Deferoxamine mesylate, Iron chelator ab120727 from Abcam

Product Specs
ItemDeferoxamine mesylate, Iron chelator
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120727
Quantity1 g
TypeChemical
Molecule NameDeferoxamine mesylate

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Tumors hijack macrophages for iron supply to promote bone metastasis and anemiaCellOctober 30, 2025Yujiao Han, Hirak Sarkar, Zhan Xu, Sereno Lopez-Darwin, Yong Wei, Xiang Hang, Fengshuo Liu, Kimberley Tran, Wei Wang, Jennifer M. Miller, et al.The co-cultured cells were treated with 1.5 μM of iron chelator Deferoxamine mesylate (DFO, Abcam, #ab120727), ferroportin (FPN) inhibitor VIT-2763/Vamifeport (Vam, MedChemExpress, #HY-112220) at indicated concentration,

(2) Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophyJournal of Clinical InvestigationSeptember 2, 2025Kodai Nakamura, Huascar Pedro Ortuste Quiroga, Naoki Horii, Shin Fujimaki, Toshiro Moroishi, Keiichi I. Nakayama, Shinjiro Hino, Yoshihiko Saito, Ichizo Nishino, Yusuke Ononumber of myotubes containing more than 4 filopodia to the total number of MyHC+DAPI+ nuclei; DFO (ab120727, Abcam) and FAS (091-00855, FUJIFILM) were used as an iron chelator and iron donor, respectively. For

(3) Targeting hypoxia-inducible factor-1 in a hypoxidative stress model protects retinal pigment epithelium cells from cell death and metabolic dysregulationCell death discoveryAugust 14, 2025Schubert A, Lobo Barbosa da Silva ME, Ambrock T, Terosian O, Malyshkina A, Padberg C, Larafa S, Matschke J, Fandrey J, Henning Y.inhibitors were used: Ferrostatin-1 (Fer-1; ab146169, Abcam, Cambridge, UK), Deferoxamine Mesylate (ab120727, Abcam), 2’2-Bipyridyl (D216305-2, Sigma Aldrich), Vorinostat/SAHA (S1047, Selleck Chemicals GmbH, Cologne,

(4) Superoxide Activates Ferroptosis via the Haber‐Weiss Reaction and Enhances Age‐Related Macular DegenerationAging CellAugust 10, 2025Ying Huang, Zhenxing Zhou, Mengjia Huan, Qi Guo, Xiaoqian Zhang, Ruiqi Lu, Lushu Chen, Xiumiao Li, Jin Yao, Qin Jiang, et al.inhibitors based on our previous investigation (Xu et al. 2023), including 50 μM deferoxamine mesylate (DFO, ab120727, Abcam), 10 mM ferrostatin‐1 (Fer‐1, ab146169, Abcam), 20 mM necrostatin‐1 (Nec‐1, ab141053, Abcam),

(5) Iron supplementation alleviates pathologies in a mouse model of facioscapulohumeral muscular dystrophyJ Clin InvestJuly 1, 2025Kodai Nakamura, Huascar Pedro Ortuste Quiroga, Naoki Horii, Shin Fujimaki, Toshiro Moroishi, Keiichi I. Nakayama, Shinjiro Hino, Yoshihiko Saito, Ichizo Nishino, Yusuke Ononumber of myotubes containing more than 4 filopodia to the total number of MyHC+DAPI+ nuclei; DFO (ab120727, Abcam) and FAS (091-00855, FUJIFILM) were used as an iron chelator and iron donor, respectively. For

(6) High taurocholic acid concentration induces ferroptosis by downregulating FTH1 expression in intrahepatic cholestasis of pregnancyBMC Pregnancy ChildbirthJanuary 9, 2025Wei-Jian Zeng, Hua-Jing Yang, Ying-Jie Gu, Meng-Nan Yang, Meng-Ru Sun, Sheng-Kai Cheng, Yan-Yan Hou, Wei GuFTH1-overexpressed vectors are outlined in supplementary file 3. Herein, 10 µM of deferoxamine (DFO, Abcam, Cat #: ab120727), the ferroptosis inhibitor, was utilized for 24 h. TCA-induced cell co-treatment with DFO was also

