alpha-Actinin (D6F6) XP ® Rabbit mAb 6487S from Cell Signaling Technology

Product Specs
Itemalpha-Actinin (D6F6) XP ® Rabbit mAb
CompanyCell Signaling Technology
Price $371.00 Inquire
Catalog Number6487S
Quantity100 µl
ApplicationsW, IF-IC
ReactivityH, M, R, Mk
TargetACTN1
IsotypeIgG
HostRabbit
NCBI Gene AliasesBDPLT15
NCBI Full Gene Nameactinin alpha 1
CloneD6F6
Molecular Weight100
ClonalityMonoclonal
Research AreaCytoskeletal Signaling

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expressionJCI InsightApril 22, 2026Yan Tang, Stanislovas S. Jankauskas, Li Liu, Xujun Wang, Alus M. Xiaoli, Fajun Yang, Gaetano Santulli, Daorong Feng, Jeffrey E. Pessin(2132S), ParkinSer65 (36866S), troponin I (13083S), VDAC (4866S), ubiquitin (43124S), and α-actinin-1 (6487S) from Cell Signaling Technology; Parkin (702785) and PACRG (PA5-110069) from Thermo Fisher Scientific;

(2) Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline MetabolismAdvanced ScienceJanuary 31, 2026Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping LiangSOX2 (Abcam, ab171380, 1:200), TNNT2 (Abcam, ab8295, 1:500), α‐Actinin (Cell Signaling Technology, 6487P, 1:100), Cx43 (Santa Cruz Biotechnology, sc‐271837, 1:200; Abcam, ab11370, 1:500), and SNAT2 (Santa Cruz Biotechnology

(3) Cdh2, a downstream target of Hes7, regulates somitogenesis by supporting FGF signallingDevelopmentSeptember 1, 2025Xueqi Jia, Akihiro Isomura, Ryoichiro Kageyamaanti-Cdh2 (Cell Signaling Technology, 13116) and rabbit anti-a-actinin (Cell Signaling Technology, 6487). Secondary antibodies were HRP-conjugated anti-rabbit antibodies (GE Healthcare, NA9340-1ML). For detecting

(4) FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum‐Selective Autophagy in CardiomyocytesJournal of the American Heart AssociationAugust 19, 2025Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. TruttmannA7811; Sarcomeric cardiomyocyte staining and western blotting), alpha‐actinin (D6F6; Cell Signaling, 6487T, Rabbit mAb; cardiac fibroblast staining), BiP (Proteintech, 665741IG, mouse mAb), CHOP (D46F1; Cell Signaling

(5) FICD (FIC Domain Protein Adenylyl Transferase) Deficiency Protects Mice From Hypertrophy‐Induced Heart Failure and Promotes BiP (Binding Immunoglobulin Protein) ‐Mediated Activation of the Unfolded Protein Response and Endoplasmic Reticulum‐Selective Autophagy in CardiomyocytesJ Am Heart AssocAugust 18, 2025Shannon M. Lacy, Rebecca J. Taubitz, Nicholas D. Urban, Samantha N. Turowski, Eric N. Primack, Eric D. Smith, Adam S. Helms, Daniel E. Michele, Matthias C. TruttmannA7811; Sarcomeric cardiomyocyte staining and western blotting), alpha‐actinin (D6F6; Cell Signaling, 6487T, Rabbit mAb; cardiac fibroblast staining), BiP (Proteintech, 665741IG, mouse mAb), CHOP (D46F1; Cell Signaling

(6) CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selectionbioRxivAugust 1, 2025Jan-Hannes Schäfer, Austin Calza, Keenan Hom, Puneeth Damodar, Ruizhi Peng, Nebojša Bogdanović, Gabriel C. Lander, Scott M. Stagg, Michael A. CianfroccoTgn38,11605,24712*,CST,10718,21567,GS-GN,11139,14587* AP2 Heparin,11604,24711,RNAPol-III,10168,4180,FAsyn,10470,4578* Pks13,11608,26574,RAG1-2,10049,6487,Cas7-11,11268,14848* MSG,11167,34029,N2ase,11795,26764*,T20S,10025,6287* Aldolase,10379,21492*,PRex-1G,10285,20308*,CDK,10561,12042 MAVS,10031,6428,HA-trimer,10097,8731,7TM-1G,10288,0339 Publicly

