Thapsigargin, Ca2+-ATPase inhibitor ab120286 from Abcam

Product Specs
ItemThapsigargin, Ca2+-ATPase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120286
Quantity1 mg
Purity0.98
TypeInhibitor, inhibitor
Molecule NameThapsigargin

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Website: http://www.abcam.com

(1) DNA damage burden causes selective CUX2 neuron loss in neuroinflammationNatureApril 1, 2026Laura Morcom, Wenlong Xia, Zhaoyang Xu, Yashika Awasthi, Celine Geywitz, Matthew O. Ellis, Tomas Noli, Amel Zulji, Daniel Yamamoto, Gemma C. Girdler, et al.Sigma-Aldrich, C2538, 41575-94-4; 6-thioguanine, Sigma-Aldrich, A4882, 154-42-7; thapsigargin, Abcam, AB120286, 67526-95-8; topotecan, Apex Bio, B2296, 119413-54-6; colchicine, Sigma-Aldrich, C975, 64-86-8; etoposide,

(2) Resting Ca2+ fluxes protect cells from fast mitochondrial fragmentation, cell stress responses, and immediate transcriptional reprogrammingCell Mol Life SciJune 14, 2025Caroline Fecher, Annemarie Sodmann, Felicitas Schlott, Juliane Jaepel, Franziska Schmitt, Isabella Lengfelder, Thorsten Bischler, Bernhard Nieswandt, Konstanze F. Winklhofer, Robert Blumcyanide-p-trifluoromethoxyphenylhydrazone)/DMSO (Sigma-Aldrich, #C2920); 25 mM SKF-96365/PBS (Abcam, #ab120280); 3 mM thapsigargin/DMSO (Abcam, #ab120286); 5 mg/ml tunicamycin/DMSO (Cell signaling, #12819). Mouse cortical glial cells Cortical glial cells

(3) Clearance of protein aggregates during cell divisionElifeJune 6, 2025Shoukang Du, Yuhan Wang, Bowen Chen, Shuangshuang Xie, Kuan Yoow Chan, David C Hay, Ting Gang Chewpre-warmed fresh medium. Drug treatments The following drugs were used in this study: Thapsigargin (Abcam, ab120286), Tunicamycin (GlpBio, GC16738), MG132 (CSN Pharm, CSN11436), YUM70 (Aladdin, Y413413), VER-155008 (CSN

(4) Clearance of protein aggregates during cell divisionElifeJune 6, 2025Shoukang Du, Yuhan Wang, Bowen Chen, Shuangshuang Xie, Kuan Yoow Chan, David C Hay, Ting Gang Chewpre-warmed fresh medium. Drug treatments The following drugs were used in this study: Thapsigargin (Abcam, ab120286), Tunicamycin (GlpBio, GC16738), MG132 (CSN Pharm, CSN11436), YUM70 (Aladdin, Y413413), VER-155008 (CSN

(5) IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cellsThoracic CancerOctober 1, 2024Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu(Cambridge, MA, USA). 4‐Phenylbutyric acid (4‐PBA, P21005) was purchased from Sigma. Thapsigargin (TG, ab120286) from Abcam. Cisplatin solution (H20040813) was purchased from HANSOH PHARMA (Jiangsu, China). Doxorubicin Hydrochloride

(6) ER-phagy restrains inflammatory responses through its receptor UBAC2The EMBO JournalSeptember 16, 2024Xing He, Haowei He, Zitong Hou, Zheyu Wang, Qinglin Shi, Tao Zhou, Yaoxing Wu, Yunfei Qin, Jun Wang, Zhe Cai, et al.and Bafilomycin A1 (cat. 19-148) were purchased from Sigma-Aldrich. CPA (cat. ab120398) and TG (cat. ab120286) were from Abcam. Carfilzomib (cat. HY-10455), tunicamycin (cat. HY-A0098) and PEP005 (cat. HY-B0719)

(7) Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanismsElifeSeptember 11, 2024Reham Abdelaziz, Adam P Tomczak, Andreas Neef, Luis A Pardoanti-Kv10.1,1:1500 Recombinant DNA reagent,pSGEM Kv10.1,Addgene #85704,, "Chemical compound, drug",Thapsigargin,Abcam,ab120286,5 µM "Chemical compound, drug",Ionomycin,Abcam,ab120116,5 µM "Chemical compound, drug",Astemizole,Esteve

(8) Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanismseLifeSeptember 11, 2024Reham Abdelaziz, Adam P Tomczak, Andreas Neef, Luis A Pardoanti-Kv10.1,1:1500 Recombinant DNA reagent,pSGEM Kv10.1,Addgene #85704,, "Chemical compound, drug",Thapsigargin,Abcam,ab120286,5 µM "Chemical compound, drug",Ionomycin,Abcam,ab120116,5 µM "Chemical compound, drug",Astemizole,Esteve

(9) Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sitesThe Journal of cell biologyApril 3, 2023Du Y, Chang W, Gao L, Deng L, Ji WK.antibody,Proteintech,11242-1-AP β-Tubulin mAB(3G6),Abbkine,A01030 TMEM55B Polyclonal antibody,Proteintech,23992-1-AP Thapsigargin,Abcam,ab120286 Lysotracker deep red,Thermo Fisher Scientific,L12492 Bafilomycin A1,MCE,HY-100558 Rapamycin,MCE,HY-10219 siRNA,siRNA,siRNA siRNA

