Pifithrin-alpha-HBr, p53 Inhibitor ab120478 from Abcam

Product Specs
ItemPifithrin-alpha-HBr, p53 Inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120478
Quantity10 mg, 50 mg
Purity0.98
TypeInhibitor, Inhibitor
Molecule NamePifithrin-alpha

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Streptozotocin induces renal proximal tubular injury through p53 signaling activationScientific reportsMay 29, 2023Nakai K, Umehara M, Minamida A, Yamauchi-Sawada H, Sunahara Y, Matoba Y, Okuno-Ozeki N, Nakamura I, Nakata T, Yagi-Tomita A, et al.the same level (± insulin glargine 2–6 Units/kg). To inhibit p53 in vivo, 2.2 mg/kg of pifithrin-α (ab120478, Abcam plc., Cambridge, UK) was intraperitoneally injected just before the STZ injection as previously

(2) Transcriptional factor FoxM1-activated microRNA-335-3p maintains the self-renewal of neural stem cells by inhibiting p53 signaling pathway via Fmr1Stem Cell Research & TherapyDecember 1, 2021Jiaoying Jia, Yan Cui, Zhigang Tan, Min Liu, Yugang Jiangcombination. Meanwhile, cells were also treated with the inhibitor of p53 signaling pathway (PFT-α; ab120478; Abcam Inc., Cambridge, UK) or dimethyl sulfoxide (DMSO) as control. The oe-FoxM1 and oe-Fmr1 plasmids

(3) Downregulation of miR-128 Ameliorates Ang II-Induced Cardiac Remodeling via SIRT1/PIK3R1 Multiple TargetsOxidative Medicine and Cellular LongevityOctober 4, 2021Heqin Zhan, Feng Huang, Qian Niu, Mingli Jiao, Xumeng Han, Kaina Zhang, WenZhuo Ma, Shan Mi, Shiyu Guo, Zhenghang Zhao#C9720, Solarbio, Beijing, China), 10 μM EX527 (#ab141506, Abcam, MA, USA), and 20 μM pifithrin-a (#ab120478, Abcam, MA, USA) for 12 h in the experiments except for Western blot or 24 h in Western blot, respectively.

(4) Pharmacological inhibition of ataxia-telangiectasia mutated exacerbates acute kidney injury by activating p53 signaling in miceScientific ReportsDecember 1, 2020Masahiro Uehara et al.4, 7, and 14 days after cisplatin injection. For p53 inhibition in vivo, 2.2 mg/kg of pifithrin-α (ab120478, Abcam) was administered before cisplatin injection, and 2, 4, and 7 days after treatment. All experiments

(5) Synergistic anticancer effect of combined crocetin and cisplatin on KYSE-150 cells via p53/p21 pathwayCancer cell internationalJanuary 1, 2017Li S, Shen XY, Ouyang T, Qu Y, Luo T, Wang HQ.streptomycin were purchased from Gibco (Gibco Life Technologies, Carlsbad, CA, USA). Pifithrin-α-HBr (ab120478) (PFT-α) was supplied by Abcam (Abcam, Cambridge, UK). 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium

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Pifithrin-alpha-HBr, p53 Inhibitor from Abcam

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Pifithrin-alpha-HBr, p53 Inhibitor from Abcam

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