ULK1 (D8H5) Rabbit mAb 8054S from Cell Signaling Technology

Product Specs
ItemULK1 (D8H5) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number8054S
Quantity100 µl
ApplicationsW, W-S, IP
ReactivityH, M, R, Mk
ClonalityMonoclonal
TargetULK1
HostRabbit
NCBI Gene AliasesATG1, ATG1A, UNC51, Unc51.1, hATG1
NCBI Full Gene Nameunc-51 like autophagy activating kinase 1
Research AreaAutophagy
IsotypeIgG
CloneD8H5
Molecular Weight150

Questions and Answers

Can this antibody be used to study ULK1 in the context of autophagy regulation in cancer cells?

Yes, the ULK1 (D8H5) Rabbit mAb has been utilized in studies examining autophagy regulation in cancer cells. For instance, it was referenced in research demonstrating that silencing EEF2K promotes autophagic survival via activation of the AMPK-ULK1 pathway in colon cancer cells, indicating its relevance in cancer-related autophagy studies (see ).

Is this antibody effective for detecting ULK1 in Western blotting applications?

The ULK1 (D8H5) Rabbit mAb has been shown to work effectively in Western blotting applications, as evidenced by its use in multiple studies, including those investigating the role of ULK1 in autophagy and cellular metabolism (see and ).

What species can this antibody be used with for studying ULK1?

This antibody is reactive with several species, including humans, mice, rats, and non-human primates, making it versatile for comparative studies across different biological models (see product description).

Has this antibody been cited in research related to viral infections and autophagy?

Yes, the ULK1 (D8H5) Rabbit mAb has been cited in research discussing the modulation of autophagy by SARS-CoV-2, where it was used to analyze the reduction of ULK1 protein levels in infected cells, highlighting its role in viral pathogenesis and autophagy regulation (see ).

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Aspergillus fumigatus Gliotoxin Inhibits LC3-Associated Phagocytosis in Macrophages in a Calcium-Dependent MannerJ Immunol ResApril 29, 2026Yuqing Sun, Fangyan Chen, Ling Zhang, Caopei Zheng, Yu Wang, Yulin Zhang, Li HanSolarbio (Beijing, China). Antibodies: anti‐GAPDH (5174, rabbit polyclonal, 1:1000) and anti‐ULK1 (8054, rabbit monoclonal, 1:1000) were purchased from Cell Signaling Technology (Maryland, USA); anti‐LC3

(2) Ferrodoxin 1 (FDX1) drives paclitaxel resistance in ovarian cancer via copper metabolism and ULK1/ATG13-mediated autophagy: overcome by pH/ROS-responsive PPD/PDP@si-FDX1 nanomicellesJ Exp Clin Cancer ResApril 23, 2026Yangmei Gong, Zhizhi Deng, Jie Wu, Yi Huprotein lysate was used to immunoprecipitate endogenous or exogenous ULK1 with rabbit anti-ULK1 antibody (8054, 1:50, Cell Signaling, China), which was incubated overnight at 4 °C. After incubation, 20 µL of Protein A Agarose Beads

(3) Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complexPLoS PathogApril 20, 2026Stefano Sellitto, Davide Caredio, Matteo Bimbati, Giovanni Mariutti, Martina Cerisoli, Lukas Frick, Vangelis Bouris, Carlos Omar Oueslati Morales, Dalila Laura Vena, Sandesh Neupane, et al.anti-pUlk1 1:1000 (Cell Signaling Technology, 6888T), anti-Ulk1 1:1000 (Cell Signaling Technology, 8054T), anti-4EBP1 1:1000 (Cell Signaling Technology, 9452S), anti-pS6 1:1000 (Cell Signaling Technology,

(4) TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK SignalingCurr Issues Mol BiolApril 14, 2026Xiaochen Yu, Duopeng An, Dadui Ren, Peng He, Yunkai Yang, Nanye Chen, Rui Wang, Shan Wu, Jun Feng, Meiqing Feng1:1000), phospho-ULK1(S555) (Cell Signaling Technology, 5869; 1:1000), ULK1 (Cell Signaling Technology, 8054; 1:1000), GOT2 (Santa Cruz Biotechnology, sc-271702; 1:1000), GAPDH (Cell Signaling Technology, 2118;

(5) Constitutive AMPK activation prevents hepatocellular carcinoma development through inhibition of HNF4α activitySci AdvApril 10, 2026Zhen Sun, Bernard Linares, Cassidy Urdiales, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L. Van Nostrand,Cell Signaling Technology,23402 P-ULK1 (Ser555) (D1H4) Rabbit mAb,Cell Signaling Technology,5869 ULK1,Cell Signaling Technology,8054 Acetyl-CoA Carboxylase Rabbit mAb,Cell Signaling Technology,3662 Phospho-ACC (Ser79) Rabbit mAb,Cell Signaling Technology

