U0126, Selective MKK inhibitor ab120241 from Abcam

Product Specs
ItemU0126, Selective MKK inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120241
Quantity1 mg, 5 mg, 25 mg
Purity0.98
TypeInhibitor, inhibitor
Molecule Name1,4-Diamino-2,3-dicyano-1,4-bis(o-aminophenylmercapto)butadiene

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) KITENIN-CCL20 axis is a potential therapeutic target for modulating immunosuppressive tumor microenvironment in glioblastomaNeurotherapeuticsFebruary 12, 2026Eun-Jung Ahn, Sung Sun Kim, SM Abdus Salam, Eshrat Jahan, Sung-Ju Bang, Yeong Jin Kim, Sue Jee Park, Tae-Young Jung, Roo Ji Lee, Jae-Hyuk Lee, et al.FBS, and cells were serum-starved for 2 h cells were then pretreated with either ERK inhibitor (U0126, ab120241, Abcam) at concentrations of 10-20 μM for 2 h. After inhibitor pretreatment, the medium was immediately

(2) Distinct roles of HMOX1 on tumor epithelium and macrophage for regulation of immune microenvironment in ovarian cancerInternational journal of surgery (London, England)October 1, 2025Liu Y, Jiang LJ, Liu HF, Chen L, Guo L, Ge J, Zhang XY, Li J, Gong W.Servicebio. Recombinant human TGF beta 1 protein (ab50036), IMD-0354 (ab144823), LY294002 (ab120243), U0126 (ab120241), SB203580 (ab120162), PDTC (ab141406), Mouse SPP1 ELISA Kit (ab100734), Mouse TGF beta 1 ELISA Kit

(3) Angiogenic responses are enhanced by recombinant human erythropoietin in a model of periventricular white matter damage of neonatal rats through EPOR-ERK1 signalingJournal of neuropathology and experimental neurologyFebruary 21, 2024Zhu L, Yuan Q, Jing C, Sun L, Jiang L.ligation and no hypoxia exposure. Drug administration The p42/44 MAP (ERK1/2) kinase inhibitor, U0126 (ab120241, Abcam, Cambridge, United Kingdom) was dissolved in dimethyl sulfoxide (DMSO) and subsequently added

(4) miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1-containing AMPA receptors in a mouse model of Alzheimer's diseaseActa Pharmaceutica Sinica BFebruary 1, 2024Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, et al.whether ERK1/2 was involved in hyperphosphorylation of GluA1 S831, we treated N2AAPP cells with U0126 (ab120241, Abcam, 10 μmol/L), an ERK1/2 inhibitor. The results showed that U0126 treatment significantly reduced

(5) Oncostatin M promotes lipolysis in white adipocytesAdipocyteDecember 31, 2022Pim P. van Krieken, Julian Roos, Pamela Fischer-Posovszky, Stephan Wueest, Daniel Konradphosphate-buffered saline (PBS)) for the indicated durations. Tofacitinib (S5001, Selleck Chemicals), U0126 (ab120241, Abcam) and Stattic (S7024, Selleck Chemicals) were dissolved in DMSO (vehicle) and administered to

(6) Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signalingMolecular metabolismDecember 1, 2021van Krieken PP, Odermatt TS, Borsigova M, Blüher M, Wueest S, Konrad D.isoproterenol as indicated. For inhibitor experiments, cells were pre-treated for 1 h with 50 μmol/L U0126 (ab120241, Abcam, Cambridge, UK), 2 μmol/L Tofacitinib (CP-690550, LuBioScience GmbH, Zurich, Switzerland), or

(7) MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagyMolecular medicine reportsDecember 1, 2021Lan CN, Cai WJ, Shi J, Yi ZJ.received an intra-articular injection of 0.1 ml (100 µmol/l) of U0126 (an ERK inhibitor; Abcam; cat. no. ab120241), SP600125 (a JNK inhibitor; Abcam; cat. no. ab120065) or SB203580 (a p38 inhibitor; Abcam; cat. no.

(8) Cardiac macrophages prevent sudden death during heart stressNature communicationsMarch 26, 2021Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, et al.the manufacturer’s instructions. A total of 10 µmol/l AG1478 (Wako, 017-20151, Japan), UO126 (Abcam, ab120241, USA) or FR180204 (Sigma, SML0320, USA) was added 1 h before supplementation with the indicated concentrations

(9) Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathwayAutophagyMay 1, 2019Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, et al.pathway analysis, each pathway antagonist: compound C (10 μM; Abcam, ab120843) or GANT61 (20 μM; Abcam, ab120241) were given as pretreatment for 2 h every day before metformin administration. Figure 7. (Continued

(10) The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling NetworkOxidative medicine and cellular longevityJanuary 1, 2019Li X, Chen Y, Zhao J, Shi J, Wang M, Qiu S, Hu Y, Xu Y, Cui Y, Liu C, et al.alpha (phospho Y607) (Cat# ab182651), BAY117082 (Cat# ab141228), LY294002 (Cat# ab120243), U0126 (Cat# ab120241), Apoptotic DNA Ladder Detection Kit (Cat# ab66090), and Annexin V-FITC Apoptosis Staining/Detection Kit

(11) Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiencyThe Journal of endocrinologyJune 1, 2018Masarwi M, Shamir R, Phillip M, Gat-Yablonski G.mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (ERK1/2) (MEK1/2) inhibitor U0126 (cat. no. ab120241-5-B; 5 µM or 20 µM); phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (cat. no. ab120243-5-B, 5 µM or

(12) CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat ModelInternational Journal of Molecular SciencesSeptember 29, 2016Weiwei Lu, Jia Shi, Jinming Zhang, Zhengtao Lv, Fengjing Guo, Hui Huang, Wentao Zhu, Anmin Chen(ab185722, ab41037), the aggrecan neo-epitope 374ARGSV (ab3773), PNCA (ab29), SB202190 (ab120638), U-0126 (ab120241), and C59 (ab142216) were purchased from Abcam (Cambridge, UK). Antibodies for ERK (#9102), phospho-ERK

(13) KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathwayOncotargetAugust 16, 2016Yan Liu, Shu-Qing Wang, Yue-Hong Long, Su Chen, Yu-Feng Li, Jing-Hua Zhangmonoclonal anti-H3K9me2 antibody (ab1220) were obtained from Abcam. Wortmannin (ab120148) and U0126 (ab120241) were all purchased from Abcam. Plasmid construction and siRNA The coding regions of human KRAS, WSTF

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U0126, Selective MKK inhibitor from Abcam

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U0126, Selective MKK inhibitor from Abcam

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