Rapamycin, mTORC1 complex inhibitor ab120224 from Abcam

Product Specs
ItemRapamycin, mTORC1 complex inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120224
Quantity1 mg, 5 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule NameRapamycin

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(1) Hydrogen sulfide induces regulatory B cells via glycolysis and mitochondrial ROS, attenuating LPS-induced lung injuryCell Commun SignalOctober 21, 2025Yu Sun Jeong, Byunghyun Park, Mingyu Lee, Ji Cheol Kim, Ji Ye Park, Brian A. Zabel, Yoe-Sik Baetreatment, CD19+ cells were resuspended in RPMI medium at a density of 2 × 106 cells/ml. Rapamycin (5 nM; #ab120224, Abcam, Cambridge, UK), 2-DG (0.5 mM; #D8375, Sigma-Aldrich), DCA (5 mM; #347795, Sigma-Aldrich), MitoPQ

(2) Preconditioning with Rapamycin Improves Therapeutic Potential of Placenta-Derived Mesenchymal Stem Cells in Mouse Model of Hematopoietic Acute Radiation SyndromeInternational journal of molecular sciencesMay 17, 2025Slautin V, Ivanov V, Bugakov A, Chernysheva A, Gavrilov I, Maklakova I, Bazarnyi V, Grebnev D, Kovtun O.based on previous studies [40]. For preconditioning of PD-MSCs, Rapamycin (Abcam, Cambridge, UK, cat. № ab120224) was dissolved in dimethyl sulfoxide (DMSO; Abcam, Cambridge, UK, cat. № ab146591) to prepare a stock

(3) FOXO1‐NCOA4 Axis Contributes to Cisplatin‐Induced Cochlea Spiral Ganglion Neuron Ferroptosis via FerritinophagyAdvanced ScienceOctober 1, 2024Xue Wang, Lei Xu, Yu Meng, Fang Chen, Jinzhu Zhuang, Man Wang, Weibin An, Yuechen Han, Bo Chu, Renjie Chai, et al.Selleck, S5742), bafilomycin A1 (Baf, 100 nM; Abcam, ab120497), and rapamycin (RAP, 0.1 µM; Abcam, ab120224). After the culture period, the samples were collected for subsequent assays. TEM Analysis After cisplatin

(4) Role of plasmacytoid dendritic cells in vascular dysfunction in mice with renovascular hypertensionHeliyonJune 15, 2024Balaji Srinivas, Kiran Alluri, Nour-Eddine Rhaleb, Souad Belmadani, Khalid MatrouguiAlfa Aesar, Cat: J64459, Lot: Z23G009); or rapamycin (mTOR inhibitor, dose: 10 mM, 30 min, Abcam, Cat:ab120224, Lot: APN13087-1-1). After 30 min of incubation, we conducted vascular contraction to PE and relaxation

(5) Sirt6 enhances macrophage lipophagy and improves lipid metabolism disorder by regulating the Wnt1/β-catenin pathway in atherosclerosisLipids in Health and DiseaseSeptember 22, 2023Tingting Wang, Zheng Cheng, Ran Zhao, Jin Cheng, He Ren, Pengke Zhang, Pengyun Liu, Qimeng Hao, Qian Zhang, Xiaolei Yu, et al.counterstain. After treating macrophages with Ac-LDL for 30 h, they were subsequently treated with rapamycin (ab120224, Abcam) to promote autophagy or exposed to 3-MA (Sigma-Aldrich Shanghai Trading Co., Ltd.) to inhibit

(6) PRDX1 activates autophagy via the PTEN-AKT signaling pathway to protect against cisplatin-induced spiral ganglion neuron damageAutophagyDecember 1, 2021Liu W, Xu L, Wang X, Zhang D, Sun G, Wang M, Wang M, Han Y, Chai R, Wang H.for 48 h as described in the text: Baf (100 nM; Abcam, ab120497); pretreated with RAP (0.1 μM; Abcam, ab120224) or 3-MA (5 mM; Sigma-Aldrich, M9281) for 6 h; NAC (2 mM; Sigma-Aldrich, A7250); pretreated with ebselen

(7) The balance between AIM2-associated inflammation and autophagy: the role of CHMP2A in brain injury after cardiac arrestJournal of neuroinflammationNovember 5, 2021Shao R, Wang X, Xu T, Xia Y, Cui D.indicated concentrations of lipopolysaccharide (LPS) (500 ng/mL; L3127; Sigma), rapamycin (Rapa) (5 μmol/L; ab120224; Abcam), chloroquine (CQ) (10 μmol/L; C6628; Sigma), 3-methyladenine (3-MA) (10 μmol/L; M9261; Sigma),

(8) Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell LymphomaAnalytical Cellular PathologyJune 18, 2021Xintao Jia, Qiuyu He, Mei Zeng, Yuhua Chen, Yan Liucondition with stable low expression of LMP1 were cultured with the autophagy activator rapamycin (0.5 nM, ab120224, Abcam, Cambridge, UK), nuclear factor-erythroid 2-related factor 2- (Nrf-2-) specific activator cheirolin

