Phospho-PERK (Thr980) (16F8) Rabbit mAb 3179L from Cell Signaling Technology

Product Specs
ItemPhospho-PERK (Thr980) (16F8) Rabbit mAb
CompanyCell Signaling Technology
Price $947.00 Inquire
Catalog Number3179L
Quantity300 µl
ApplicationsW
ReactivityM, R
TargetPERK (Thr980) phosphate mouse
ModificationsPERK (Thr982) phosphate
HostRabbit
NCBI Gene AliasesPek, Perk
ClonalityMonoclonal
NCBI Full Gene Nameeukaryotic translation initiation factor 2 alpha kinase 3
Research AreaProtein Folding and Trafficking
Clone16F8
Molecular Weight170

Questions and Answers

Can this antibody be used to study the unfolded protein response in cancer cells?

Yes, the Phospho-PERK (Thr980) Rabbit mAb has been utilized in studies investigating the unfolded protein response, particularly in the context of cancer. For instance, it was used to assess ER stress markers in breast cancer cells treated with a novel herbal extract, JI017, which induced apoptosis through the activation of the PERK pathway (see ).

What species can I use this antibody on for my experiments?

The Phospho-PERK (Thr980) Rabbit mAb is reactive with mouse and rat samples, making it suitable for studies involving these species.

Has this antibody been cited in any studies related to tuberculosis?

Yes, the antibody has been referenced in a study examining the effects of a small molecule that activates transcription factor EB, which is linked to the PERK pathway, in a mouse model of tuberculosis (see ). This highlights its relevance in research focused on host-directed therapies for infectious diseases.

What is the recommended dilution for using this antibody in Western blot applications?

The Phospho-PERK (Thr980) Rabbit mAb is typically used at a dilution of 1:1,000 in Western blot applications, as indicated in various studies that employed this antibody for detecting phosphorylated PERK levels (see , ).

Cell Signaling Technology

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Danvers, Massachusetts 01923

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Phone: 978-867-2388
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Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) RNA-binding protein ELAVL1 modulates WDR36 to inhibit p53 pathway and reduce calcium overload in retinal cells under acute pressure elevationOpen Life SciApril 20, 2026QingFeng Meng, BaoLi Ning, WenXiong Chen, JingJing Zhang, Jun FuGRP78/BiP (#3177, Cell Signaling Technology), ATF4 (#11815, Cell Signaling Technology), p-PERK (Thr980) (#3179, Cell Signaling Technology), p-IRE1α (Ser724) (ab124945, Abcam), GAPDH (#5174, Cell Signaling Technology),

(2) Sunitinib induces immunogenic cell death through eIF2α phosphorylation to potentiate immunotherapy in HCCiScienceApril 17, 2026Yimei Gu, Hanbing Mai, Peijian Huang, Hui Yuan, Mingxuan Sun, Huixin Gao, Chenyu Shang, Yangfen Ou, Jizhou Tan, Xianzhang Huang, et al.Chemicals,Cat#F0257 PERK,Selleck Chemicals,Cat# F0027 Phospho-PERK (Thr980),Cell Signaling Technology,Cat#3179; RRID:AB_2095853 Calreticulin,ImmunoWay,Cat#YT0620 HMGB1,ImmunoWay,Cat#YM8327 β-actin,ImmunoWay,Cat#YM8343 PD-L1/CD274,Proteintech,Cat#28076-1-AP;

(3) Nanoparticle-Loaded Injectable Hydrogel Alleviates Titanium Particle-Induced Osteolysis by Disrupting GATA6/DDX3X-Mediated Macrophage InflammationBiomaterials ResearchApril 16, 2026Sipeng Lin, Taihe Liu, Qi Zhu, Zhuji Ouyang, Yifan Yu, Haopeng Sun, Changchuan Li, Shixun Li, Chenhao Pan, Wing Cheuk Ko, et al.sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) process. The antibodies included p-PERK (Rabbit, 3179, Cell Signaling Technology), p-IRE1 (Rabbit, 3294, Cell Signaling Technology), β-Actin (Rabbit, 4970,

(4) Serglycin Cooperates with the Unfolded Protein Response Pathway and Inflammation to Drive Glioblastoma Cell SurvivalCellsApril 9, 2026Eleftherios N. Athanasopoulos, Chrysostomi Gialeli, Angeliki Natsiou, Dimitra Manou, Vassiliki T. Labropoulou, Achilleas D. Theocharis1:1000), PARP-1 (abcam, Cambridge, UK, ab194586, dilution 1:1000), phospho-PERK (Cell Signaling Inc., #3179, dilution 1:1000), total-PERK (Cell Signaling Inc., #3192, dilution 1:1000), phospho-p65 (Santa Cruz Biotechnology, Inc

(5) Free Fatty Acids Induce Endoplasmic Reticulum Stress-Mediated Apoptosis of Macrophages in Dairy Cows with KetosisAnimals (Basel)April 1, 2026Hongdou Jia, Xinyuan Sun, Wantong Cheng, Yue Yu, Yutong Wu, Jiayi Yan, Yunhui Fan, Qiushi Xu, Juan J. Loor, Chuang Xu, et al.Danvers, MA, USA), PERK (1:1000; 3192, Cell Signaling Technology, Danvers, MA, USA), p-PERK (1:1000; 3179, Cell Signaling Technology, Danvers, MA, USA), phosphorylated eukaryotic translation initiation factor

