Ku70 (D10A7) Rabbit mAb 4588S from Cell Signaling Technology

Product Specs
ItemKu70 (D10A7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4588S
Quantity100 µl
ApplicationsW
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetKu70
HostRabbit
NCBI Gene AliasesCTC75, CTCBF, G22P1, KU70, ML8, TLAA
NCBI Full Gene NameX-ray repair cross complementing 6
Research AreaCell Cycle / Checkpoint Control
IsotypeIgG
CloneD10A7
Molecular Weight70

Add to Compare List

Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Functional effects of EpCAM N-glycosylation in MDA-MB-468 breast cancer cellsScientific ReportsFebruary 20, 2026Nicole M. Jenkinson, Harsh Oza, Kevin J. Yarema, Kristine Glunde(1:500 dilution, Sigma Aldrich #T5168); anti-Ku70 antibody (1:500 dilution, Cell Signaling Technology #4588S, Danvers, MA, USA); anti-EGFR antibody (1:2,000 dilution, Proteintech #66455-1-Ig, Rosemont, IL, USA);

(2) The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTDNature CommunicationsDecember 20, 2025Yong-Woo Jun, Soojin Lee, Sandra Almeida, Kristine K. Freude, Justin K. Ichida, Fen-Biao Gaosc-5280, 1:1000), XRCC6/Ku70 (Santa Cruz Biotechnology, sc-17789, 1:1000 and Cell Signaling Technology, 4588S, 1:1000), Phosphorylated H2AX (Sigma, 05-636, 1:1000; Cell Signaling Technology, 9718S; Santa Cruz Biotechnology,

(3) ARID1A stabilizes non-homologous end joining factors at DNA breaks induced by the G4 ligand pyridostatinCell ReportsSeptember 23, 2025Susana Simões-Sousa, Noa Amin, Karen A. Lane, Alison Harrod, Malin Pedersen, Mercedes Pardo, Christine Rasetti-Escargueil, Zuzanna Kozik, Katheryn A.G. Begg, Alison Ribeiro, et al.AB_2939025 DNA Ligase IV/LIG4 (D5N5N),Cell Signaling,14649S; RRID: AB_2750871 Ku70 (D10A7),Cell Signaling,4588S; RRID: AB_11179211 Ku80 (C48E7),Cell Signaling,2180S; RRID: AB_2218736 PAXX/C9orf142,Abcam,ab126353;

(4) Ubiquitin-specific protease 15 interacts directly with the HSV-1 alkaline nuclease and facilitates viral recombination and replication fork stabilityJournal of VirologySeptember 23, 2025Yee Vue, Patrick J. Mullon, Alexander Leehangin, Emiliano Maldonado-Luevano, Tyler D. Hasselmann, Kavi P. M. Mehta, Kareem N. MohniMilliporeSigma 11867423001), and rabbit monoclonal anti-Ku70 D10A7 (1:5,000; Cell Signaling Technologies 4588). Quantification and statistical analysis Statistical analyses were completed using Prism. An ANOVA

(5) BQ323636.1 Employs the AR-CCRK Axis to Modulate the Expression of KU70 to Interfere with Non-Homologous End Joining Mediated DNA Repair Mechanism †CellsAugust 29, 2025Ho Tsoi, Zi-Qing So, Ellen P. S. Man, Chan-Ping You, Koei Ho-Lam Cheung, Yin-Suen Tse, Wing-Lok Chan, Ui-Soon KhooMA, USA), anti-DNA-PKcs (1:4000; #4602, Cell Signaling Technology, Danvers, MA, USA), KU70 (1:1000; #4588, Cell Signaling Technology, Danvers, MA, USA), anti-CCRK (1:1000; ab252986, Abcam Limited, Cambridge

(6) Phosphorylated Y14 condensates as a scaffold for DNA double-strand break repairiScienceAugust 15, 2025Su CH, Chuang TW, Yeh HH, Shen CL, Hung PY, Li Y, Tarn WY.,BD Biosciences,Cat# 611072; RRID: AB_398385 Rabbit monoclonal anti-Ku70,Cell Signaling Technology,Cat# 4588; RRID: AB_11179211 Rabbit polyclonal anti-RBM8A (Y14),GeneTex,Cat# 131387; RRID: AB_2886473 Rabbit

(7) Prostaglandin E2 and Progesterone Receptor Coordinately Regulate Primary Cilia for Proper DecidualizationFASEB journal : official publication of the Federation of American Societies for Experimental BiologyAugust 15, 2025Lee CJ, Tsai YC, Chen TY, Chao YY, Lin RC, Tsai HL, Wen JY, Tang TK, Tsai PY, Kuo PL, et al.anti‐CEP164 (NBP1‐81445, Novus, CO, USA). The following antibodies are used as internal controls: anti‐ku70 (#4588, Cell Signaling), anti‐beta tubulin (GTX101279, GeneTex), and anti‐GAPDH (CAB0004, Cyrusbioscience,

