BAPTA-AM, Ca2+ chelator ab120503 from Abcam

Product Specs
ItemBAPTA-AM, Ca2+ chelator
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120503
Quantity25 mg
Purity0.99
TypeChemical
Molecule NameBapta-AM

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) BH4 Oxidation‐Derived H 2 O 2 Activates ERK1 /2 Signaling via B‐Raf in Rat Dorsal Root Ganglion NeuronsJournal of NeurochemistryNovember 3, 2025Milad Mohammadi, Maike Siobal, Jörg Isensee, Philipp N. Ostermann, Tim Huchodiphenylborinate (2‐APB) (Calbiochem, cat. no. 100065), EGTA (Sigma, cat. no. E4378), BAPTA‐AM (Abcam, cat. no. ab120503), Trametinib (ApexBio, cat. no. A3018), U0126 (Calbiochem, cat. no. 662005), Lifirafenib (Chemietek,

(2) An Agonist of Zinc-Sensing G-Protein Coupled Receptor 39 Accelerates Skin Wound Healing and Protects Against UVB-Induced Keratinocyte DamageJ Exp PharmacolAugust 13, 2025Pimngeon Chatkul, Mathusorn Wongsawat, Wilasinee Satianrapapong, Apiwan Arinno, Phachara Lamlertthon, Ungkarit Wachapatthana, Tadhi Sucharitakul, Wanapas Wachiradejkul, Dollapak Sakulpanich, Bongkod Petcharat, et al.(H-89 Dihydrochloride),Medchemexpress,HY-15979A 4.,PLC inhibitor (U-73122),Sigma-Aldrich,662035 5.,Ca2+ chelator (BAPTA-AM),Abcam,Ab120503 6.,ERK inhibitor (FR180204),Tocris Bioscience,3706 7.,SIRT1 inhibitor (Sirtinol),Tocris Bioscience,3521 8.,mTOR

(3) ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repairDevelopmental CellJune 1, 2025Stefano De Tito, Eugenia Almacellas, Daniel Dai Dai Yu, Emily Millard, Wenxin Zhang, Cecilia de Heus, Christophe Queval, Javier H. Hervás, Enrica Pellegrino, Ioanna Panagi, et al.proteins" LLOMe,Cambridge Bio (BACHEM),Cat. #4000725 Xestospongin C,Tocris/Bio-techne,Cat. #1280/10U BAPTA-AM,Abcam,Cat. #ab120503 MK6-83,Tocris/Bio-techne,Cat. #5547/5547/10 ML-SA1,Tocris/Bio-techne,Cat. #4746/4746/10 LysoTracker

(4) Mycobacterium tuberculosis phagosome Ca(2+) leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophagesScience advancesMarch 28, 2025Chen D, Fearns A, Gutierrez MG.medium containing 100 nM BafA1, 1 μM Torin-1, 50 μM CQ (Sigma-Aldrich, C6628), 50 μM BAPTA-AM (Abcam, ab120503), or 50 μM EGTA-AM (Thermo Fisher Scientific, E1219). Cells were then incubated for appropriate time

(5) Protein palmitoylation is involved in regulating mouse sperm motility via the signals of calcium, protein tyrosine phosphorylation and reactive oxygen speciesBiological researchJanuary 15, 2025Xiong Y, Yi C, Zheng H, Ni Y, Xue Y, Li K.1,2-bis-(2-aminophenoxy) ethane-N, N, N’, N’-tetraacetic acid tetra(acetoxymethyl) ester (BAPTA-AM, ab120503) were procured from Abcam (Cambridge, UK). PKC inhibitor chelerythrine chloride (CC, A10196) was sourced

(6) Dissecting the Mechanical Control of Mitotic Entry Using a Cell Confinement SetupBIO-PROTOCOLJanuary 1, 2025Margarida Dantas, Débora Vareiro, Jorge G. FerreiraminAACOCF3 (TOCRIS, catalog number: 1462), used at 20 μM for 30 minBAPTA-AM (Abcam, catalog number: ab120503), used at 10 μM for 15 min2APB (Abcam, catalog number: ab120124), used at 10 μM for 30 minPara-nitro-blebbistatin