(6) Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathwayNeural Regeneration ResearchApril 1, 2026Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping TangCell Signaling Technology, Cat# 3192S, RRID: AB_2095847), phospho-PERK (rabbit, 1:1000, Cell Signaling Technology, Cat# 3179S, RRID: AB_2095853), eukaryotic translation initiation factor 2 subunit alpha (eIF2α; rabbit, 1:1000,

(7) Therapeutic optimization of LIPA targeting to induce endoplasmic reticulum stress and cell death in ovarian cancerOncogeneMarch 10, 2026Suryavathi Viswanadhapalli, Tae-Kyung Lee, Scott Elmore, Gaurav Sharma, Rahul Gopalam, Durga Meenakshi Panneerdoss, Xihui Liu, Karla Parra, Tanner Reese, Michael Hsieh, et al.existing cells into subgroups [20, 21]. The antibodies for p-eIF2α (#3398), eIF2α (#5324), p-PERK (#3179), PERK (#5683), CHOP (#2895), GRP78 (#3177), ATF4 (#11815), and ATF6 (#65880) were acquired from Cell Signaling Technology

(8) Interplay of Interleukin-1β and Curcumin on VEGF Expression in Breast Cancer CellsOncology ResearchFebruary 24, 2026Norbert Nass, Atanas Ignatov, Thomas KalinskiNonidet-P40 (NP-40, #1694, Applichem) [0.2%]) and sodium azide (0.03%). Primary antibodies (ERK #4695, p-ERK #3179, p38-MAPK #9212, p-p38-MAPK #4511, AKT #9272, p-AKT #4060, p65 #8242, p-p65 #3033, IκBα #4814, p-IκBα

(9) LPS–TLR4 signaling attenuates CHOP-mediated apoptosis under endoplasmic reticulum stress conditions during porcine embryonic developmentFrontiers in Cell and Developmental BiologyFebruary 24, 2026Gyu-Hyun Lee, Cheng-Lin Zhan, Song-Hee Lee, Qin-Yue Lu, Ying-Yan Jin, Ji-Yeon Lee, Kyung-Tae Shin, Xiang-Shun Cuiperformed with embryos maintained in 96-well plates. Primary antibodies such as phospho-PERK (1:100, 3179S, Cell signaling), rabbit anti- ATF4 (1:100, 10835-1-AP, Proteintech), rabbit anti-CHOP (1:100, SC-166682;

(10) Shear stress-induced Ca2+ influx triggers endoplasmic reticulum stress and cardiomyocyte apoptosis: implications for mitral regulationBiological ResearchFebruary 8, 2026Wei-Ting Chang, Jun-Ming Su, Fan-E Mo, Jhih-Yuan Shih, Wen-Tai Chiuanalyzed using antibodies against Grp78 (BD, 610978), ATF6 (Santa Cruz, sc166659), p-PERK (Cell Signaling, 3179), PERK (Cell Signaling, 3192), p-IRE1α (Abcam, ab48187), IRE1α (Abcam, ab37073), p-eIF2α (Cell Signaling,

(11) Elevated adipose inflammation, but reduced hepatic triacylglycerol storage in diet-induced obese Plin4−/− miceJournal of Biological ChemistryFebruary 1, 2026Atanaska Ivanova Doncheva, Ryoko Higa, Prabhat Khanal, Martine Villemo Øksenvåg Ingebrigtsen, Yuchuan Li, Shrikant Kolan, Pratibha Kolan, Ales Kvasnicka, Ingunn Jermstad, Shaista Khan, et al.(#3205, Cell Signaling Technology), rabbit anti-Phospho Pdha1 (#ABS-194, Milipore), rabbit anti-PERK (#3179, Cell Signaling Technology), rabbit anti-Pkm (#3106, Cell Signaling Technology), rabbit anti-Plin1 antibody

(12) Stenotrophomonas promotes gastrointestinal tumor progression via STING degradation in tumour cells and mitigated immune responseNature CommunicationsJanuary 26, 2026Huolun Feng, Kunling Chen, Zhihui Xi, Baijin Xia, Xi Chen, Yiqin Huang, Zuda Huang, Jieqing Guo, Dandan Zhu, Fa Ling, et al.50907S, Cell Signaling Technology), anti-SEL1L (cat: 29801-1-AP, Proteintech), anti-Phospho-PERK (cat: 3179 T, Cell Signaling Technology), anti-PERK (cat: 3192 T, Cell Signaling Technology), anti-cGAS (cat:79978,