(10) Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosisNature communicationsJuly 25, 2022Bae E, Huang P, Müller-Greven G, Hambardzumyan D, Sloan AE, Nowacki AS, Marko N, Carlin CR, Gladson CL.(PHG0311) from Life technologies; EGTA (E-4378) and EIPA (A3085) from Sigma Aldrich; and thapsigargin (ab120286) from Abcam. Processing reagents and antibodies used for immunofluorescence analysis were purchased

(11) Protein C receptor maintains cancer stem cell properties via activating lipid synthesis in nasopharyngeal carcinomaSignal transduction and targeted therapyFebruary 16, 2022Zhang P, He Q, Wang Y, Zhou G, Chen Y, Tang L, Zhang Y, Hong X, Mao Y, He Q, et al.(Pyrrolidinedithiocarbamate ammonium, 10 μM, S3633, Selleck), Ca2+-ATPase inhibitor (Thapsigargin, 1 μM, ab120286, Abcam), FASN inhibitor (C75, 50 μM, S8915, Selleck), PTGS1 and PTGS2 inhibitor (Ketoprofen, 50 μM,

(12) Ryanodine receptor RyR1-mediated elevation of Ca(2+) concentration is required for the late stage of myogenic differentiation and fusionJournal of animal science and biotechnologyFebruary 11, 2022Qiu K, Wang Y, Xu D, He L, Zhang X, Yan E, Wang L, Yin J.inhibitor of RyR1, was added as a final concentration of 10 μmol/L in culture media. Thapsigargin (THA, ab120286, Abcam, Cambridge, UK), an ER stress-inducing agent, was used at a final concentration of 100 nmol/L

(13) RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microgliaCellular signallingJuly 1, 2021Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB.T4648), Cyclosporin A (FagronLab: 803651), YM-58483 (Tocris Bioscience: 3939), and Thapsigargin (Abcam: ab120286). 5.2. Cell Culture BV2, N9, and RAW264.7 cell lines and isolated mouse peritoneal macrophages were

(14) A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitorsPLoS biologyMay 1, 2021Corman A, Kanellis DC, Michalska P, Häggblad M, Lafarga V, Bartek J, Carreras-Puigvert J, Fernandez-Capetillo O.GSK2606414 (PERKi, 516535) from Merck Millipore; Tunicamycin (11445) from Bionordika (Sweden); Thapsigargin (ab120286) from Abcam; PF-543 hydrochloride (5754) from R&D Systems (United Kingdom); ABC294640 (10587) from Cayman Chemical

(15) Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammationNature communicationsFebruary 10, 2021Ye Z, Shen Y, Jin K, Qiu J, Hu B, Jadhav RR, Sheth K, Weyand CM, Goronzy JJ.fluorescence-activated cell sorting routinely exceeded 95%. Reagents and antibodies AA (ab120916), thapsigargin (ab120286), ORAI3 Ab (ab115558), and NUR77 Ab (ab109180) were purchased from Abcam. Abs recognizing p-CAMKII (Thr286,

(16) Identification of repurposable cytoprotective drugs in vanishing white matter disease patient-derived cellsTranslational Medicine CommunicationsDecember 1, 2020Neville Ng et al.SigmaAldrich, 16911), MG132 (0–20 μM; Focus Bioscience, HY-13259) or thapsigargin (0–20 μM; Abcam, Australia, ab120286) overnight. Viability was assessed via resazurin reduction assay (STEMCELL Technologies, 75005), in which

(17) Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damageStem cell research & therapyOctober 15, 2020Fan C, Feng J, Tang C, Zhang Z, Feng Y, Duan W, Zhai M, Yan Z, Zhu L, Feng L, et al.dimethyl sulfoxide (DMSO, D8418) were purchased from Sigma-Aldrich (St. Louis, MO, USA); thapsigargin (TG, > 98% purity, ab120286) was from Abcam (Cambridge, MA, USA); compound C dihydrochloride (CpC, T6146) and acadesine (AICAR,

(18) Induction of the Unfolded Protein Response during Bovine Alphaherpesvirus 1 InfectionVirusesSeptember 2, 2020Wang S, Ma X, Wang H, He H.(3294S) were purchased from Cell Signaling Technology (Danvers, MA, USA). Thapsigargin (Tg) (Abcam, ab120286), GSK2606414 (HY-18072) (MedChem Express, Monmouth Junction, NJ, USA), APY29 (HY-17537) (MedChem Express,

(19) Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced DamageCellMay 14, 2020Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, et al.hexahydrate,Sigma-Aldrich,Cat# 203289-5G Dimethyl sulfoxide,Sigma-Aldrich,Cat# 472301 Thapsigargin,Abcam,Cat# ab120286 Cal-590 AM calcium dye,AAT Bioquest,Cat# 20510 FLIPPER-TR,Spirochrome,Cat# SC020 Critical Commercial

(20) Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapyNature communicationsMarch 11, 2020Mahameed M, Boukeileh S, Obiedat A, Darawshi O, Dipta P, Rimon A, McLennan G, Fassler R, Reichmann D, Karni R, et al.

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Thapsigargin, Ca2+-ATPase inhibitor from Abcam

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Thapsigargin, Ca2+-ATPase inhibitor from Abcam

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