HMGA2 (D1A7) Rabbit mAb 8179S from Cell Signaling Technology

Product Specs
ItemHMGA2 (D1A7) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8179S
Quantity100 µl
ApplicationsW, IHC-P, IF-IC
ReactivityH, M, R
ClonalityMonoclonal
TargetHMGA2
HostRabbit
NCBI Gene AliasesBABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9
NCBI Full Gene Namehigh mobility group AT-hook 2
Research AreaChromatin Regulation / Nuclear Function
IsotypeIgG
CloneD1A7
Molecular Weight18

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Insulin-Like Growth Factor 2 Messenger RNA-Binding Protein 1–Mediated N6-Methyladenosine Modification Stabilizes High-Mobility Group Protein A2 Messenger RNA to Promote Intrahepatic Cholangiocarcinoma ProgressionCellular and Molecular Gastroenterology and HepatologyJune 24, 2026Yu Guo, Le Zhu, Kaiheng Hu, Xiangyu Wang, Sanfeng Han, Meiping Ni, Jixuan Chen, Keyu Shen, Qimeng Chang, Chengjie Zhang, et al.Antibodies,Commercial sources,Catalog no. HMGA2,Cell Signaling Technology,8179 IGF2BP1,Abcam,ab290736/ab313422 CK19,Proteintech,10712-1-AP Ki67,Cell Signaling Technology,34330 AKT,Cell Signaling Technology

(2) Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transitionCellMay 14, 2026José Reyes, Isabella Del Priore, Andrea C. Chaikovsky, Nikhita Pasnuri, Ahmed M. Elhossiny, Jin Park, Philipp Weiler, Tobias Krause, Andrew Moorman, Catherine Snopkowski, et al.RRID:AB_300798, 1:1000), RFP (Evrogen, AB233; RRID:AB_2571743, 1:1000), HMGA2 (Cell Signaling Technology, 8179S; clone D1A7, RRID:AB_11178942, 1:500), Moesin (Proteintech, 26053-1-AP; RRID:AB_2880353, 1:100), E-cadherin

(3) LIN28A‒let-7b axis drives the aggressive and proinflammatory phenotype of rheumatoid arthritis fibroblast-like synoviocytesArthritis Research & TherapyApril 13, 2026Hee Young Chae, Kyungrim Yi, Su-Geun Lim, Ji Yeong Park, Hyejin Hyung, Si-Yong Kim, Wanil Kim, Sang-Il Lee, Dong Kyu Choi, Myoung Ok Kim, et al.4 °C with primary antibodies: anti-LIN28A (#3978, Cell Signaling Technology, MA, USA), anti-HMGA2 (#8179, Cell Signaling Technology), anti-MMP1(#m6427, Sigma-Aldrich), anti-MMP3(#sc-6839, Santa Cruz Biotechnology),

(4) Critical role for a high-plasticity cell state in lung cancerNatureJanuary 21, 2026Jason E. Chan, Chun-Hao Pan, Jonathan Rub, Gary Guzman, Klavdija Krause, Emma Brown, Zeda Zhang, Hannah Styers, Griffin Hartmann, Zhuxuan Li, et al.(R&D Systems, AF807), Flag (Sigma-Aldrich, F1804), NKX2.1 (Abcam, ab76013), HMGA2 (Cell Signaling, 8179), SPC (Sigma-Aldrich, AB3786), HOPX (Santa Cruz Biotechnology, sc-398703), Cre recombinase (Cell Signaling,

(5) High-throughput drug screening identifies EGFR/MAPK pathway targeting sensitivities in organoid models of ovarian carcinosarcomaJournal of Experimental & Clinical Cancer ResearchJanuary 6, 2026Andrew Farrell, Genevieve Dall, Cassandra J. Vandenberg, Kristy Shield-Artin, Elizabeth L. Kyran, Tim Blackmore, Ratana Lim, Rachael Taylor, Chloe Neagle, Gayanie Ratnayake, et al.AE1/3, Dako), anti-vimentin (Cell Signaling Technology #5741), anti-HMGA2 (Cell Signaling Technology #8179). H&E and IHC slides were scanned digitally at 20x magnification using the Pannoramic SCAN II (3DHISTECH