(7) T-type voltage-gated channels, Na(+)/Ca(2+)-exchanger, and calpain-2 promote photoreceptor cell death in inherited retinal degenerationCell communication and signaling : CCSFebruary 1, 2024Yan J, Wang L, Yang QL, Yang QX, He X, Dong Y, Hu Z, Seeliger MW, Jiao K, Paquet-Durand F.medium was changed every two days along with the pharmaceutical compounds including 10 µM BAPTA-AM [44] (ab120503; Abcam, Cambridge, UK), 50µM L-cis-diltiazem [45] (ab120532; Abcam), 20 µM CM4620 [46] (HY-101942; MedChemExpress,

(8) N-acetyl cysteine turns EPAC activators into potent killers of acute lymphoblastic leukemia cellsJournal of Biological ChemistryJanuary 1, 2024Nina Richartz, Wojciech Pietka, Ajay Yadav, Monica Bostad, Sampada Bhagwat, Soheil Naderi, Elin Hallan Naderi, Trond Stokke, Ellen Ruud, Heidi Kiil Blomhoff(C10444) were purchased from ThermoFisher. JC-1 (#420200) stain was purchased from Calbiochem. BAPTA-AM (#ab120503) and the EPAC1 rabbit monoclonal antibody (#ab109415) were obtained from Abcam, and the antibody was

(9) Mechanotransduction via Endothelial Adhesion Molecule CD31 Initiates Transmigration and Reveals a Role for Vascular Endothelial Growth Factor Receptor 2 in DiapedesisImmunityOctober 1, 2023Tao Fu, David P. Sullivan, Annette M. Gonzalez, Maureen E. Haynes, Prarthana J. Dalal, Nakisha S. Rutledge, Abigail L. Tierney, Julia A. Yescas, Evan W. Weber, William A. MullerHistamine dihydrochloride,Millipore Sigma,H7250-10MG Hyp9,Millipore Sigma,H9791-25MG BAPTA-AM,"Abcam, Inc.",ab120503 U-73122 hydrate,Millipore Sigma,U6756-5MG Corn oil,Millipore Sigma,C8267-500ml Tamoxifen,Millipore Sigma

(10) The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dyneinThe Journal of cell biologyMay 1, 2023Garner KEL, Salter A, Lau CK, Gurusaran M, Villemant CM, Granger EP, McNee G, Woodman PG, Davies OR, Burke BE, et al.Fibronectin (F0895; Sigma-Aldrich) and then transfected. Cells were treated with either 10 µM BAPTA-AM (ab120503; Abcam) or DMSO vehicle control for 2 h before fixation and immunofluorescence labeling. Quantification

(11) Muscarinic Receptors in Developmental Axonal Competition at the Neuromuscular JunctionMolecular NeurobiologyMarch 1, 2023Josep Tomàs, Maria A. Lanuza, Manel M. Santafé, Víctor Cilleros-Mañé, Laia Just-Borràs, Marta Balanyà-Segura, Aleksandra Polishchuk, Laura Nadal, Marta Tomàs, Neus Garciamodulators "1,2-Bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid tetrakis acetoxymethyl ester",BAPTA-AM,Ca 2+ chelator,"Ab120503, Abcam",10 mM,5 µM Substances list. Muscarinic, purinergic, TrkB, PKC, PKA substances, calcium channel

(12) Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocationThe Journal of cell biologyDecember 5, 2022Dantas M, Oliveira A, Aguiar P, Maiato H, Ferreira JG.for 30 min. To block the release of calcium ions from internal cellular stores, BAPTA-AM and 2APB (ab120503 and ab120124, respectively; Abcam) were used at 10 μM for 15–30 min. Myosin activity was perturbed using

(13) Cdk5 regulates IP3R1-mediated Ca(2+) dynamics and Ca(2+)-mediated cell proliferationCellular and molecular life sciences : CMLSAugust 24, 2022NavaneethaKrishnan S, Law V, Lee J, Rosales JL, Lee KY.USA). The Ki67 (ab92353), Prx2 (ab109367), GAPDH (6C5) and Nrf2 (ab31163) antibodies and BAPTA-AM (ab120503) were from Abcam (Cambridge, MA, USA). The protease inhibitor cocktail, ATP and XeC were from Sigma

