MKK6 (D31D1) Rabbit mAb 8550S from Cell Signaling Technology

Product Specs
ItemMKK6 (D31D1) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8550S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetMKK6
HostRabbit
NCBI Gene AliasesMAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
NCBI Full Gene Namemitogen-activated protein kinase kinase 6
Research AreaMAP Kinase Signaling
IsotypeIgG
CloneD31D1
Molecular Weight38

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Atypical p38 Kinase Signaling in Retinal Vascular Damage and RecoveryFASEB JDecember 31, 2025Lillian Schulz, Abby E. Young, Fang Liu, Sanjana Gattineni, Sneha S. Ghosh, Eugene Douglass, Heike Kroeger, S. Priya Narayanan, Neil J. Grimseyanti‐phospho‐MKK3/6 (Cell Signaling Technologies, #9231S), and Rabbit anti‐total‐MKK6 (Cell Signaling Technologies, #8550S), Donkey anti‐Rabbit IgG Alexa Fluor 488 (Invitrogen, # A‐20216), Donkey anti‐Mouse IgG (H + L) Alexa

(2) Coxsackie and adenovirus receptor is a novel regulator of inflammatory response in endotoxin-induced failing heart.Journal of Molecular and Cellular Cardiology PlusDecember 1, 2025Reo Matsumura, Mototsugu Nishii, Haruya Usuku, Masahiro Nakayama, Masaki Hachisuka, Naho Misawa, Ryo Saji, Fumihiro Ogawa, Alan Valaperti, Yoshihiro Ishikawa, et al.Novus Biologicals (Cat. #: NBP1–88192), Cell Signaling Technology (Cat. #: 9211, 9212, 9236, 8535, and 8550), Santa Cruz Biotechnology (Cat. sc-136,548 and 8008), and Cell Signaling Technology (Cat. #9339, 4505,

(3) Small Molecule Targeting of Atypical p38 Protects Against Viral InfectionFASEB JOctober 31, 2025Fredejah T. Royer, Jeremy C. Burton, Johnathan Burns, Megan G. Lloyd, Reuben Onwe, Jennifer F. Moffat, Neil J. GrimseyGrakoui (Emory University), anti‐GAPDH (GeneTex, ID# GT239), anti‐MKK6 (Cell Signaling Technology, ID# 8550S), anti‐p‐MKK3/6 (Cell Signaling Technology ID# 9231S), HRP‐conjugated goat–anti‐rabbit (BioRad, ID#

(4) A novel human specific lncRNA MEK6-AS1 regulates adipogenesis and fatty acid biosynthesis by stabilizing MEK6 mRNAJ Biomed SciJanuary 8, 2025Di Li, Yunhua Chen, Xingyu Zhu, Yanlei Yang, Hongling Li, Robert Chunhua ZhaoProteintech, Wuhan, China), FABP4 (1:20000, 12802-1-AP, Proteintech), PLIN1(1:1000, 9349S, CST), MEK6(1:1000, 8550S, CST), GAPDH (1:10000, 10494-1-AP, Proteintech) overnight at 4 °C, and then incubated with HRP–conjugated

(5) Variations in candidalysin amino acid sequence influence toxicity and host responsesmBioAugust 14, 2024Don N. Wickramasinghe, Claire M. Lyon, Sejeong Lee, Olivia W. Hepworth, Emily L. Priest, Corinne Maufrais, Adam P. Ryan, Emmanuelle Permal, Derek Sullivan, Brenda A. McManus, et al.candidalysin (variant A)-treated cells. Antibodies Primary antibodies specific for MKK3 (#8535), MKK6 (#8550), p-MKK3/6 (MKK3-Ser189 and MKK6-Ser207; #12280), p-EGFR Y1068 (#3777S), c-Fos (#2250S), and p-MKP1

(6) RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m6A modificationSignal Transduction and Targeted TherapyJune 2, 2023Yahui Zhao, Yang Li, Rui Zhu, Riyue Feng, Heyang Cui, Xiao Yu, Furong Huang, Ruixiang Zhang, Xiankai Chen, Lei Li, et al.9211), p38 MAPK (1:1000, Cell Signaling Technology; 9218), MKK6 (1:1000, Cell Signaling Technology; 8550), β-actin (1:1000, Cell Signaling Technology; 4970), Flag-tag (1:5000, Immunoway; YM3001), Myc-tag (1:5000,