(13) Basal level of ATF4 promotes T cell readiness for activation-induced proliferationiScienceJanuary 16, 2026Yushan Yi, Ce Luo, Jingyi Wang, Yujia Wang, Lixue Jin, Xiuyuan Sun, Jie Hao, Guoping Deng, Rong Jin, Qing Geantibody,Cell Signaling,Cat#94668T GCN2 antibody,Cell Signaling,Cat#3302S p-PERK antibody,Cell Signaling,Cat#3179S PERK antibody,Cell Signaling,Cat#3192T p-P70 S6K(Thr389) antibody,Cell Signaling,Cat#9234S p-P70 S6K

(14) Crocin Protects Against Retinal Ischemia–Reperfusion Injury via Regulating Sirt6-Mediated Nrf2/HO-1 Pathway in RatsInvestigative Ophthalmology & Visual ScienceJanuary 12, 2026Jing-Ni Yu, Shuang-Mei Wang, Jian-Rong Liu, Fang Xue, Xin-Guang Yang, Ze-Yi Lvanti-GAPDH (1:5000, ab8245; Abcam), anti-LaminB (1:50,000, ab16048; Abcam), and anti–phospho-PERK (1:1000, 3179; Cell Signaling Technology). Quantitative Reverse-Transcription PCR Total RNA was extracted via TRIzol

(15) Crocin Protects Against Retinal Ischemia–Reperfusion Injury via Regulating Sirt6-Mediated Nrf2/HO-1 Pathway in RatsInvestigative Ophthalmology & Visual ScienceJanuary 12, 2026Jing-Ni Yu, Shuang-Mei Wang, Jian-Rong Liu, Fang Xue, Xin-Guang Yang, Ze-Yi Lvanti-GAPDH (1:5000, ab8245; Abcam), anti-LaminB (1:50,000, ab16048; Abcam), and anti–phospho-PERK (1:1000, 3179; Cell Signaling Technology). Quantitative Reverse-Transcription PCR Total RNA was extracted via TRIzol

(16) Necrotic Cells Alter IRE1α-XBP1 Signaling and Induce Transcriptional Changes in GlioblastomaInternational Journal of Molecular SciencesJanuary 2, 2026Jiwoo Lim, Seulgi Lee, Ye-Seon Hong, Ji Ha Choi, Ala Jo, Jihee Lee Kang, Tae-Jin Song, Youn-Hee Choi(#4781), p-IκB-α (#2859), BiP (#3183), LC3B (#2775), CHOP (#2895), p62 (#88588), p-eIF2α (#9721), p-PERK (#3179), and p-PTEN (#9551) were purchased from Cell Signaling Technology (Danvers, MA, USA). Antibodies against

(17) Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stressNeural Regeneration ResearchJanuary 1, 2026Yumei Liao, Qinghua Zhang, Qiaoyun Shi, Peng Liu, Peiyun Zhong, Lingling Guo, Zijian Huang, Yinghui Peng, Wei Liu, Shiqing Zhang, et al.AB_628245), phosphorylated-PERK (p-PERK, rabbit, 1:1000, Cell Signaling Technology, Danvers, MA, USA, Cat# 3179S, RRID: AB_2095853), PERK (rabbit, 1:1000, Cell Signaling Technology, Cat# 3192S, RRID: AB_2095847),

(18) Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplayJournal of Pharmaceutical AnalysisDecember 1, 2025Ming Gu, Zhiwei Chen, Yujun Chen, Yiping Li, Hongqing Wang, Ya-ru Feng, Peiyong Zheng, Cheng Huangkinase (PERK; Cat# 20582-1-AP, Proteintech Group, Wuhan, China), phosphorylated PERK (p-PERK; Cat# 3179, Cell Signaling Technology), eukaryotic translation initiation factor 2 subunit α (eIF2α; Cat# 9722,

(19) Daytime SHP2 inhibitor dosing, when immune cell numbers are elevated, shrinks neurofibromasLife Science AllianceDecember 1, 2025Niousha Ahmari, Kwangmin Choi, Jianqiang Wu, Tilat A Rizvi, Mark Jackson, Leah J Kershner, Mi-Ok Kim, Xiyuan Zhang, Eva Dombi, Jack Shern, et al.Bio-Rad) in PBS/Tween (0.1%). Western blot analysis used antibodies from Cell Signaling pERK1/2 (Cat #3179S; 1:2,000) and total ERK1/2 (Cat #4695S; 1:2,000). Anti-pERK was detected overnight at 4°C; after washing,

(20) ER stress sensor PERK promotes T cell pathogenicity in GVHD by regulating ER-associated degradationJournal of Clinical InvestigationDecember 1, 2025Qiao Cheng, Hee-Jin Choi, Yongxia Wu, Xiaohong Yuan, Allison Pugel, Linlu Tian, Michael Hendrix, Denggang Fu, Reza Alimohammadi, Chen Liu, et al.CHOP (clone B-3) was from Santa Cruz Biotechnology. Antibodies against phosphorylated PERK (p-PERK; 3179S) and XBP1s (12782S) were from Cell Signaling Technology. Antibody against Nrf2 (ab92946) was purchased

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Phospho-PERK (Thr980) (16F8) Rabbit mAb

Phospho-PERK (Thr980) (16F8) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-PERK (Thr980) (16F8) Rabbit mAb from Cell Signaling Technology

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