(14) Presynaptic mechanisms underlying GABA_B-receptor-mediated inhibition of spontaneous neurotransmitter releaseCell reportsJanuary 18, 2022Alten B, Guzikowski NJ, Zurawski Z, Hamm HE, Kavalali ET.(AP-5),Sigma-Aldrich,Catalog # A8054 Picrotoxin (PTX),Sigma-Aldrich,Catalog #P1675 BAPTA-AM,Abcam,Catalog # ab120503 Saclofen,Tocris,Catalog # 0246 U73122,Tocris,Catalog # 1268 CGP-55845 hydrochloride,Tocris,Catalog

(15) Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancerNature communicationsNovember 29, 2021Munne PM, Martikainen L, Räty I, Bertula K, Nonappa, Ruuska J, Ala-Hongisto H, Peura A, Hollmann B, Euro L, et al.nM IGF-1,Sigma-Aldrich/Merck,,5 ng/ml Ryanodine,Tocris Bioscience,Ca2+ release inhibitor,100–100 mM BAPTA-Am,Abcam (ab120503),Cell permeant Ca2+ chelator,1–10 mM MK-2206,ChemieTek,AKT inhibitor,10 nM MK-0752,Selleckchem,Gamma

(16) Multistability maintains redox homeostasis in human cellsMolecular Systems BiologyOctober 6, 2021Jo‐Hsi Huang, Hannah KC Co, Yi‐Chen Lee, Chia‐Chou Wu, Sheng‐hong Chen(Cat. No. 11106) and dasatinib (Cat. No. 11498) were purchased from Cayman Chemical. BAPTA‐AM (Cat. No. ab120503) was purchased from Abcam. Fluo‐4 AM, a cell permeable Ca2+ indicator (Cat. No. F14217), was purchased

(17) Nascent RNA scaffolds contribute to chromosome territory architecture and counter chromatin compactionMolecular CellSeptember 1, 2021Kevin Michael Creamer, Heather Jill Kolpa, Jeanne Bentley LawrenceProteins" Actinomycin D,Sigma,A1410 "5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside",Sigma,D1916 BAPTA-AM,Abcam,ab120503 C0T-1 DNA (human),Roche,11581074001 "DNase I recombinant, RNase free",Roche,04716728001 Turbo™ DNase,Invitrogen,AM2238 RNase A

(18) Cold-inducible RNA-binding protein migrates from the nucleus to the cytoplasm under cold stress in normal human bronchial epithelial cells via TRPM8-mediated mechanismAnnals of translational medicineSeptember 1, 2021Mao LP, Jiao Y, Xiang JH, Luo XW, He Q, Ran DH, Xu Q, Lang CH, Chen LX.Biotech (ZB-2306, Beijing, China). TRPM8 inhibitor BCTC (ab141517), (Ca2+)i chelating agent BAPTA-AM (ab120503), and PKCα specific inhibitor safingol (ab144070) were purchased from Abcam. TRPM8-, GSK3β- and scrambled-small

(19) Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated EncephalopathiesNeuronJanuary 6, 2021Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, et al.(AP-5),Sigma-Aldrich,Catalog # A8054 Picrotoxin (PTX),Sigma-Aldrich,Catalog # P1675 BAPTA-AM,Abcam,Catalog # ab120503 Lysozyme,Sigma-Aldrich,Catalog # L6876 DNase I,Sigma-Aldrich,Catalog # D5025 TEV Protease,NEB,Catalog

(20) Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologiesJournal of Biological ChemistryJuly 1, 2020Janin Lautenschläger et al.2-deoxyglucose (Sigma-Aldrich) 0.5 m in water, menadione (Sigma-Aldrich), 1.5 mm in DMSO, BAPTA-AM (ab120503, Abcam), 2.5 mm in DMSO, BAPTA (ab144924, Abcam), 1 mm in water, CDDO-Me (Sigma-Aldrich), 1 mm in DMSO,

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BAPTA-AM, Ca2+ chelator from Abcam

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BAPTA-AM, Ca2+ chelator from Abcam

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