(6) An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancerNature communicationsSeptember 26, 2025Söderqvist S, Viljamaa A, Geyer N, Keller AL, Ruksha K, Strell C, Hekmati N, Niculae A, Engstrand J, Sparrelid E, et al.PBS before and after fixation and were included. Primary antibodies included HMGA2 (Cell Signaling, #8179, 1:200), AMY (Sigma-Aldrich, #A8273, 1:100), KRT19 (1:20, Progen, #61010, 1:20), GAL4 (Invitrogen, #PA5-34913,

(7) HMGA2 Overexpression in Papillary Thyroid Cancer Promotes Thyroid Cell Dedifferentiation and Invasion, and These Effects Are Counteracted by SuraminInt J Mol SciFebruary 14, 2025Cindy Van Branteghem, Nicolas Henry, Ligia Craciun, Carine MaenhautTriton X-100 5% NHS PBS for 1 h and then incubated with polyclonal rabbit antibodies against HMGA2 (#8179S, Cell Signaling Technology, 1:200), TG (A0251, Dako, 1:3000) or cytokeratin 8 (Merck, #TROMA-I, 1:500)

(8) Pancreatic cancer cells hijack tumor suppressive microRNA-26a to promote radioresistance and potentiate tumor repopulationHeliyonMay 30, 2024Ming-jie Jiang, Chen-jing Lin, Fu-rao Liu, Zhu Mei, Dian-na Gu, Ling Tianincluding anti-GAPDH (CST, 2118), anti-Phospho-Histone H2AX (Ser 139) (CST, 2577), anti-HMGA2 (CST, 8179), anti-COX-2 (CST, 12282), anti-PCNA (CST, 13110), anti-phospho-Histone H3 (CST, 53348). All antibodies

(9) A prime editor mouse to model a broad spectrum of somatic mutations in vivoNature biotechnologyMarch 1, 2024Ely ZA, Mathey-Andrews N, Naranjo S, Gould SI, Mercer KL, Newby GA, Cabana CM, Rideout WM 3rd, Jaramillo GC, Khirallah JM, et al.Millipore Sigma, Cat# AB3786; RRID:AB_91588), and anti-HMGA2 (1:1000, Cell Signaling Technologies, Cat# 8179S; RRID:AB_11178942). ImPRESS anti-Rabbit horseradish peroxidase and DAB Peroxidase Substrate Kit (Vector)

(10) Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung AdenocarcinomaCancer Research CommunicationsOctober 3, 2023Nelson F. Freeburg, Nia Peterson, Dain A. Ruiz, Amy C. Gladstein, David M. Feldsertargeting Vimentin (Abcam, ab92547, 1:1,000, RRID: AB_10562134), Hmga2 (Cell Signaling Technology, 8179S, 1:500, RRID: AB_11178942), and Epcam (Abcam, ab71916, 1:150, RRID: AB_1603782) using Citrate-based

(11) Metastatic Competency and Tumor Spheroid Formation Are Independent Cell States Governed by RB in Lung AdenocarcinomaCancer Res CommunOctober 3, 2023Nelson F. Freeburg, Nia Peterson, Dain A. Ruiz, Amy C. Gladstein, David M. Feldsertargeting Vimentin (Abcam, ab92547, 1:1,000, RRID: AB_10562134), Hmga2 (Cell Signaling Technology, 8179S, 1:500, RRID: AB_11178942), and Epcam (Abcam, ab71916, 1:150, RRID: AB_1603782) using Citrate-based

(12) Significance of High-Mobility Group A Protein 2 Expression in Pancreatic Ductal Adenocarcinoma and Ampullary AdenocarcinomaThe Turkish Journal of GastroenterologyOctober 3, 2023Damla Oflas, Funda Canaz, İlter Özer, Lütfiye Demir, Ertuğrul Çolakevaluation by covering them with a xylene-based slide sealer. HHMGA2 (dilution 1 : 400, rabbit monoclonal, 8179S, Cell Signaling, Massachusetts, USA), E-cadherin (clone NCH-38, rabbit monoclonal, Dako), and vimentin

(13) The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survivalMolecular oncologySeptember 1, 2023Shahab SW, Roggeveen CM, Sun J, Kunhiraman H, McSwain LF, Juraschka K, Kumar SA, Saulnier O, Taylor MD, Schniederjan M, et al.(D20) (#9313), histone H3 (D1H2) (#4499), phospho‐histone H3 (pHH3) (Ser10) (D7N8E) (#53348), HMGA2 (#8179), and Kras (#53270) were purchased from Cell Signaling Technology (Danvers, MA, USA). Antibodies against

