Leptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export ab120501 from Abcam

Product Specs
ItemLeptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120501
Quantity5 µg, 25 µg
Purity0.98
TypeInhibitor
Molecule NameLeptomycin B

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

(1) Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathwayMicrobiology SpectrumMarch 4, 2025Jakub Wadas, Haider Ali, Aleksandra Osiecka, Agnieszka Dorman, Krzysztof Pyrc, Anna Kula-PacurarReagent. After 24 h, the medium was refreshed and supplemented with leptomycin B (LMB) (20 nM, Abcam, ab120501) or an equal volume of ethanol as a negative control. Cells were placed in an incubator for 24 h and

(2) IFIT1 Exerts Opposing Regulatory Effects on the Inflammatory and Interferon Gene Programs in LPS-Activated Human MacrophagesCell reportsOctober 2, 2018John SP, Sun J, Carlson RJ, Cao B, Bradfield CJ, Song J, Smelkinson M, Fraser IDC.U937 cells were differentiated with PMA for three days. Where indicated, Leptomycin B (Abcam, cat# ab120501) was added to cells at a concentration of 1.25 ng/μl for 3h. Cells were fixed with 4% formaldehyde and

(3) Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancerCellular and Molecular BiologyApril 30, 2018Sibel í–zdaştreatment To test the effect of pharmacological inhibition of exportin-1-dependent nuclear export, LMB (Cat#ab120501; Abcam, Cambridge, MA, USA) stored as a 10.2 µM stock in ethanol was used. The cells were treated with

(4) Crm1 knockdown by specific small interfering RNA reduces cell proliferation and induces apoptosis in head and neck cancer cell linesTurkish journal of biology = Turk biyoloji dergisiJanuary 1, 2018Özdaş S, Özdaş T.were cultured at 37 °C in a humidified atmosphere of 5% CO2. 2.2. LMB treatment We used LMB (Cat# ab120501; Abcam, Cambridge, MA, USA) to test the effect of Crm1 inhibition on the apoptotic status, proliferation,

Leptomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nuclear export from Abcam