(6) The c-Abl-RIPK3 Axis Drives Mitochondrial Dysfunction and Impaired Mitophagy in Gaucher Disease ModelsAntioxidants (Basel)April 9, 2026Cristian M. Lamaizon, Renatta Tironi-Hernández, Nohela B. Arévalo, Sebastián D. Ahumada, Daniela A. Gutiérrez, Laura Brito-Fernández, Andrea del Campo, Silvana Zanlungo, Alejandra R. Álvarez[Cell Signaling Technology, Danvers, MA, USA, #37762], anti-ULK1 antibody [Cell Signaling Technology, Danvers, MA, USA, #8054], anti-GAPDH antibody [Santa Cruz Biotechnology, Dallas, TX, USA, #sc-32233], anti-actin antibody [Santa Cruz Biotechnology

(7) Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunityScienceApril 2, 2026Zhiyuan You, Jiyeon Kim, Chuansheng Guo, Haoran Hu, Nicole M. Chapman, Xiaoxi Meng, Hao Shi, Yan Wang, Cliff Guy, Anil Kc, et al.anti-ACTB (3700), anti-OPA1 (80471), anti-DRP1 (5391), anti-MFN1 (14739), anti-MFN2 (9482), anti-ULK1 (8054), anti-ULK1-Ser555 (5869), anti-AMPK (2532), anti-AMPK-Thr172 (50081), anti-LC3B (43566) (from Cell Signaling Technology

(8) Activation of the protective arm of renin-angiotensin system enhances mitochondrial turnover improving respiration and decreasing integrated stress response in a human Complex III deficiency modelbioRxivMarch 27, 2026Lucía Fernández-del-Río, Andrea Eastes, David Rincón Fernández Rincón Fernández Pacheco, Nikole Scillitani, Jasmine Garza, Matthew Dugan, Matheus Pinto Pinto de Oliveira, Pradnya Kadam, Iman Gauhar, Karel Erion, et al.(Aviva Systems Biology, ARP53280_P050); anti-phospho ULK1 (S638) (Cell Signaling, 14205); anti-ULK1 (Cell Signaling, 8054); anti-LAMP1 (Cell Signaling, 51774); anti-MasR (Santa Cruz Biotechnology, sc-390453); anti-GST-Tag

(9) Eight-week dietary methionine restriction does not impair resistance exercise-induced mTORC1 signalling activation in ratsBiochemistry and Biophysics ReportsMarch 1, 2026Naoki Fukao, Mito Watanabe, Ryo Takagi, Koki Okumura, Naomi Yoshii, Koma Kawabata, Satoshi FujitaCST), Phospho-Akt Ser473 (#9271, CST), AMPKα (#2532, CST), Phospho-AMPKα Thr172 (#2537, CST), ULK1 (#8054, CST), Phospho-ULK1 Ser317 (#12753, CST), LC3B (#2775, CST), p62 (#PM045, Medical & Biological Laboratory,

(10) 4-Methoxydalbergione Induces Dual Activation of Apoptosis and Autophagy-Dependent Cell Death via ROS-MAPK Signaling in Human Neuroblastoma CellsCellsFebruary 28, 2026Tonking Bastola, Ren-Bo An, Chi-Su Yoon, Hyuncheol Oh, Jungwon SeomTOR (#2972), p-Raptor (#2083), Raptor (#2280), pULK1-Ser-317 (#12753), p-ULK1-Ser-757 (#6888), ULK1 (#8054), ATG5 (#2630), P62 (#5114), Beclin1 (#3738), pS6 (#2215), and S6 (#2317) were purchased from Cell Signaling Technology

(11) VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagementNature CommunicationsFebruary 21, 2026Somya Vats, Pedro Dionisio, Quentin Lemercier, Raphael Pineau, Ludivine Therreau, Joanna Lipecka, Béatrice Cholley, Jean-Baptiste Moog, Jose Wojnacki, Céline Keime, et al.ab56416, WB 1/5000), Anti pS757-ULK1 (Cell Signaling, 14202 T, WB 1/1000), Anti ULK1 (Cell Signaling, 8054, WB 1/1000), Anti pT389-P70S6K (Cell Signaling, 9208S, WB 1/1000), P70S6K (Cell Signaling, 9234, WB

(12) Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral ReplicationAdvanced ScienceFebruary 21, 2026Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Pengmonoclonal anti‐ZsGreen (Origene:TA180002; 1:2000), rabbit monoclonal anti‐ULK1 (Cell Signaling Technology: 8054T; 1:1000), rabbit monoclonal anti‐ATG13(Abcam: AB201467; 1:1000), rabbit monoclonal anti‐Beclin1(Abcam:

(13) mTOR-driven autophagy suppression defines metabolic vulnerability in CDK4/6 inhibitor-resistant HR+/HER2− breast cancerCell Death & DiseaseFebruary 19, 2026Luise von Wichert, Alina Stroh, Marie Witt, Michael Wanzel, Marco Mernberger, Sebastian Griewing, Thomas Wündisch, Berit M. Pfitzner, Julia Teply-Szymanski, Anne-Sophie Litmeyer, et al.Cell Signaling), total p70S6Kinase (H9) (1:500, sc-8418, Santa Cruz Biotechnology), ULK1 (1:1000, #8054, Cell Signaling), AMPKα (1:1000, #2603, Cell Signaling), Acetyl-CoA Carboxylase (1:1000, #3676, Cell Signaling