(14) Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinomaBiomarker ResearchAugust 8, 2023Jiatong Wang, Chi Hin Wong, Yinxin Zhu, Xiaoqiang Yao, Kelvin K C Ng, Chengzhi Zhou, Ka Fai To, Yangchao Chenfor western blot), t-CREB (cell signaling, 9197T, 1:1000, for western blot), HMGA2 (cell signaling, 8179, 1:1000, for western blot), t-p38 (cell signaling, 8690T, 1:1000, for western blot), p-p38 (cell signaling,

(15) METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transitionJournal of molecular cell biologyAugust 3, 2023Wang Y, Chen Y, Liang J, Jiang M, Zhang T, Wan X, Wu J, Li X, Chen J, Sun J, et al.Fibronectin (AB2033, Merck Millipore), GAPDH (10494–1-AP, Proteintech), METTL3 (ab195352, Abcam), HMGA2 (8179, Cell Signaling Technology), SNAIL (ab216347, Abcam), and SLUG (ab106077, Abcam). The membranes were

(16) Unraveling the Roles of miR-204-5p and HMGA2 in Papillary Thyroid Cancer TumorigenesisInternational Journal of Molecular SciencesJune 28, 2023Cindy Van Branteghem, Alice Augenlicht, Pieter Demetter, Ligia Craciun, Carine Maenhautpolyclonal rabbit antibodies against HMGA2 (Cell Signaling Technology, (Leiden, The Netherlands, # 8179S, 1:200) or cytokeratin 8 (Merck, Hoeilaart, Belgium, #TROMA-I) in a humidified chamber at 4 °C overnight.

(17) miR-3174 Is a New Tumor Suppressor MicroRNA That Inhibits Several Tumor-Promoting Genes in GlioblastomaInternational journal of molecular sciencesMay 26, 2023Hanif F, Zhang Y, Dube C, Gibert MK Jr, Saha S, Hudson K, Marcinkiewicz P, Kefas B, Guessous F, Abounader R.Millipore Sigma, Rockville, MD, USA), CD44 (3570S, Cell Signaling Technology, Danvers, MA, USA), HMGA2 (8179S; Cell Signaling Technology), RHOA (67B9; Cell Signaling Technology, Danvers, MA, USA) CDK6 (D4S8S; Cell

(18) Anti-hsa-miR-59 alleviates premature senescence associated with Hutchinson-Gilford progeria syndrome in miceThe EMBO journalJanuary 4, 2023Hu Q, Zhang N, Sui T, Li G, Wang Z, Liu M, Zhu X, Huang B, Lu J, Li Z, et al.HMGA1 (#7777 for WB; Cell Signaling Technology, ab4078 for ChIP; and ab129153 for IHC; Abcam); HMGA2 (#8179 for WB; Cell Signaling Technology and GB111395 for IHC; Servicebio, Wuhan, China); β‐actin (A1978; Sigma,

(19) KRAS-G12D mutation drives immune suppression and the primary resistance of anti-PD-1/PD-L1 immunotherapy in non-small cell lung cancerCancer communications (London, England)September 1, 2022Liu C, Zheng S, Wang Z, Wang S, Wang X, Yang L, Xu H, Cao Z, Feng X, Xue Q, et al.Cell Signaling Technology), p70S6K (#66638‐1‐Ig; Proteintech, Rosemont, IL, USA), high mobility group protein A2 (HMGA2; #8179S; Cell Signaling Technology), chemokine (C‐X‐C motif) ligand 10 (CXCL10, #ab137018; Abcam), CXCL11 (#MAB672‐SP;

(20) Modeling diverse genetic subtypes of lung adenocarcinoma with a next-generation alveolar type 2 organoid platformGenes & developmentAugust 1, 2022Naranjo S, Cabana CM, LaFave LM, Romero R, Shanahan SL, Bhutkar A, Westcott PMK, Schenkel JM, Ghosh A, Liao LZ, et al.tissues, rabbit anti-TTF1 (1:500; Abcam ab76013) and rabbit anti-HMGA2 (1:400; Cell Signaling Technology 8179). For IHC staining of lung and organoid sections, antigen retrieval was performed in IHC retrieval solution

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HMGA2 (D1A7) Rabbit mAb

HMGA2 (D1A7) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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HMGA2 (D1A7) Rabbit mAb from Cell Signaling Technology

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