Add to Compare List

Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) GPR30 in spinal cholecystokinin-positive neurons modulates neuropathic paineLifeDecember 23, 2025Qing Chen, Hui Wu, Shulan Xie, Fangfang Zhu, Fang Xu, Qi Xu, Lihong Sun, Yue Yang, Linghua Xie, Jiaqian Xie, et al.voltage clamped at –70 mV. Meanwhile, the spinal slices were incubated with ACSF containing APV (100 μM, ab120003, Abcam) to block NMDA receptors and bicuculline (20 μM, ab120108, Abcam) and strychnine (0.5 μM, S450162,

(2) Cell Type-Specific Hormonal Signaling Configures Hypothalamic Circuits for ParentingbioRxivDecember 12, 2025Brandon L. Logeman, Patricia M. Horvath, Mustafa Talay, Vikrant Kapoor, Harris S. Kaplan, Catherine Dulacsupplemented with synaptic blockers (20μM Bicuculline (Tocris, Cat # 14340), 50μM AP5 (AbCam, Cat # ab120003), 10μM CNQX (Sigma, Cat # C239)) for the duration of recording. Slices were visualized on an Axio Examiner

(3) The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensingJournal of Cell ScienceOctober 1, 2025Louis John Kolling, Saptarsi Mitra, Catherine Anne Marcinkiewcz, Debra Ann Fadoolcatalog #ab120045, Abcam, Waltham, MA, USA), 25 μM (2R)-amino-5-phosphonovaleric acid (AP5, catalog #ab120003, Abcam), 1 nM margatoxin (MgTx, catalog # M8278, MilliporeSigma), 0.1 μM insulin (Fadool et al., 2011)

(4) Cell-autonomous GABAARs are essential for NMDAR-mediated synaptic transmission, LTP, and spatial memoryEMBO reportsSeptember 1, 2025Duan JJ, Jiang B, Yin W, Lin Y, Yan GM, Lu W.10437-028 Penicillin Streptomycin,GIBCO,Cat#: 15140-122 Poly-d-lysine,Sigma-Aldrich,Cat#: P6407 APV,Abcam,Cat#: ab120003 CNQX,TOCRIS,Cat#: 0190 Tetrodotoxin,BIOTIUM,Cat#: 00060 Picrotoxin,TOCRIS,Cat# 1128 d-Cycloserine,Selleck,Cat#

(5) Beta-hydroxybutyrate counteracts the deleterious effects of a saturated high-fat diet on synaptic AMPAR receptors and cognitive performanceMol MetabJuly 6, 2025Rocío Rojas, Christian Griñán-Ferré, Aida Castellanos, Ernesto Griego, Marc Martínez, Juan de Dios Navarro-López, Lydia Jiménez-Díaz, José Rodríguez-Álvarez, David Soto Del Cerro, Pablo E. Castillo, et al.action potential-dependent neurotransmitter release, 50 μM D-(−)-2-amino-5-phosphonopentanoic acid (ab120003 Abcam) to block N-methyl-d-aspartate (NMDA) receptor and 100 μM picrotoxin (P1675, Sigma) to block gamma-aminobutyric

(6) Ca(V)2.1 mediates presynaptic dysfunction induced by amyloid β oligomersCell reportsApril 22, 2025Jeans AF, Padamsey Z, Collins H, Foster W, Allison S, Dierksmeier S, Klein WL, van den Maagdenberg AMJM, Emptage NJ.,Thermo Fisher Scientific,Cat# 11668027 Aβ1-42 peptide,Abcam,Cat# ab82795 NBQX,Abcam,Cat# ab144489 D-AP5 (APV),Abcam,Cat# ab120003 ω-Agatoxin IVA,Alomone Labs,Cat# STA-500 ω-Conotoxin GVIA,Alomone Labs,Cat# C-300 Amiloride,Sigma-Aldrich,Cat#

(7) A deep learning strategy to identify cell types across species from high-density extracellular recordingsCellApril 17, 2025Maxime Beau, David J. Herzfeld, Francisco Naveros, Marie E. Hemelt, Federico D’Agostino, Marlies Oostland, Alvaro Sánchez-López, Young Yoon Chung, Michael Maibach, Stephen Kyranakis, et al.,Thermo Fisher Scientific,Cat#P36965 Gabazine,Tocris,Cat#1262 NBQX disodium,Tocris,Cat#1044 D-AP5,Abcam,Cat#ab120003 MCPG,Tocris,Cat#3696 ,, Deposited data,Deposited data,Deposited data ,, Ground-truth database (spiking