(7) Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron EffluxMolecular & Cellular ProteomicsJanuary 1, 2024Rui Che, Qingsong Wang, Minzhe Li, Jian Shen, Jianguo Jistimulated and activated with 2 μg/ml PHA (11249738001; Roche). Cells were treated with deferoxamine (DFO) (ab120727; Abcam), ferric citrate (FC) (F3388; Sigma–Aldrich), low-density lipoprotein-cholesterol (LDL-C) (H7960;

(8) Pharmacological inhibition of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) induces ferroptosis in vascular smooth muscle cellsCell Death DiscovDecember 15, 2023Binjie Yan, Darrell Belke, Yu Gui, Yong-Xiang Chen, Zhi-Sheng Jiang, Xi-Long Zheng33342 (#H3570) were purchased from Thermo Fisher Scientific (Ottawa, ON, Canada). Deferoxamine (DFO; #ab120727) and MI-2 (#ab145047) were obtained from Abcam (Cambridge, MA). Ferrostatin-1 (Fer-1; #A13247), Necrostatin-1

(9) Hypoxia aggravates ferroptosis in RPE cells by promoting the Fenton reactionCell death & diseaseJuly 29, 2022Henning Y, Blind US, Larafa S, Matschke J, Fandrey J.(Fer-1; ab146169, Abcam), Liproxstatin-1 (Lip-1; Cay-17730, Cayman Chemical), Deferoxamine Mesylate (ab120727, Abcam), 2’2-Bipyridyl (D216305-2, Sigma Aldrich), and DharmaFECT 4 Transfection Reagent (T-2004-02,

(10) PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cellsJournal of experimental & clinical cancer research : CRNovember 8, 2021You JH, Lee J, Roh JL.calcein acetoxymethyl ester (354,217; Corning Inc., Corning, NY, USA) and iron chelator, deferoxamine (ab120727; Abcam, Cambridge, UK). The cells were loaded with calcein-AM (8 μg/ml) for 30 min at 37 °C and then

(11) xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinomaOncology lettersSeptember 1, 2020Sugiyama A, Ohta T, Obata M, Takahashi K, Seino M, Nagase S.in DMSO and from Sigma-Aldrich; Merck KGaA). A total of 10 mM deferoxamine mesylate (DFO) (cat. no. ab120727; Abcam) was dissolved in water and 10 mM Z-VAD-FMK (Peptide Institute, Inc.) in DMSO. Cytotoxicity

(12) Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicityJCI insightMay 7, 2020Tadokoro T, Ikeda M, Ide T, Deguchi H, Ikeda S, Okabe K, Ishikita A, Matsushima S, Koumura T, Yamada KI, et al.Institute. Rotenone (R0090) and NAC (A0905) were purchased from Tokyo Chemical Industry. DFO mesylate (ab120727) and DXZ hydrochloride (ab141109) were purchased from Abcam. MFG (M489) was purchased from Dojindo. Echocardiography.

(13) Chronic diazepam administration increases the expression of Lcn2 in the CNSPharmacology Research & PerspectivesFebruary 1, 2017Tomonori Furukawa, Shuji Shimoyama, Yasuo Miki, Yoshikazu Nikaido, Kohei Koga, Kazuhiko Nakamura, Koichi Wakabayashi, Shinya Uenointralipid (20% i.v. fat emulsion). Deferoxamine mesylate (DFO), iron chelator, was purchased from Abcam (ab120727; Cambridge, UK), and was dissolved in saline. Chronic treatment of DZP and DFO To study the effect

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Deferoxamine mesylate, Iron chelator from Abcam

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Deferoxamine mesylate, Iron chelator from Abcam

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