Estrogen Receptor alpha (H222) Antibody sc-53492 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemEstrogen Receptor alpha (H222) Antibody
CompanySanta Cruz Biotechnology, Inc.
Price $316.00Supplier Page View Company Product Page
Catalog Numbersc-53492
NCBI Gene AliasesESTRR, NR3A1, ESR, Estra, ERalpha, ERa, Estr, ESRA, Nr3a1, ER-alpha, ER, Era
Antibody TypePrimary Antibodies
Quantity200 µg/ml
CloneH222
ApplicationsWB
Reactivitymouse, rat, human
Conjugate/TagUnconjugated
Hostrat
FormatPurified
ClonalityMonoclonal
NCBI Full Gene Nameestrogen receptor 1 (alpha), estrogen receptor 1
TargetEstrogen Receptor alpha
IsotypeIgG1

Questions and Answers

Can this antibody be used for detecting Estrogen Receptor alpha in human samples?

Yes, the Estrogen Receptor alpha (H222) Antibody has been shown to react with human samples, as well as mouse and rat samples, making it suitable for studies involving human tissues.

What applications has this antibody been cited in?

The Estrogen Receptor alpha (H222) Antibody has been cited in scientific literature specifically for use in Western Blot applications, indicating its effectiveness in detecting the target protein in various experimental setups.

Is this antibody suitable for use in cancer research?

Yes, this antibody is categorized under cancer markers and has been utilized in studies related to cancer, particularly those investigating the role of estrogen receptors in tumor biology.

What is the clonality of this antibody, and how might that affect its use in experiments?

The Estrogen Receptor alpha (H222) Antibody is a monoclonal antibody. Monoclonal antibodies typically provide high specificity and consistency in experiments, which can enhance the reliability of results in applications such as Western Blotting.

Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) The SARS-CoV-2 spike protein binds and modulates estrogen receptorsbioRxiv : the preprint server for biologyMay 23, 2022Solis O, Beccari AR, Iaconis D, Talarico C, Ruiz-Bedoya CA, Nwachukwu JC, Cimini A, Castelli V, Bertini R, Montopoli M, et al.Spike Protein (1:100, Invitrogen, #MA5–36087) + rat anti-ERα H222 (1:100, Santa Cruz Biotechnology, #sc53492) overnight at 4°C. After rinsing 3 × 10 min in PB, sections were incubated in a cocktail of the corresponding

(2) Dual-mechanism estrogen receptor inhibitorsProceedings of the National Academy of Sciences of the United States of AmericaAugust 31, 2021Min J, Nwachukwu JC, Min CK, Njeri JW, Srinivasan S, Rangarajan ES, Nettles CC, Sanabria Guillen V, Ziegler Y, Yan S, et al.

(3) Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancerJournal of lipid researchDecember 1, 2018Maczis MA, Maceyka M, Waters MR, Newton J, Singh M, Rigsby MF, Turner TH, Alzubi MA, Harrell JC, Milstien S, et al.

(4) Full antagonism of the estrogen receptor without a prototypical ligand side chainNature chemical biologyJanuary 1, 2017Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, et al.

(5) Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female miceNeurobiology of agingMarch 1, 2014Zhang J, Yang L, Lin N, Pan X, Zhu Y, Chen X.

(6) Neuropeptidase activity is down-regulated by estradiol in steroid-sensitive regions of the hypothalamus in female miceNeuropeptidesAugust 1, 2012Bruce LA, Cyr NE, Qiao JW, Defries CC, Tetel MJ, Wolfson AJ.

(7) Nuclear Thimet oligopeptidase is coexpressed with oestrogen receptor alpha in hypothalamic cells and regulated by oestradiol in female miceJournal of neuroendocrinologyAugust 1, 2010Cyr NE, Kua LH, Bruce LA, Chadwick JG, Tetel MJ, Wolfson AJ.

(8) Clomiphene citrate elicits estrogen agonistic/antagonistic effects differentially via estrogen receptors alpha and betaEndocrine journalJanuary 1, 2010Kurosawa T, Hiroi H, Momoeda M, Inoue S, Taketani Y.