(7) PD-1/PD-L1 inhibitor treatment associated with cardiotoxicity regulated by macrophage polarization and SOCS3/JAK/STAT3 signaling pathwayCentral European Journal of ImmunologyApril 9, 2025Jiding Fu, Ge Wang, Lisi Zeng, Jie Lin, Yier Wei, Wei Xu, Rui Xu, Lewu Xiancell nuclei. The sections were also co-stained with α-actinin (1 : 100; Cell Signaling Technology, #6487) and the associated Alexa Fluor 647-conjugated secondary antibody (1 : 200; Abcam, #ab150075) to confirm

(8) Genetic and Molecular Characterization of H9c2 Rat Myoblast Cell LineCellsMarch 28, 2025Liehr T, Kankel S, Hardt KS, Buhl EM, Noels H, Keller DT, Schröder-Lange SK, Weiskirchen R.Antibody,Cat. no.,Company,Dilution,Clonality α-Actinin 1,6487,"Cell Signaling Technology, Leiden, The Netherlands",1:1000,r mAb α-Actinin 2,A7811,"Sigma-Aldrich,

(9) Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1αMol MedMarch 14, 2025Yafen Chen, Shuyao Shan, Qiqi Xue, Yan Ren, Qihong Wu, Jiawei Chen, Ke Yang, Jiumei Cao9475), Hif-1α (Cat# 36,169), cleaved caspase-3 (Cat# 9661), total caspase-3 (Cat# 9662), α-actin (Cat# 6487), and β-actin (Cat# 3700) were obtained from Cell Signaling Technology (MA, USA). The Phd3 antibody

(10) Cell migration signaling through the EGFR-VAV2-Rac1 pathway is sustained in endosomesJournal of Cell ScienceJanuary 15, 2025Itziar Pinilla-Macua, Sachin Surve, Alexander SorkinGAPDH (#2118), EGFR (#4267), Akt (#9272), EGFR pTyr992 (#2235), EGFR pTyr1173 (#4407) and α-actinin (#6487) were from Cell Signaling Technology. Antibodies against VAV2 (sc-271442) and β-actin (sc-8432) were

(11) Macrophage-derived S100A9 promotes diabetic cardiomyopathy by disturbing mitochondrial quality control via STAT3 activationInternational journal of biological sciencesJanuary 1, 2025Huo S, Wang M, Du M, Ren B, Yang T, Peng L, Jiang Y, Peng D, Men L, Shi W, et al.previously described15. The primary antibodies used were listed as follows: S100A9 (#73425), α-actinin (#6487), STAT3 (#12640), pSTAT3 (Tyr705, #9145), DRP1 (#8570), pDRP1 (Ser616, #4494), and MFF (#84580) were

(12) Rad‐mediated inhibition of CaV1.2 channel activity contributes to uterine artery haemodynamic adaptation to pregnancyThe Journal of PhysiologyDecember 1, 2024Xiang‐Qun Hu, Rui Song, Chiranjib Dasgupta, Taiming Liu, Meijuan Zhang, Stephen Twum‐Barimah, Arlin B. Blood, Lubo Zhangtarget protein abundance was normalized to the abundance of alpha-Actinin (D6F6) (Cell Signaling, Cat # 6487S) or succinate dehydrogenase (SDHA) (Cell Signaling, Cat # 11998) (1:1000000) as a protein loading control. Statistical

(13) Rad-mediated inhibition of CaV1.2 channel activity contributes to uterine artery hemodynamic adaptation to pregnancyJ PhysiolNovember 29, 2024Xiang-Qun Hu, Rui Song, Chiranjib Dasgupta, Taiming Liu, Meijuan Zhang, Stephen Twum-Barimah, Arlin B. Blood, Lubo Zhangtarget protein abundance was normalized to the abundance of alpha-Actinin (D6F6) (Cell Signaling, Cat # 6487S) or succinate dehydrogenase (SDHA) (Cell Signaling, Cat # 11998) (1:1000000) as a protein loading control. Statistical

