CHD1 (D8C2) Rabbit mAb 4351S from Cell Signaling Technology

Product Specs
ItemCHD1 (D8C2) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number4351S
Quantity100 µl
ApplicationsW, IP, ChIP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetCHD1
HostRabbit
NCBI Full Gene Namechromodomain helicase DNA binding protein 1
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD8C2
NCBI Gene AliasesCHD-1, PILBOS
Molecular Weight220

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Natural panax notoginseng-derived nanovesicles trigger multiple cell death mechanisms and reprogram chemokine signaling to impede oral squamous cell carcinoma progressionJournal of NanobiotechnologyMarch 6, 2026Xiaohang Chen, Meifang Lin, Xuzheng Zhan, Genggeng Zheng, Shuoqi Lin, Liyu Huang, Chaochao Zhang, Yuxiang Yan, Hengyi Li, Zhaoyu Zhang, et al.(#9212), phospho-p38 MAPK (#4511), JNK (#9252), phospho-JNK (#4668), SNAIL (#3879), SLUG (#9585), CHD1 (#4351), CHD2 (#4170), Cleaved-GSDME (55879 T) , GPX4 (59735), (Cell Signaling Technology); GSDMD (SY-R24514),

(2) Genetic loss of CHD1 regulates distinct histone post-translational modifications in the development of castration-resistant prostate cancerNeoplasiaMarch 1, 2026Tanaya A. Purohit, Joseph Gawdzik, Eric A. Armstrong, Bing Yang, Zachery Schultz, Kayla Bahr, Truman J. Do, Rehaan Machhi, Sean Sardeson, Mohammad Rizvi, et al.β-mercaptoethanol), sonicated, and heated at 90C. The protein lysates were probed with antibodies for CHD1 (CST D8C2 4351S, RRID: AB_11179073), NSD2 (Millipore MABE191; Burlington, MA, USA), H3K36me2 (CST 2901S), EZH2 (CST

(3) Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activitiesNat CommunOctober 30, 2025Yasuhiro Tsukamoto, Atsuki Kawamura, Ayhan Yurtsever, Hidefumi Suzuki, Nichole Marcela Rojas-Chaverra, Hiroki Sato, Daisuke Ino, Takehiko Ichikawa, Weilin Wei, Shojiro Haji, et al.polyclonal anti-CHD1 (Abcam, ab244391, immunofluorescence); rabbit monoclonal anti-CHD1 (Cell Signaling, 4351, immunoblotting); mouse monoclonal anti-CHD1 (Santa Cruz, sc-271626, immunofluorescence and biotinylation

(4) CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumorsNature CancerMay 13, 2025Feiyu Chen, Haoyan Li, Yin Wang, Ximing Tang, Kevin Lin, Qidong Li, Chenling Meng, Wei Shi, Javier Leo, Xin Liang, et al.our previous studies45,62. The antibodies used included anti-CHD1 (D8C2; Cell Signaling Technology, 4351; 1:1,000), anti-SREBF2 (Cayman Chemical, 10007663; 1:1,000), anti-SNF2H (D4W6N; Cell Signaling Technology,

(5) Androgens mediate sexual dimorphism in Pilarowski-Bjornsson SyndromemedRxivMay 7, 2025Kimberley Jade Anderson, Eirny Tholl Thorolfsdottir, Ilana M. Nodelman, Sara Tholl Halldorsdottir, Stefania Benonisdottir, Malak Alghamdi, Naif Almontashiri, Brenda J. Barry, Matthias Begemann, Jacquelyn F. Britton, et al.incubated overnight with primary antibodies (anti-CHD1, 1:1000 dilution, Cell Signaling Technologies, 4351; anti-beta-Actin, 1:1000 dilution, Abcam, ab8224). Membranes were washed 3X with tris-buffered saline