(8) Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibitionNature communicationsJuly 30, 2025Mukherjee S, Garda C, Boffa L, Elia AR, Massara M, Balia MT, Brina D, Mosole S, Campagnari A, Cassanmagnago GA, et al.anti-pChk1 (Ser345) (133D3) (2348 s, 1:1000 dilution, Cell signaling), rabbit monoclonal anti-Ku70 (D10A7) (4588 s, 1:1000 dilution, Cell signaling), rabbit monoclonal anti-Ku80 (C48E7) (2180 s, 1:1000 dilution, Cell signaling

(9) Lyophilized apoptotic vesicles restore DNA damage and mitochondria dysfunction to ameliorate radiation enteritisJ NanobiotechnologyJuly 16, 2025Bo Yang, Huigen Luo, Xutong Yan, Lingzhi Li, Zhiqing Huang, Yexiang Jiang, Xueli Mao, Songtao Shi, Lan MaProteintech Group (Rosemont, IL, USA). Anti-rabbit γH2AX (9718 S), anti-rabbit Annexin V (8555s), anti-rabbit Ku70 (4588 S), anti-mouse PCNA (2586 S), anti-rabbit PARP (9532 S), anti-rabbit calreticulin (12238 S) and anti-mouse

(10) γ-tubulin mediates DNA double-strand break repairJournal of Cell ScienceMarch 15, 2025Abhishikt David Solomon, Odjo G. Gouttia, Ling Wang, Songli Zhu, Feifei Wang, Yanqui Li, Mohammadjavad Paydar, Tadayoshi Bessho, Benjamin H. Kwok, Aimin Peng1:1000), anti-RAD51 (D4B10, #8875, 1:800), anti-DNA-PKcs (E6U3A, #38168, 1:1000), anti-Ku70 (D10A7, #4588, 1:1000), anti-RPA70 (#2267, 1:1000), anti-DNA ligase IV (D5N5N, #14649, 1:1000), anti pATM/ATR substrate

(11) LINC01235 Promotes Clonal Evolution through DNA Replication Licensing‐Induced Chromosomal Instability in Breast CancerAdvanced ScienceFebruary 14, 2025Qi Zhang, Xuliren Wang, Zhibo Shao, Yi Zhang, Liyi Zhang, Ming Chen, Xujie Zhou, Han Zhu, Yue Zhou, Xinya Lu, et al.RPA32 (Cell Signaling, 10 148, 1:1000), XRCC5 (Cell Signaling, 2180, 1:1000), XRCC6 (Cell Signaling, 4588, 1:1000), phospho‐DNA‐PKcs (Cell Signaling, 68 716, 1:1000), DNA‐PKcs (Cell Signaling, 36 168, 1:1000),

(12) Role of the NuRD complex and altered proteostasis in cancer cell quiescencebioRxivFebruary 14, 2025Qi J Jiang, Michelle Ertel, Austin Arrigo, Sara Sannino, Jennifer L. Goeckeler-Fried, April Sagan, Betsy Ann Varghese, Daniel D. Brown, Wayne Stallaert, Adrian Lee, et al.anti-LC3B (Proteintech, 18725–1-AP), 1:1000 ATG5 (Cell Signaling, 2630), 1:1000 Ku70 (Cell Signaling, 4588) in 5% milk overnight at 4°C. After washing with TBST three times (10 minutes each), membranes were

(13) Melanophilin-induced primary cilia promote pancreatic cancer metastasisCell Death DisJanuary 16, 2025Yu-Ying Chao, Ruei-Ci Lin, Ping-Jui Su, Chu-An Wang, Ting-Yuan Tu, Ya-Chin Hou, Yi-Tzui Tsai, I-Chen Peng, Shaw-Jenq Tsai, Yan-Shen Shan, et al.anti-ERK (#4695), anti-MMP2 (#40994), anti-E-cadherin (#3195), anti-N-cadherin (#13116), anti-Ku70 (#4588), anti-Rab27a (#69295), anti-CX43 (#3512), anti-GSK3α/β (#5676), anti-p-JNK (#4668), anti-JNK (#9252),