(9) Characterization of Interplay Between Autophagy and Ferroptosis and Their Synergistical Roles on Manipulating Immunological Tumor Microenvironment in Squamous Cell CarcinomasFrontiers in immunologyJanuary 1, 2021Chen L, Niu X, Qiao X, Liu S, Ma H, Shi X, He X, Zhong M.#SH30084.03; Hyclone, South Logan, UT, USA), 100 units/mL penicillin, 100 μg/mL streptomycin. Rapamycin (#ab120224; Abcam, Cambridge, MA, USA), Erastin (#ab209693; Abcam, Cambridge, MA, USA) and Gefitinib (Iressa, AstraZeneca,

(10) TLR9 Binding to Beclin 1 and Mitochondrial SIRT3 by a Sodium-Glucose Co-Transporter 2 Inhibitor Protects the Heart from Doxorubicin ToxicityBiologyOctober 29, 2020Wang CY, Chen CC, Lin MH, Su HT, Ho MY, Yeh JK, Tsai ML, Hsieh IC, Wen MS.Louis, MO, USA. Bafilomycin A1 (88899-44-2) was from Cayman Chemical, Ann Arbor, MI, USA. Rapamycin (ab120224) was from Abcam, Cambridge, UK. The anti-LC3 antibody (ab48394, Abcam), anti-Beclin 1 (#3495, Cell Signaling,

(11) HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathwayCancer cell internationalJanuary 1, 2020Wang X, Shi B, Zhao Y, Lu Q, Fei X, Lu C, Li C, Chen H.Stuttgart, Germany). Reagents AICAR (CST, 9944) was used to activate AMPK signaling and rapamycin (Abcam, ab120224) was used to inhibit mTOR signaling in LUAD cells. LUAD cells were incubated at 37 °C for 24 h with

(12) Irbesartan Ameliorates Lipid Deposition by Enhancing Autophagy via PKC/AMPK/ULK1 Axis in Free Fatty Acid Induced HepatocytesFrontiers in physiologyJanuary 1, 2019He J, Ding J, Lai Q, Wang X, Li A, Liu S.Mito-Tempo (SML0737), and H2 O2 (323381) were purchased from Sigma-Aldrich (United States), rapamycin (ab120224) from Abcam (United States), chelerythrine chloride (CHE, HY-12048) from MedChem Express (United States),

(13) Rapamycin and FTY720 Alleviate Atherosclerosis by Cross Talk of Macrophage Polarization and AutophagyBioMed research internationalJanuary 1, 2018Sun RZ, Fan Y, Liang X, Gong TT, Wang Q, Liu H, Shan ZY, Lei L.protein analysis were removed 24 h after treatment with FTY720 (SML0700, Sigma-Aldrich) or rapamycin (ab120224, Abcam). 2.3. Immunoﬂuorescence Staining. Cells were fixed in 4% paraformaldehyde for 20 min at 4∘ C.

(14) Effects of ginkgol C17:1 on cisplatin-induced autophagy and apoptosis in HepG2 cellsOncology lettersJanuary 1, 2018Liu J, Li Y, Yang X, Dong Y, Wu J, Chen M.Beyotime Institute of Biotechnology (Haimen, China). Compound C (cat. no. ab120843), rapamycin (cat. no. ab120224), rabbit mAb SQSTM1/p62 (cat. no. ab91526) and rabbit anti-ULK1 (cat. no. ab128859) were purchased from

(15) Neurotrophin-4 induces myelin protein zero expression in cultured Schwann cells via the TrkB/PI3K/Akt/mTORC1 pathwayAnimal Cells and SystemsMarch 4, 2017Wei Guo, Yan Li, Chao Sun, Hui-Quan Duan, Shen Liu, Yun-Qiang Xu, Shi-Qing FengANA-12 (Sigma), LM11A (Sigma), PD98059 (Abcam, ab120234), LY294002 (Abcam, ab120243), rapamycin (Abcam, ab120224), and SB216763 (Sigma, S3442). Other reagents included Trizol (Invitrogen, 10296010), protease and phosphatase

(16) ASF-4-1 fibroblast-rich culture increases chemoresistance and mTOR expression of pancreatic cancer BxPC-3 cells at the invasive front in vitro, and promotes tumor growth and invasion in vivoOncology lettersApril 1, 2016Fujiwara M, Kanayama K, Hirokawa YS, Shiraishi T.Cell Signaling Technology, Inc., Danvers, MA, USA; dilution, 1:100). The mTOR inhibitor rapamycin was obtained from Abcam (#ab120224). Gemcitabine was purchased from Wako (#077-05671; Wako Pure Chemical Industries, Ltd., Osaka, Japan).

(17) Inhibition of mTOR sensitizes breast cancer stem cells to radiation-induced repression of self-renewal through the regulation of MnSOD and AktInternational Journal of Molecular MedicineFebruary 1, 2016YUANHUI LAI, XINPEI YU, XIAOHONG LIN, SHANYANG HEcriteria. The cells were exposed to ionizing radiation prior to use in the experiments. Rapamycin (ab120224; Abcam, Shanghai, China) was used to inhibit mTOR activity, and was prepared at a concentration of 20

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Rapamycin, mTORC1 complex inhibitor from Abcam

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Rapamycin, mTORC1 complex inhibitor from Abcam

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