(7) Anti‑oncogenic and pro‑myogenic action of the MKK6/p38/AKT axis induced by targeting MEK/ERK in embryonal rhabdomyosarcomaOncology reportsSeptember 1, 2022Di Rocco A, Camero S, Benedetti A, Lozanoska-Ochser B, Megiorni F, Marchese C, Stramucci L, Ciccarelli C, Bouché M, Bossi G, et al.Santa Cruz Biotechnology, Inc.); anti MKK6-PO4 D8E9 (MEK3/6) (cat. no. 12280; 1:1,000), anti-MKK6 D31D1 (cat. no. 8550; 1:1,000), anti-AKT-PO4 Thr308 (cat. no. 4056; 1:1,000), anti-AKT-PO4 Ser473 (cat. no. 9271; 1:1,000)

(8) EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progressioniScienceAugust 19, 2022Gonzalez ME, Naimo GD, Anwar T, Paolì A, Tekula SR, Kim S, Medhora N, Leflein SA, Itkin J, Trievel R, et al.(Lys27),Cell Signaling,Cat #9733; RRID:AB_2616029 Rabbit Monoclonal anti-MKK6,Cell Signaling,Cat #8550; RRID:AB_11220227 Rabbit Monoclonal anti-HA-Tag,Cell Signaling,Cat #3724; RRID:AB_1549585 Mouse Monoclonal

(9) A potent tumor-selective ERK pathway inactivator with high therapeutic indexPNAS NexusJuly 1, 2022Zuo Z, Liu J, Sun Z, Silverstein R, Zou M, Finkel T, Bugge TH, Leppla SH, Liu S.Technology), -MEK2 (#67410, Proteintech), -MEK3 (#8535, Cell Signaling), -MEK4 (#67333, Proteintech), -MEK6 (#8550, Cell Signaling), MEK-7 (#4172, Cell Signaling), anti-P-ERK (#4695, Cell Signaling), -P-p38 (#4511,

(10) Cyclin B/CDK1 and Cyclin A/CDK2 phosphorylate DENR to promote mitotic protein translation and faithful cell divisionNature communicationsFebruary 3, 2022Clemm von Hohenberg K, Müller S, Schleich S, Meister M, Bohlen J, Hofmann TG, Teleman AA.for flow cytometry: 1:100, mouse, Cell Signaling #9706 S), MAP2K6 (WB: 1:1000, IF: 1:500, rabbit, Cell Signaling #8550), MCTS1 (1:1000, guinea pig, in-house production) a-raf (1:1000, rabbit, Cell Signaling #4432), c-raf

(11) Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling PathwayAntioxidants (Basel, Switzerland)January 19, 2022Ko J, Jang S, Kwon W, Kim SY, Jang S, Kim E, Ji YR, Park S, Kim MO, Choi SK, et al.p-B-Raf (#14814), B-Raf (#2696), p-MEK (#9154), MEK (#9126), p-MKK3/6 (#12280), MKK3 (#8535), #MKK6 (#8550), GAPDH (#5174; Cell Signaling Technology, Danvers, MA, USA), cyclin A1 (ab53699), Nox1 (ab131088; Abcam),

(12) Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine productionCell death & diseaseOctober 23, 2021Zu R, Yu Z, Zhao J, Lu X, Liang W, Sun L, Si C, Zhu K, Zhang T, Li G, et al.(T334) (CST,3007), p38 (CST, 9212), phospho-p38 (CST, 4511; CST, 9216), MKK3 (CST, 8535), MKK6 (CST, 8550), phospho-MKK3/MKK6 (CST, 12280), IKK (CST, 8943S), phospho-IKK (CST, 2078S), RIPK3 (Homemade), phospho-RIPK3

(13) Hsp70 Interacts with Mitogen-Activated Protein Kinase (MAPK)-Activated Protein Kinase 2 To Regulate p38MAPK Stability and Myoblast Differentiation during Skeletal Muscle RegenerationMolecular and cellular biologyDecember 15, 2018Fan W, Gao XK, Rao XS, Shi YP, Liu XC, Wang FY, Liu YF, Cong XX, He MY, Xu SB, et al.Cell Signaling Technology included the following: anti-pp38MAPK (4511), anti-MKK3 (8535), anti-MKK6 (8550), anti-ASK (3762), anti-AKT, antiPI3K, anti-MK2 (7421), anti-MK3 (3043), and anti-JNK (9252). Antibodies