(6) Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscapeMolecular CellApril 18, 2024Prajwal C. Boddu, Abhishek K. Gupta, Rahul Roy, Bárbara De La Peña Avalos, Anne Olazabal-Herrero, Nils Neuenkirchen, Joshua T. Zimmer, Namrata S. Chandhok, Darren King, Yasuhito Nannya, et al.antibody,Cell signaling technology,Cat#2729 Rabbit anti-CHD1 (D8C2) antibody,Cell signaling technology,Cat#4351 Rabbit polyclonal anti-HDAC2 (D6S5P) antibody,Cell signaling technology,Cat#57156 Rabbit polyclonal

(7) CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5pTurkish Journal of BiologyFebruary 27, 2024FanYe ZENG, JunTao ZHAO, MengTing TONG, WenTing HE, Nan LI, YuXiang FAN, YanHua ZHU, LiPing ZHANG, HongLiang ZHANG5% nonfat milk powder for 1 h and reacted with primary antibodies GAPDH (2118, CST, USA) and CHD1 (4351, CST, USA) overnight at 4 °C. After TBST washing, the cells were incubated with the corresponding horseradish

(8) CHD1 deletion stabilizes HIF1α to promote angiogenesis and glycolysis in prostate cancerAsian journal of andrologyMarch 1, 2023Wang YZ, Qian YC, Yang WJ, Ye LH, Guo GD, Lv W, Huan MX, Feng XY, Wang K, Yang Z, et al.(#20368-1-AP), and PHD3 (#18325-1-AP) were purchased from Proteintech (Wuhan, China). Antibodies against CHD1 (#4351), HIF1α (#14179), von Hippel–Lindau tumor suppressor (VHL; #68547), and hydroxy-HIF1α (#3434) were purchased

(9) Gene therapy targeting miR‑212‑3p exerts therapeutic effects on MAFLD similar to those of exerciseInternational journal of molecular medicineFebruary 1, 2023Sun B, Zhang Y, Zhang M, Liu R, Yang W.follows: Anti-EGR1 (1:1,000; cat. no. 55117-1-AP, ProteinTech Group, Inc.), anti-CHD1 (1:1,000; cat. no. 4351S, Cell Signaling Technology, Inc.), anti-FGF21 (1:1,000; cat. no. ab171941, Abcam), anti-ERK1/2 (1:1,000;

(10) Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancerJCI insightDecember 8, 2021De Sarkar N, Dasgupta S, Chatterjee P, Coleman I, Ha G, Ang LS, Kohlbrenner EA, Frank SB, Nunez TA, Salipante SJ, et al.1 hour. The membranes were then probed overnight at 4°C for CHD1 (Cell Signaling Technology catalog 4351), 1:1000 dilution, and GAPDH (GeneTex catalog GTX627408), 1:5000 dilution, in PBS/0.1% Tween 20 and

(11) Chd1 protects genome integrity at promoters to sustain hypertranscription in embryonic stem cellsNature communicationsAugust 11, 2021Bulut-Karslioglu A, Jin H, Kim YK, Cho B, Guzman-Ayala M, Williamson AJK, Hejna M, Stötzel M, Whetton AD, Song JS, et al.at 4 °C or for 1 h at room temperature with the following antibodies: Chd1 (1:1000, Cell Signaling, 4351), Top2β (1:500, Santa Cruz Biotechnology, sc-13059), Atm (1:250, Genetex, GTX70103 and Abcam, ab78),

(12) Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate CancerCancer discoverySeptember 1, 2020Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, Ittmann M, Shang X, Jiang S, Li H, et al.inhibitors. Proteins were blotted following standard protocol. Antibodies specific for CHD1 (Cell Signaling, #4351S) and β-actin (Sigma, #A3854) were purchased from the indicated companies. MDSC and T Cell Migration

(13) MAP3K7 and CHD1 Are Novel Mediators of Resistance to Oncolytic Vesicular Stomatitis Virus in Prostate Cancer CellsMolecular Therapy - OncolyticsJune 26, 2020Robert S. Bayne, Shelby Puckett, Lindsey Ulkus Rodrigues, Scott D. Cramer, Jingyun Lee, Cristina M. Furdui, Jeff W. Chou, Lance D. Miller, David A. Ornelles, Douglas S. Lylesrabbit monoclonal anti-TAK1 D94D7 (#5206, Cell Signaling Technology), rabbit monoclonal anti-CHD1 D8C2 (#4351, Cell Signaling Technology), and mouse monoclonal anti-VSV M protein 23H12.67 Flow Cytometry PC3 cells

