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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) GluN2A-NMDA receptor inhibition disinhibits the prefrontal cortex, reduces forced swim immobility, and impairs sensorimotor gatingActa Pharmacologica SinicaSeptember 10, 2025Yuan-ping Dong, Yun Wu, Yi-lu Zhao, Yu-min Chen, Tong-ye Liu, Yi-he Zhang, Jie-ying Xie, Jin-feng Zhang, Han Zhang, He Chen, et al.data were extracted for DEG analysis. Chemical reagents D,L-2-amino-5-phosphonovalerate (DL-APV, ab120004, Abcam, USA) and 7-chlorokynurenic acid (7-CKA, ab120024, Abcam, USA) were purchased from Abcam. Gabazine

(2) Whole-cell patch clamp and extracellular electrophysiology recordings in mouse brain slicesSTAR ProtocolsSeptember 1, 2025Huimin Chen, Xiangyi Shi, Fuzheng Guo,Hello Bio,Cat# HB1035 Ox-314,Sigma-Aldrich,Cat# 552233 Gabazine,Sigma-Aldrich,Cat# S106 DL-AP5,Abcam,Cat# ab120004 CNQX,Sigma-Aldrich,Cat# C239 Glycerol,Acros,Cat# 15892-0025 NaH2PO4·H2O,Sigma-Aldrich,Cat# 71505 NaHCO3,Sigma-Aldrich,Cat#

(3) Schizophrenia risk proteins ZNF804A and NT5C2 interact in cortical neuronsEuropean Journal of NeuroscienceApril 1, 2024Afra Aabdien, Laura Sichlinger, Zoe Borgel, Madeleine R. Jones, Iain A. Waston, Nicholas J. F. Gatford, Pooja Raval, Lloyd Tanangonan, Timothy R. Powell, Rodrigo R. R. Duarte, et al.Life Technologies, UK). After 4 days in vitro (DIV), 200 μM of d,l‐amino‐phosphonovalerate (d,l‐APV, ab120004; Abcam) was added to media to maintain neuronal health over long‐term culture and to reduce cell death

(4) Molecular Connectomics Reveals a Glucagon-Like Peptide 1 Sensitive Neural Circuit for SatietybioRxivNovember 9, 2023Addison N. Webster, Jordan J. Becker, Chia Li, Dana C. Schwalbe, Damien Kerspern, Eva O. Karolczak, Elizabeth N. Godschall, Dylan Matthew Belmont-Rausch, Tune H. Pers, Andrew Lutas, et al.(Selleckchem, S8256), KCl (Sigma Aldrich, 7447-40-7), and NBQX (Abcam, ab120046), and DL-AP5 (Abcam, ab120004) was dissolved in saline at stock concentrations and stored at −20 °C until use. Picrotoxin (Abcam,

(5) Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca(2+) homeostasis and network synchrony via PMCA2/ATP2B2NeuronFebruary 16, 2022Martín-de-Saavedra MD, Dos Santos M, Culotta L, Varea O, Spielman BP, Parnell E, Forrest MP, Gao R, Yoon S, McCoig E, et al.11668019 Poly-D-lysine,Sigma-Aldrich,Cat# P0899 B27,Life Technologies,Cat# 17504044 DL-APV,Abcam,Cat# ab120004 "cOmplete™, EDTA-free Protease inhibitor cocktail",Sigma-Aldrich,Cat# 11873580001 Phosphatase inhibitor cocktail 3

(6) Protocol for live enhanced resolution confocal imaging of dendritic spinule dynamics in primary mouse cortical neuron cultureSTAR ProtocolsJune 18, 2021Colleen R. Zaccard, David Kirchenbuechler, Sehyoun Yoon, Constadina Arvanitis, Peter Penzes,Thermo Fisher Scientific,Cat#11668019 Trypan blue,Gibco,Cat#15250-061 DL-2-Amino-5-phosphonopentanoic acid,Abcam,Cat#ab120004 Poly-D-lysine,Sigma-Aldrich,Cat#P6407-5MG Opti-MEM I Reduced Serum Media,Thermo Fisher Scientific,Cat#31985070 ,, Experimental models