(14) Exploring the role of PARP1 inhibition in enhancing antibody–drug conjugate therapy for acute leukemias: insights from DNA damage response pathway interactionsJournal of Translational MedicineNovember 26, 2024Andrea Ghelli Luserna di Rorà, Mouna Jandoubi, Antonella Padella, Anna Ferrari, Andrea Marranci, Cristina Mazzotti, Francesco Olimpico, Martina Ghetti, Lorenzo Ledda, Maria Teresa Bochicchio, et al.CHK1 (#37010); CHK2 (#2662); WEE1 (#13,084); BRCA1 (#9010); BRCA2 (#10741); PALB2 (#30253); KU70 (#4588); XLF (#2854); PCNA (#13110); PARP1 (#9542); CCNB1 (#4138); pCDK1Tyr15 (#9111); pH2AXSer139 (#2577);

(15) TRIM24 Cooperates with Ras Mutation to Drive Glioma Progression through snoRNA Recruitment of PHAX and DNA‐PKcsAdvanced ScienceAugust 1, 2024Chenxin Xu, Guoyu Chen, Bo Yu, Bowen Sun, Yingwen Zhang, Mingda Zhang, Yi Yang, Yichuan Xiao, Shi‐Yuan Cheng, Yanxin Li, et al.(1:1000, #9649), anti‐H3K4me3 (1:1000, #9751), anti‐DNA‐PKcs (1:1000, #12 311), anti‐Ku70 (1:1000, #4588), anti‐Ku80 (1:1000, #2753), anti‐HA Tag (1:1000, #3724), anti‐Vimentin (1:800 for IHC, #5741), anti‐CD68

(16) DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repairNucleic acids researchJune 24, 2024Li P, Gai X, Li Q, Yang Q, Yu X.methods Materials These following antibodies were purchased from respective company: anti-Ku70 (CST, 4588; Santa Cruz, sc-1486), anti-Ku80 (CST, 2180; Santa Cruz, sc-1484), anti-DNA-PKcs (CST, 38168; Thermo Fisher

(17) Apigenin protects against ischemic stroke by increasing DNA repairFrontiers in PharmacologyApril 30, 2024Niu Ping, Kuiyang Zuo, Jiahan Cai, Chunshu Rong, Ziqiao Yu, Xu Zhang, Gaihua Wang, Chunyu Ma, Huirong Yang, Jinhua Li, et al.anti Caspase3 (1:1000, CST: #9661), anti-Cytochrome c (1:1000, CST: #4272), anti-KU70 (1:1000, CST: #4588), anti-BRCA1 (1:1000, abcam: ab238983), and anti-RAD51 (1:1000, CST: #8875). Subsequently, the membranes

(18) Bleomycin induces senescence and repression of DNA repair via downregulation of Rad51Molecular MedicineApril 22, 2024Fuqiang Chen, Wenna Zhao, Chenghong Du, Zihan Chen, Jie Du, Meijuan ZhouMre11 (#4895), Rad51 (#8875), RPA2 (#35869), DNA-PKcs (#4602), Ligase IV (#14649), Ku80 (#2180), Ku70 (#4588), E2F1 (#3742), γH2AX (#2577) and β-actin (#4967). These antibodies were sourced from Cell Signaling Technology

(19) Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibitionScience signalingApril 9, 2024Ribeiro CF, Rodrigues S, Bastos DC, Fanelli GN, Pakula H, Foiani M, Zadra G, Loda M.P95/NBS1 (CST, 14956); Vinculin (Sigma Aldrich, V9131); p-eIF2a (CST, 9721), Ku80 (CST, 2753); Ku70 (CST, 4588); DNA Ligase IV (CST, 14649); CERS2 (Abcam, ab176709); puromycin (Sigma Aldrich, MABE343); c-PARP (CST,

(20) Toxoplasma gondii infection-induced host cellular DNA damage is strain-dependent and leads to the activation of the ATM-dependent homologous recombination pathwayFront Cell Infect MicrobiolMarch 8, 2024Lisbeth Rojas-Barón, Carlos Hermosilla, Anja Taubert, Zahady D. Velásquez,Cell Signalling,14956,Rabbit,1:1000 DNA-PKcs,Cell Signalling,38168,Rabbit,1:1000 Ku70,Cell Signalling,4588,Rabbit,1:1000 Artemis (D708V),Cell Signalling,13381,Rabbit,1:1000 DNA ligase IV,Cell Signalling,14649,Rabbit,1:1000 Vinculin,Santa Cruz

Write a Review

(1)

2/6/2019Time Course Effect Of Chemoattractant On Ku70 Expression Somasundaram RaghavanKu is an abundunt, ubiquitously expresssed heterodimeric protein helps to binds to DNA double-strand break ends and is required for the non-homologous end joining pathway for DNA repair. It is ... Read Review

Ku70 (D10A7) Rabbit mAb

Ku70 (D10A7) Rabbit mAb from Cell Signaling Technology

Description

Cell Signaling Technology

Citations (61)

Reviews

Ku70 (D10A7) Rabbit mAb from Cell Signaling Technology

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map