(14) Endogenous retroviral ERVH48-1 promotes human urine cell reprogrammingCell regeneration (London, England)September 13, 2024Peng Y, Zhu J, Zhang Q, Zhang R, Wang Z, Ye Z, Ma N, Qin D, Pei D, Li D.MAP2 (invitrogen, 13–1500), NEUN (abcam, ab177487), TNNT2 (BD Pharmingen, 565,744), α-acti nin (CST, 6487S), Goat anti-Mouse Alexa Fluor™ 568 (invitrogen, A-11004), Goat anti-Rabbit Alexa Fluor™ 568 (invitrogen,

(15) In situ administration of STING-activating hyaluronic acid conjugate primes anti-glioblastoma immune responseMaterials Today BioJune 1, 2024Teenesha Chellen, Mathilde Bausart, Pierre Maus, Kevin Vanvarenberg, Nisha Limaye, Véronique Préat, Alessio Malfanti(Vilber Lourmat). The following primary antibodies were used: Alpha-actinin at 1/1000 (Cell Signaling, 6487); GAPDH at 1/1000 (Cell Signaling, 2118); STING at 1/1000 (Cell Signaling, 13647); pSTING at 1/500 (Cell Signaling

(16) Tumor-associated macrophage subtypes on cancer immunity along with prognostic analysis and SPP1-mediated interactions between tumor cells and macrophagesPLOS GeneticsApril 22, 2024Liu Xu, Yibing Chen, Lingling Liu, Xinyu Hu, Chengsi He, Yuan Zhou, Xinyi Ding, Minhua Luo, Jiajing Yan, Quentin Liu, et al.primary rabbit antibodies to anti-osteopontin antibody (1:1000, ab214050, Abcam) or anti-ACTB (1:1000, 6487S, Cell Signaling Technology) at 4°C overnight. Subsequently, the membrane was washed with TBST three

(17) Apolipoprotein L1 is a tumor suppressor in clear cell renal cell carcinoma metastasisFrontiers in OncologyApril 12, 2024Linh Nguy-Hoang Le, Cheolwon Choi, Jae-A. Han, Eun-Bit Kim, Van Ngu Trinh, Yong-June Kim, Seongho Ryu(4061), Snail (3879), Slug (9585), Integrin αV (4711), Integrin β3 (4702), p-FAK (8556), α-actinin (6487), p-Talin (5426), GAPDH (2118) from Cell Signaling (USA); Vinculin (sc-25336) from Santacruz (USA).

(18) Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolismJournal of molecular cell biologyApril 4, 2024Jiang Q, Wang N, Lu S, Xiong J, Yuan Y, Liu J, Chen S.used in this study were: rabbit monoclonal anti-α-Actinin antibody, 1:2000 (Cell Signaling Technology, 6487); rabbit polyclonal anti-Ceruloplasmin antibody, 1:1000 (Thermo Fisher Scientific, PA5-14225); mouse

(19) Synergistic Anticancer Activity of Plumbagin and Xanthohumol Combination on Pancreatic Cancer ModelsInternational journal of molecular sciencesFebruary 16, 2024Palanisamy R, Indrajith Kahingalage N, Archibald D, Casari I, Falasca M.(#4060), Phospho-Akt (T308) (#4056), Phospho-Stat3 (Y705) (#9138), total Stat3 (#9139), and Actinin (#6487), the latter used as a loading control. The following day, membranes were incubated with HRP-conjugated

(20) BioE3 identifies specific substrates of ubiquitin E3 ligasesNature CommunicationsNovember 23, 2023Orhi Barroso-Gomila, Laura Merino-Cacho, Veronica Muratore, Coralia Perez, Vincenzo Taibi, Elena Maspero, Mikel Azkargorta, Ibon Iloro, Fredrik Trulsson, Alfred C. O. Vertegaal, et al.follows: Cell Signaling Technology: anti-biotin-HRP (1/1000; Cat#7075 S), anti-alpha-Actinin (1/5000; Cat#6487S), anti-PCM1 (1/1000; Cat#5213S); SinoBiological: anti-BirA (1/1000; Cat#11582-T16); Proteintech: anti-USP9X

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alpha-Actinin (D6F6) XP ® Rabbit mAb

alpha-Actinin (D6F6) XP ® Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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alpha-Actinin (D6F6) XP ® Rabbit mAb from Cell Signaling Technology

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