(7) Rapid 3D Enhanced Resolution Microscopy Reveals Diversity in Dendritic Spinule Dynamics, Regulation, and FunctionNeuronAugust 5, 2020Zaccard CR, Shapiro L, Martin-de-Saavedra MD, Pratt C, Myczek K, Song A, Forrest MP, Penzes P.1X,GIBCO,Cat#31985070 "Trypsin, 0.25%",HyClone,Cat#SH3004201 L-amino-phosphonovalerate (APV),Abcam,Cat#ab120004 BAPTA-AM,Sigma-Aldrich,Cat#A1076 Dimethyl sulfoxide (DMSO),Sigma-Aldrich,Cat#D2650 Experimental Models:

(8) Estradiol reverses excitatory synapse loss in a cellular model of neuropsychiatric disordersTranslational psychiatryJanuary 21, 2020Erli F, Palmos AB, Raval P, Mukherjee J, Sellers KJ, Gatford NJF, Moss SJ, Brandon NJ, Penzes P, Srivastava DP.Life Technologies). Neuron cultures were maintained in presence of 200 µM D,L-amino-phosphonovalerate (D,L-APV, ab120004, Abcam) beginning on DIV (days in vitro) 4 in order to maintain neuronal health for long-term culturing

(9) Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse densityMolecular and cellular neurosciencesJuly 1, 2019Jones KA, Sumiya M, Woolfrey KM, Srivastava DP, Penzes P.Life technologies). Neuron cultures were maintained in presence of 200 μM D,L-amino-phosphonovalerate (D,L-APV, ab120004, Abcam) beginning on DIV (days in vitro) 4 in order to maintain neuronal health for long-term culturing

(10) Single-cell transcriptomic analysis of mouse neocortical developmentNature communicationsJanuary 11, 2019Loo L, Simon JM, Xing L, McCoy ES, Niehaus JK, Guo J, Anton ES, Zylka MJ.resuspended in Ca2+ and Mg2+ free HBSS with ion channel inhibitors (5 µM TTX ab120054 Abcam, 25 µM DL-AP5 ab120004 Abcam, 5 µM DNQX 2312 Tocris). Cells were kept on ice until the microﬂuidics run. A total of nine replicates

(11) Cyto-nuclear shuttling of afadin is required for rapid estradiol-mediated modifications of histone H3NeuropharmacologyDecember 1, 2018Katherine J. Sellers, Iain A. Watson, Rahel E. Gresz, Pooja Raval, Deepak P. Srivastavaactivity. Neuron cultures were maintained in presence of 200 μM d,l-amino-phosphonovalerate (D,L-APV, ab120004, Abcam) beginning on DIV (days in vitro) 4 in order to maintain neuronal health for long-term culturing

(12) Amyloid β synaptotoxicity is Wnt‐PCP dependent and blocked by fasudilAlzheimer's & DementiaMarch 1, 2018Katherine J. Sellers et al.Life technologies, UK). After 4 days in vitro (d.i.v.), 200 μM of d,l-amino-phosphonovalerate (d,l-APV, ab120004; Abcam) was added to media to maintain neuronal health over long-term culture and to reduce cell death

(13) The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand DependenteNeuroSeptember 1, 2017Acharya KD, Nettles SA, Sellers KJ, Im DD, Harling M, Pattanayak C, Vardar-Ulu D, Lichti CF, Huang S, Edwards DP, et al.Invitrogen). Neuron cultures were maintained in the presence of 200 μm d,l-amino-phosphonovalerate (d,l-APV, ab120004, Abcam) beginning on 4 d in vitro (DIV 4) to maintain neuronal health for long-term culturing and reduce

(14) Rapid modulation of synaptogenesis and spinogenesis by 17β-estradiol in primary cortical neuronsFrontiers in cellular neuroscienceJanuary 1, 2015Sellers KJ, Erli F, Raval P, Watson IA, Chen D, Srivastava DP.Life technologies). Neuron cultures were maintained in presence of 200 μM D, L-amino-phosphonovalerate (D, L-APV, ab120004, Abcam) beginning on DIV (days in vitro) 4 in order to maintain neuronal health for long-term culturing

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DL-AP5, NMDA glutamate site antagonist from Abcam

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DL-AP5, NMDA glutamate site antagonist from Abcam

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