PD 98059, MEK1 inhibitor ab120234 from Abcam

Product Specs
ItemPD 98059, MEK1 inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120234
Quantity1 mg, 10 mg, 50 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule Name2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

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Abcam

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Cambridge CB2 0AX

United Kingdom

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+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) ERK/mTOR signaling may underlying the antidepressant actions of rapastinel in miceTranslational psychiatryDecember 22, 2022Shen M, Lv D, Liu X, Wang C.and 10 mg/kg, i.v., Tocris Bioscience, Cat# 3406) and PD98059 (5 nmol/mice, i.c.v., Abcam, USA, Cat#ab120234). The doses of rapastinel were based on previously reported clinical and preclinical studies [13, 14]

(2) Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3Journal of neuroinflammationJuly 5, 2021Li HN, Yang QQ, Wang WT, Tian X, Feng F, Zhang ST, Xia YT, Wang JX, Zou YW, Wang JY, et al.0.9% saline. Inhibitors of JAK2 (AG490, 10 μg/μl; Abcam, #ab120950), ERK (PD98059, 5.0 μg/μl; Abcam, #ab120234), p38 MAPK (SB203580, 20 μg/μl; Abcam, #ab120162), and NF-κB (PDTC, 200 ng/μl; Sigma, #P8765) were first

(3) Expression and secretion of apoE isoforms in astrocytes and microglia during inflammationGliaJune 1, 2021Maria Fe Lanfranco, Jordy Sepulveda, Gregory Kopetsky, G. William Rebeckng/mL, the JNK inhibitor SP600125 (Cat. No. ab120065) at 10 μM, the MEK1 inhibitor PD989059 (Cat. No. ab120234) at 50 μM, the p38 MAPK inhibitor, doramapimod (BIRD, Cat. No. ab142166) at 1 μM, the IkappaB kinase

(4) Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease CardiomyopathyFrontiers in immunologyJanuary 1, 2021Nunes JPS, Andrieux P, Brochet P, Almeida RR, Kitano E, Honda AK, Iwai LK, Andrade-Silva D, Goudenège D, Alcântara Silva KD, et al.NOS2 inhibitor 1400W (W4262) were purchased from Sigma-Aldrich. Inhibitors of MEK1 and MEK2 PD98059 (ab120234), JNK SP600125 (ab120065) and MAPK SB202190 (ab120638) were purchased from Abcam. Reagents were dissolved

(5) TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathwaysInternational Journal of Molecular MedicineNovember 3, 2020Jing Zhang, Na Jiang, Jian Ping, Lieming Xuaccording to the design of the experiments. JS1 cells were pre-treated with 10 µM PD98059 (cat. no. ab120234; Abcam), 10 µM SB203580 (cat. no. ab120162; Abcam) or 10 µM SP600125 (cat. no. ab120065; Abcam) for

(6) A critical role of E2F transcription factor 2 in proinflammatory cytokines-dependent proliferation and invasiveness of fibroblast-like synoviocytes in rheumatoid ArthritisScientific ReportsDecember 1, 2018Rui Zhang, Lin Wang, Ji-hong Pan, Jinxiang HanAbcam, ab141406), PD98059 (an inhibitor of extracellular regulated protein kinases (ERK-1/2), Abcam, ab120234), or Static (an inhibitor of signal transducers and activators of transcription (STAT3), Abcam, ab120952),

(7) M-Calpain Activation Facilitates Seizure Induced KCC2 Down RegulationFrontiers in molecular neuroscienceJanuary 1, 2018Wan L, Ren L, Chen L, Wang G, Liu X, Wang BH, Wang Y.

(8) Proprotein convertase subtilisin/kexin type 6 promotes in vitro proliferation, migration and inflammatory cytokine secretion of synovial fibroblast‑like cells from rheumatoid arthritis via nuclear‑κB, signal transducer and activator of transcription 3 and extracellular signal regulated 1/2 pathwaysMolecular medicine reportsDecember 1, 2017Jiang H, Wang L, Wang F, Pan J.ab141406; Abcam), the STAT inhibitor stattic (cat. no. ab120952 Abcam), or the ERK‑1/2 inhibitor PD98059 (cat. no. ab120234, Abcam) was added to cells in the presence of 150 ng/ml rhPCSK6 for 2 h. RASF cells were then analyzed

(9) p38 MAPK‑MK2 pathway regulates the heat‑stress‑induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cellsOncology LettersNovember 8, 2017Hongbo Li, Yanan Liu, Zhengtao Gu, Li Li, Yunsong Liu, Lin Wang, Lei SuµM; cat. no. ab120065; Abcam), SB203580 (5 µM; cat. no. ab120162; Abcam), PD98059 (10 µM; cat. no. ab120234; Abcam), SB202474 (10 µM; cat. no. IMA1013; Jingke Science and Technology Co., Ltd., Shanghai, China),

(10) Neurotrophin-4 induces myelin protein zero expression in cultured Schwann cells via the TrkB/PI3K/Akt/mTORC1 pathwayAnimal Cells and SystemsMarch 4, 2017Wei Guo, Yan Li, Chao Sun, Hui-Quan Duan, Shen Liu, Yun-Qiang Xu, Shi-Qing Fengrecombinant human neurotrophin 4 protein (Abcam, ab200241), ANA-12 (Sigma), LM11A (Sigma), PD98059 (Abcam, ab120234), LY294002 (Abcam, ab120243), rapamycin (Abcam, ab120224), and SB216763 (Sigma, S3442). Other reagents

(11) Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-Terminal Kinase (JNK) pathway in C2C12 cellsBiochemical and Biophysical Research CommunicationsDecember 24, 2015Hana Park, Nam Ho Jeoung

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PD 98059, MEK1 inhibitor from Abcam

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PD 98059, MEK1 inhibitor from Abcam

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