(8) Dexmedetomidine accelerates photoentrainment and affects sleep structure through the activation of SCNVIP neuronsCommunications BiologyDecember 28, 2024Ying Zhang, Wei Wang, Jiaxin Li, Dongmei Zhao, Yue Shu, Xinlu Jia, Yibo Wang, Xinqi Cheng, Liecheng Wang, Juan Cheng6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, ab120017, Abcam, UK) and 20 µM 5-phospho-D-norvaline (D-AP5, ab120003, Abcam, UK) were added to the aCSF block AMPA receptor and NMDA receptor respectively. The aCSF with10

(9) Dynamic responses of striatal cholinergic interneurons control behavioral flexibilityScience AdvancesDecember 20, 2024Zhenbo Huang, Ruifeng Chen, Matthew Ho, Xueyi Xie, Himanshu Gangal, Xuehua Wang, Jun Wangthe Care and Use of Laboratory Animals. Reagents D-(-)-2-Amino-5-phosphonopentanoic acid (catalog #ab120003 [#ab12003]) was purchased from Abcam. DNQX (6,7-dinitroquinoxaline-2,3-dione) (#0189) was purchased

(10) Enriched Environment Reduces Seizure Susceptibility via Entorhinal Cortex Circuit Augmented Adult NeurogenesisAdvanced ScienceDecember 1, 2024Zhongxia Li, Liying Chen, Fan Fei, Wenqi Wang, Lin Yang, Yu Wang, Heming Cheng, Yingwei Xu, Cenglin Xu, Shuang Wang, et al.antagonists, we used a blocker cocktail (1:1, 0.5 µL) of 10 µM CNQX (Sigma, C127) and 25 µM D‐AP5 (Abcam, ab120003) dissolved in saline. For the GABAA receptor antagonist, 5 µM bicuculline (0.5 µL) (Abcam, ab120108)

(11) Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticityMolecular BrainNovember 7, 2024Maximilian Lenz, Paul Turko, Pia Kruse, Amelie Eichler, Zhuo Angel Chen, Juri Rappsilber, Imre Vida, Andreas Vlachoscurrents (mEPSCs), the solution was substituted with TTX (0.5 µM; #ab120055, Abcam), D-AP5 (10 µM; #ab120003, Abcam) and (-)-bicuculline-methiodide (10 µM; #ab120108, Abcam). Recordings were carried out at 35°

(12) Nobiletin regulates intracellular Ca2+ levels via IP3R and ameliorates neuroinflammation in Aβ42-induced astrocytesRedox BiologyJuly 1, 2024Sanjay, Rachit Sood, Varun Jaiswal, Sung-Ung Kang, Miey Park, Hae-Jeung Leeantagonist (PPADS, ab120009), mGLUR5 antagonist (MPEP hydrochloride, ab120008), NMDAR antagonist (D-AP5, ab120003), and α7nAChR antagonist (methyllycaconitine citrate (MLA), ab120072) were purchased from Abcam (Cambridge,

(13) Scanless two-photon voltage imagingNature CommunicationsJune 14, 2024Ruth R. Sims, Imane Bendifallah, Christiane Grimm, Aysha S. Mohamed Lafirdeen, Soledad Domínguez, Chung Yuen Chan, Xiaoyu Lu, Benoît C. Forget, François St-Pierre, Eirini Papagiakoumou, et al.with ACSF as previously described. This extracellular solution was supplemented with 1 µM AP5 (Abcam, ab120003) and 1 µM NBQX (Abcam, ab120046) in all experiments except for the spontaneous activity recordings (Fig.