(14) Caspase-3 suppresses diethylnitrosamine-induced hepatocyte death, compensatory proliferation and hepatocarcinogenesis through inhibiting p38 activationCell Death & DiseaseMay 11, 2018Na Shang, Thomas Bank, Xianzhong Ding, Peter Breslin, Jun Li, Baomin Shi, Wei Qiup-JNK (9255), NF-κB (8242), p-NF-κB (3033), p38 (8690), p-p38 (4631), p-MK2 (3007), MKK3 (8535), MKK6 (8550), p-MKK3/6 (12280), were purchased from Cell Signaling Technologies (Danvers, MA). TUNEL staining TUNEL

(15) BYD Ameliorates Oxidative Stress-Induced Myocardial Apoptosis in Heart Failure Post-Acute Myocardial Infarction via the P38 MAPK-CRYAB Signaling PathwayFrontiers in PhysiologyMay 8, 2018Yi Zhang, Chun Li, Hui Meng, Dongqing Guo, Qian Zhang, Wenji Lu, Qixin Wang, Yong Wang, Pengfei TuCell Signaling Technology, Germany), anti-phospho MKK 3/MKK6 (9236; Cell Signaling Technology, Germany), anti-MKK6 (8550; Cell Signaling Technology, Germany), anti-phospho P38 MAPK (4511; Cell Signaling Technology, Germany),

(16) GSK3 is a negative regulator of the thermogenic program in brown adipocytesScientific reportsFebruary 22, 2018Markussen LK, Winther S, Wicksteed B, Hansen JB.p-GSK3β (Ser9) (#5558), p38 MAPK (#9212), p-p38 MAPK (Thr180/Tyr182) (#9211), MKK3 (#8535), MKK6 (#8550), p-MKK3/6 (Ser189/Ser207) (#12280), ATF2 (#9226), p-ATF2 (Thr71) (#5112), HSL (#4107), p-HSL (Ser660)

(17) Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing TetraploidizationEBioMedicineFebruary 1, 2018Yeung YT, Yin S, Lu B, Fan S, Yang R, Bai R, Zhang C, Bode AM, Liu K, Dong Z.MKK3 (Cell Signaling Technology Cat# 8535S, RRID:AB_1122023), MKK6 (Cell Signaling Technology Cat# 8550S, RRID:AB_1122022), p-Stat3 (Tyr705) (Cell Signaling Technology Cat# 9145, RRID:AB_2491009), Stat3 (Cell Signaling Technology

(18) Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signalingPLoS pathogensOctober 1, 2017Seshadri S, Allan DSJ, Carlyle JR, Zenewicz LA.Cell Signaling Technology 9125 MKK3 Rabbit Cell Signaling Technology 5674 MKK6 Rabbit Cell Signaling Technology 8550 ERK1/2 Rabbit Cell Signaling Technology 4695 Phosphorylated ERK1/2 (Thr202/Tyr204) Rabbit Cell Signaling Technology

(19) Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophagesScience SignalingSeptember 1, 2016Anna M. Piccinini, Lorena Zuliani-Alvarez, Jenny M. P. Lim, Kim S. Midwood(#4370), human pp38α (#9211), human phosphorylated MKK3/MKK6 (#12280), human MKK3 (#8535), human MKK6 (#8550, Cell Signaling Technology), mouse 4G10 Platinum anti-phosphotyrosine (#05-1050, Millipore), rabbit

(20) miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cellsNature communicationsAugust 16, 2016Rasmussen MH, Lyskjær I, Jersie-Christensen RR, Tarpgaard LS, Primdal-Bengtson B, Nielsen MM, Pedersen JS, Hansen TP, Hansen F, Olsen JV, et al.p38α/MAPK14 (1:500, Santa Cruz Biotechnologies, SC-81621), MAP2K6/MKK6 (1:500–1:1,000, Cell Signaling, #8550), MXI1 (1:200, Santa Cruz Biotechnologies, SC-1042), IRAK2 (1:1,000, Cell Signaling, #4367), phospho-Thr180/Tyr182-p38α/MAPK14

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MKK6 (D31D1) Rabbit mAb

MKK6 (D31D1) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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MKK6 (D31D1) Rabbit mAb from Cell Signaling Technology

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