(14) Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesisEMBO ReportsFebruary 19, 2026Marta H Artes, Simona Iacobucci, María J Barallobre, Paula Carballeira, Marta Garcia-Cajide, Alejandro Pérez-Venteo, Natalia Padilla, Bárbara S Viegas, Aitana Díaz-Vásquez, A Silvina Nacht, et al.ab9051), H3K9me2 (Abcam, ab1220), H3K9me3 (Abcam, ab8898), NFIA (Abcam, ab 228897), ULK1 (Cell Signaling, #8054), p-ULK1 (ser 757) (Cell Signaling, #6888), alpha TUBULIN (Abcam, ab4074), p-H2A.X (Ser139) clone JBW301

(15) PDZK1‐ULK1 Axis Triggers Lipophagy to Inhibit Tumor Progression and Sunitinib Resistance in Clear Cell Renal Cell CarcinomaAdvanced ScienceFebruary 16, 2026Xuan Qi, Yu Guo, Yumeng Yang, Haibo Wang, Xiaomei Yang, Ran Song, Qiong Qin, Yan Zhang, Meihan Hu, Haixing Zhou, et al.SQSTM1 (#PTM‐6434), and Lamin B (#PTM‐6357) from PTM BIO (Hangzhou, China). MAP1LC3B (#3868), ULK1 (#8054), and LEF1 (#2230) from CST. Importin α5 (#18137) from Proteintech (Wuhan, China). 4.3 Co‐Immunoprecipitation (Co‐IP

(16) FKBP5 regulates interferon signaling leading to myeloid cell activation in multiple sclerosisJournal of NeuroinflammationFebruary 10, 2026Cinthia Gonzalez Cruz, Jessica Gibson, Maggie Kita, Narendra V. Sankpal, Ignazio S. Piras, Claudia CantoniTBST, primary antibodies FKBP5 (1:1000; Cell Signaling Technology (CST), 12210S, ULK (1:1000; CST, 8054), pULK (1:1000; CST, 5869), AKT (1:1000; CST, 9272), or LC3B (1:200; Santa Cruz Biotech, sc-376404)

(17) A novel SO2 probe inhibits lysophagy induced by Senecavirus A infection by promoting LAMP1 Cys375 sulfenylationPLoS PathogFebruary 5, 2026Shuo Wang, WenWen Han, BaoXiang Zhao, Ye Hong, Jun Li, JunYing Miao, ZhaoMin Linwas from Sigma Aldrich (St. Louis, Missouri, USA). Antibodies of LC3B (3868), STSQM1/p62 (2324), ULK1(8054T); Atg16L1(8089S) were from Cell Signaling Technology (USA).Antibodies of LAMP1(A2582);Beclin 1(A22361)

(18) Peiminine‐Induced Selective Autophagy of AIM2 Inflammasomes Rescues Cerebral Ischemic InjuryJournal of the American Heart AssociationFebruary 3, 2026Zhu‐chen Zhou, Meng‐ting Liu, Yi‐jia Fangma, Bing‐jie Wan, Jing Zhou, Xiao‐lan Zhang, Yu‐ting Yan, Shu‐hui Deng, Yan Zhang, Yuan‐jie Zhang, et al.Abclone, A24336), p‐ULK1 (p‐Unc‐51 like autophagy activating kinase 1; Affinity, AF2301), ULK (CST, 8054), Beclin (Abclone, A21191), p‐AMPK (p‐AMP‐activated protein kinase; CST, 2535), AMPK (CST, 5831), p‐Akt

(19) Ablation of Tumor-Derived IGFBP-3 Attenuates Cancer-Associated Skeletal Muscle Wasting in Murine Pancreatic CancerAmerican Journal of Physiology-Cell PhysiologyFebruary 1, 2026Zachary R. Sechrist, Daniel J. Belcher, Nidhi R. Patel, Zoe J. Pittman, Edward M. Schwarz, Calvin L. Coleanti-FoxO1 (Thermo #MA5-14846, RRID:AB_10987316); anti-pFoxO1 (CST #9461, RRID:AB_329831); anti-ULK1 (CST #8054, RRID:AB_11178668); anti-LC3b (Novus #NBP259800, RRID:AB_3094850); anti-AKT (CST #4691, RRID:AB_915783);

(20) RCC1 Domain‐Containing Protein 1 Promotes Colon Cancer Malignant Progression by Activating Autophagy‐Dependent WNT5A Secretion in Cancer‐Associated FibroblastsJournal of the Royal Society of New ZealandFebruary 1, 2026Chao Liu, Sheng Xu, Yuanyuan Liu, Yuntian Tanganti‐AMPKα (Cat# 5832, CST, 1:1000), anti‐phospho‐ULK1 (Ser757) (Cat# 14202, CST, 1:1000), anti‐ULK1 (Cat# 8054, CST, 1:1000), anti‐phospho‐CaMKII (Thr286) (Cat# 12716, CST, 1:1000), anti‐CaMKII (Cat# 4436, CST,

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ULK1 (D8H5) Rabbit mAb

ULK1 (D8H5) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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ULK1 (D8H5) Rabbit mAb from Cell Signaling Technology

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