(14) Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neuronsNeuronApril 17, 2024Ayako Kawatake-Kuno, Haiyan Li, Hiromichi Inaba, Momoka Hikosaka, Erina Ishimori, Takatoshi Ueki, Yury Garkun, Hirofumi Morishita, Shuh Narumiya, Naoya Oishi, et al.,Cell Signaling Technology,Cat# 70024L Protein G Dynabeads,Thermo Ficher Scientific,Cat# 10004D D-AP5,Abcam,"Cat# ab120003, CAS: 79055-68-8" NBQX disodium salt,Abcam,"Cat# ab120046, CAS: 479347-86-9" Picrotoxin,Tocris,"Cat#

(15) Blue-shifted genetically encoded Ca2+ indicator with enhanced two-photon absorptionNeurophotonicsApril 4, 2024Abhi Aggarwal, Smrithi Sunil, Imane Bendifallah, Michael Moon, Mikhail Drobizhev, Landon Zarowny, Jihong Zheng, Sheng-Yi Wu, Alexander W. Lohman, Alison G. Tebo, et al.mM ascorbic acid, 25 mM D-glucose, and 1.25 mM NaH2PO4. ACSF was supplemented with 1 μM AP5 (Abcam, ab120003), 1 μM NBQX (Abcam, ab120046), and 10 μM picrotoxin (Abcam, 120315). Continuous aeration of the recording

(16) Synaptotagmin 7 transiently docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous releaseElifeMarch 27, 2024Zhenyong Wu, Grant F. Kusick, Manon M. M. Berns, Sumana Raychaudhuri, Kie Itoh, Alexander M. Walter, Edwin R. Chapman, Shigeki WatanabemM) 128 NaCl, 5 KCl, 2 CaCl2, 1 MgCl2, 30 d-glucose, and 25 HEPES, pH 7.3, with D-AP5 (50 µM) (Abcam; ab120003), CNQX (20 µM) (Abcam; ab120044), picrotoxin (100 µM) (Tocris; 1128) added to prevent recurrent excitation.

(17) Phosphorylation of pyruvate dehydrogenase inversely associates with neuronal activityNeuronMarch 20, 2024Dong Yang, Yu Wang, Tianbo Qi, Xi Zhang, Leyao Shen, Jingrui Ma, Zhengyuan Pang, Neeraj K. Lal, Daniel B. McClatchy, Saba Heydari Seradj, et al.11695067772 Dichloroacetic acid (DCA),Millipore Sigma,Cat# D54702 CNQX disodium salt,Tocris,Cat# 1045 D-AP5,Abcam,Cat# ab120003 Picrotoxin,Abcam,Cat# ab120315 Tetrodotoxin citrate (TTX),Tocris,Cat# 1069 Brain Derived Neurotrophic

(18) High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labelingeLifeFebruary 23, 2024Peibo Xu, Jian Peng, Tingli Yuan, Zhaoqin Chen, Hui He, Ziyan Wu, Ting Li, Xiaodong Li, Luyue Wang, Le Gao, et al.µM AMPA receptor antagonist CNQX (Abcam, ab120017) and 50 µM NMDA receptor antagonist D-AP5 (Abcam, ab120003) at 33 °C for 30 min. The pieces were dissociated first using the ice-cold oxygenated dissection buffer

(19) A blue-shifted genetically encoded Ca2+ indicator with enhanced two-photon absorptionbioRxivOctober 22, 2023Abhi Aggarwal, Smrithi Sunil, Imane Bendifallah, Michael Moon, Mikhail Drobizhev, Landon Zarowny, Jihong Zheng, Sheng-Yi Wu, Alexander W. Lohman, Alison G. Tebo, et al.0.3 mM ascorbic acid, 25 mM d-glucose, 1.25 mM NaH2PO4. ACSF was supplemented with 1 μM AP5 (Abcam, ab120003), 1 μM NBQX (Abcam, ab120046), and 10 μM picrotoxin (Abcam, 120315). Continuous aeration of the recording

(20) Starburst amacrine cells amplify optogenetic visual restoration through gap junctionsMolecular Therapy - Methods & Clinical DevelopmentSeptember 14, 2023Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kuriharasalt,Sigma,M4531 TPMPA,TOCRIS,1040 Bicuculline,Wako,026–16131 CGP 52432 hydrochloride,Sigma,SML0593 Mecamylamine,TOCRIS,2843/10 CNQX,Abcam,ab120044 D-AP5,Abcam,ab120003 Carbenoxolone,MERCK,C4790 Atropine,MERCK,A0132 DAPI,Life Technologies,D21490 Anti-RBPMS antibody,Abcam,ab194213 Anti-ChAT

Be the First to Write a Review!

D-AP5, NMDA glutamate site antagonist from Abcam

Description

Abcam

Citations (81)

Reviews

D-AP5, NMDA glutamate site antagonist from Abcam

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map