(14) Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin DysregulationCancer cellApril 13, 2020Zhang Z, Zhou C, Li X, Barnes SD, Deng S, Hoover E, Chen CC, Lee YS, Zhang Y, Wang C, et al.for western blot are (also listed in Key Resources Table):(1)CHD1 (D8C2) Rabbit mAb, Cell Signaling, Cat #4351(2)AR Antibody (N-20), Santa Cruz, sc-816(3)KLK3 (D6B1) XP® Rabbit mAb, Cell Signaling, Cat # 5365(4)PMEPA1

(15) Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 ExpressionMolecular cellJanuary 3, 2019Jin X, Ding D, Yan Y, Li H, Wang B, Ma L, Ye Z, Ma T, Wu Q, Rodrigues DN, et al.,Cell Signaling Technology,Cat# 5206S; RRID: AB_10694079 Rabbit monoclonal anti-CHD1,Cell Signaling Technology,Cat# 4351S; RRID: AB_11179073 Rabbit monoclonal anti-PARP,Cell Signaling Technology,Cat# 9532S; RRID: AB_10695538 Rabbit

(16) Role for Chromatin Remodeling Factor Chd1 in Learning and MemoryFrontiers in molecular neuroscienceJanuary 1, 2019Schoberleitner I, Mutti A, Sah A, Wille A, Gimeno-Valiente F, Piatti P, Kharitonova M, Torres L, López-Rodas G, Liu JJ, et al.performed according to the Zymo-Spin ChIP Kit protocol. The antibody used for ChIP assays was α-CHD1 (D8C2-4351, Cell Signaling Technology). To correct for potentially different amounts of input chromatin, we measured

(17) SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone SensitivityClinical Cancer ResearchNovember 15, 2018Gunther Boysen et al.(Millipore, WBLUC0500). Primary antibodies were anti-CHD1 rabbit mAb (clone D8C2, Cell Signaling Technology, 4351) and anti-GAPDH (clone 6C5, Millipore, MAB374). Secondary antibodies were anti-rabbit and anti-mouse

(18) SPOP-Mutated/CHD1-Deleted Lethal Prostate Cancer and Abiraterone SensitivityClin. Cancer Res.August 1, 2018Gunther Boysen, Daniel N. Rodrigues, Pasquale Rescigno, George Seed, David Dolling, Ruth Riisnaes, Mateus Crespo, Zafeiris Zafeiriou, Semini Sumanasuriya, Diletta Bianchini, et al.(Millipore, WBLUC0500). Primary antibodies were anti-CHD1 rabbit mAb (clone D8C2, Cell Signaling Technology, 4351) and anti-GAPDH (clone 6C5, Millipore, MAB374). Secondary antibodies were anti-rabbit and anti-mouse

(19) The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational OutputCell stem cellMarch 1, 2018Bulut-Karslioglu A, Macrae TA, Oses-Prieto JA, Covarrubias S, Percharde M, Ku G, Diaz A, McManus MT, Burlingame AL, Ramalho-Santos M.,Santa Cruz Biotechnology,"Cat# sc-292009, RRID:AB_10852342" "Anti-Chd1, rabbit monoclonal",Cell Signaling Technology,"Cat# 4351S, RRID:AB_11179073" "Anti-Tip60, rabbit",GeneTex,"Cat# GTX112197, RRID:AB_1950610" "Anti-Brd1, mouse

(20) Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancerNatureFebruary 23, 2017Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, et al.cocktails (Sigma-Aldrich). Cell lysates (500 μl) were incubated with anti-CHD1 antibody (Cell signaling #4351S) or control IgG overnight at 4°C. Magnetic or agarose beads (10μl, Novex, # 10003D) were added to each

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CHD1 (D8C2) Rabbit mAb

CHD1 (D8C2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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CHD1 (D8C2) Rabbit mAb from Cell Signaling Technology

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