); anti-tyrosinase (TYR)-related protein-1 (TRP-1; Santa Cruz Biotechnology, sc-10446); and anti-dopachrome

(10) KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancerJournal of cellular and molecular medicineJune 1, 2023Cai C, Yao S, Zou Y, Lu H, Chen X, Wang Y, Zheng K, Zhu F, Wang Y, Xiong H, et al.(1:500, PA5‐43209, Invitrogen), anti‐phos‐MEKK1 (1:500, PA5‐12755, Invitrogen), anti‐MKK3 (1:1000, #8535, CST), anti‐phos‐MKK3 (1:1000, #12280, CST), anti‐p38 (1:1000, #8690, CST), anti‐phos‐p38 (1:1000, #4511,

(11) The ubiquitination status of the glucagon receptor determines signal biasThe Journal of biological chemistryMay 1, 2023Kaur S, Sokrat B, Capozzi ME, El K, Bai Y, Jazic A, Han B, Krishna Kumar K, D'Alessio DA, Campbell JE, et al.anti-ERK1/2 (catalog no. 9102), Rabbit polyclonal anti-phospho p38 (catalog no. 9102), MKK3 (catalog no. 8535), TAB1 (catalog no. 3226), STAMBP (catalog no. 5245), rabbit polyclonal Myc tag (catalog no. 2272),

(12) A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid LeukemiaJournal of medicinal chemistrySeptember 22, 2022Marín-Rubio JL, Peltier-Heap RE, Dueñas ME, Heunis T, Dannoura A, Inns J, Scott J, Simpson AJ, Blair HJ, Heidenreich O, et al.purchased from Cell Signaling Technology (Danvers): MK2 (#3042), Thr-334-P-MK2 (#3041), MK3 (#7421), MKK3 (#8535), Ser189-P-MKK3/Ser207-P-MKK6 (#12280), p38 MAPK (#9212), p38α MAPK (#9218), p38γ MAPK (#2307), Thr180/Tyr182-P-p38

(13) RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathwayHuman CellJuly 1, 2022Rui Guo, Shun-Yuan Lu, Jin-Xia Ma, Qian-Lan Wang, Lu Zhang, Ling-Yun Tang, Yan Shen, Chun-Ling Shen, Jin-Jin Wang, Li-Ming Lu, et al.RIG-I (1:1000, D14G6, Cell Signaling, USA), P-MKK3 (1:1000, 12,280, Cell Signaling, USA), MKK3 (1:1000, 8535, Cell Signaling, USA), P-MKK4 (1:1000, 4514, Cell Signaling, USA), MKK4 (1:1000, 9152, Cell Signaling,

(14) A potent tumor-selective ERK pathway inactivator with high therapeutic indexPNAS NexusJuly 1, 2022Zuo Z, Liu J, Sun Z, Silverstein R, Zou M, Finkel T, Bugge TH, Leppla SH, Liu S.western blotting using anti-MEK1 (#07–641, Upstate Technology), -MEK2 (#67410, Proteintech), -MEK3 (#8535, Cell Signaling), -MEK4 (#67333, Proteintech), -MEK6 (#8550, Cell Signaling), MEK-7 (#4172, Cell Signaling),

(15) Serum Pharmacochemistry Combining Network Pharmacology to Discover the Active Constituents and Effect of Xijiao Dihuang Tang Prescription for Treatment of Blood-Heat and Blood-Stasis Syndrome-Related DiseaseOxidative Medicine and Cellular LongevityFebruary 7, 2022Yuxin Chen, Yang Dai, Jie Xia, Jing Liu, Guisheng Zhou, Cuihua Chen, Baoping Jiang, Lian Yin, Guochun LiAbcam, Cambridge, UK, catalogue number: ab131283), MKK-3 (1 : 1000, CST, Boston, USA, catalogue number: 8535), Phos-MKK-6 (1 : 500, BIOTECHNOLOGY, CA, USA, catalogue number: A7154), MKK-6 (1 : 1000, CST, catalogue

(16) Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling PathwayAntioxidants (Basel, Switzerland)January 19, 2022Ko J, Jang S, Kwon W, Kim SY, Jang S, Kim E, Ji YR, Park S, Kim MO, Choi SK, et al.MAPK (#8690), p-B-Raf (#14814), B-Raf (#2696), p-MEK (#9154), MEK (#9126), p-MKK3/6 (#12280), MKK3 (#8535), #MKK6 (#8550), GAPDH (#5174; Cell Signaling Technology, Danvers, MA, USA), cyclin A1 (ab53699), Nox1

(17) Title: p38δ Regulates IL6 Expression Modulating ERK Phosphorylation in PreadipocytesFrontiers in Cell and Developmental BiologyJanuary 17, 2022Selene Díaz-Chamorro et al.(Cell Signaling #4668, 1:1,000), anti-JNK (Cell Signaling #9252, 1:1,000), anti-MKK3 (Cell Signaling #8535, 1:1,000), anti-MKK6 (Cell Signaling #9264, 1:1,000), anti-pERK1/2 (Cell Signaling #9101, 1:1,000),

(18) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine productionCell death & diseaseOctober 23, 2021Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, et al.3042), phospho-MK2 (T334) (CST,3007), p38 (CST, 9212), phospho-p38 (CST, 4511; CST, 9216), MKK3 (CST, 8535), MKK6 (CST, 8550), phospho-MKK3/MKK6 (CST, 12280), IKK (CST, 8943S), phospho-IKK (CST, 2078S), RIPK3

(19) PP1C and PP2A are p70S6K Phosphatases Whose Inhibition Ameliorates HLD12-Associated Inhibition of Oligodendroglial Cell Morphological DifferentiationBiomedicinesApril 16, 2020Matsumoto N, Miyamoto Y, Hattori K, Ito A, Harada H, Oizumi H, Ohbuchi K, Mizoguchi K, Yamauchi J.Molecular Pharmacology, National Research Institute for Child Health and Development, Setagaya, Tokyo 157-8535, Japan Laboratory of Cell Signaling, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo

(20) Incremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged miceInternational journal of molecular medicineNovember 1, 2019Bao C, Yang Z, Cai Q, Li Q, Li H, Shu B.temperature. The PVDF membranes were sequentially incubated with primary antibodies against MKK3 (cat. no. 8535; Cell Signaling Technology, Inc.), phosphorylated (p)-MKK3 (cat. no. 12280; Cell Signaling Technology,

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MKK3 (D4C3) Rabbit mAb

MKK3 (D4C3) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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MKK3 (D4C3) Rabbit mAb from Cell Signaling Technology

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