Etoposide, Topoisomerase II inhibitor ab120227 from Abcam

Product Specs
ItemEtoposide, Topoisomerase II inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120227
Quantity25 mg, 100 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule NameEtoposide

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Visualization, Data Extraction, and Multiparametric Analysis of 3D Pancreatic and Colorectal Cancer Cell Lines for High-Throughput ScreeningBiomedicinesJanuary 6, 2026Mikhail A. Trofimov, Ilya P. Bulatov, Velemir S. Lavrinenko, Vladimir E. Popov, Varvara S. Petrova, Anton S. Bukatin, Stanislav F. Tyazhelnikovexception of 5-fluorouracil (5-FU) (Sigma-Aldrich, F6627, St. Louis, MO, USA) and etoposide (Abcam, ab120227, Waltham, MA, USA). All compounds were stored as 10 mM stock in DMSO before use. On the third day of

(2) A simple method to efficiently generate structural variation in plantsPLoS GenetDecember 18, 2025Lindsey L. Bechen, Naiyara Ahsan, Alefiyah Bahrainwala, Mary Gehring, Prasad R. V. SatyakiProgeny of these plants were screened for phenotypes of interest (Figs 1B–F, S1). Etoposide (Abcam AB120227) stock was created by dissolving etoposide salt in DMSO to obtain a 100 mM solution. This stock was

(3) Three-Dimensional Tumor Spheroids of Pancreatic and Colorectal Cancer Cell Lines for High-Throughput Screening of Drug CandidatesACS OmegaNovember 27, 2025Mikhail Trofimov, Ilya Bulatov, Ilona Donskaia, Alexander Efremov, Ekaterina Litau, Velemir Lavrinenko, Vladimir Popov, Varvara Petrova, Anton Bukatin, Stanislav TyazhelnikovJSC BIOCAD laboratory, except for 5-fluorouracil (5-FU) (Sigma-Aldrich, F6627) and etoposide (Abcam, ab120227). All compounds were stored as 10 mM stock in DMSO before usage. For broadband screening and selecting

(4) Pooled CRISPR screens identifies key regulators of bovine stem cell expansion for cultured meatCommun BiolAugust 30, 2025Amit Zirman, Mamoun Abed El-Nabi, Ella Samuel, Leon Anavy, Zohar Yakhini, Iftach Nachman, Roni RakBriefly, cells were seeded at a density of 1 × 10⁴ cells/cm². After 24 h, 20 µM etoposide (Abcam, AB-ab120227-25-B) was added to the relevant treatment groups. Cells were subsequently washed once with PBS and fixed

(5) The p53-mediated cell cycle regulation is a potential mechanism for emodin-suppressing osteosarcoma cellsHeliyonMarch 15, 2024Qian Zhang, Shuli Hao, Guangyou Wei, Xiangyu Liu, Yang Miao°C for 20 min were used as positive controls for cell death [12]. Cells exposed to 5 μM Etoposide (ab120227, 1 mM stock prepared in DMSO, Abcam, Cambridge, UK) were used as the apoptosis-positive group. 2.5

(6) Influence of Rho/ROCK inhibitor Y-27632 on proliferation of equine mesenchymal stromal cellsFrontiers in Veterinary ScienceJune 6, 2023Michaela Melzer, Janina Burk, Deborah J. Guest, Jayesh DudhiaY-27632 (Tocris, Bioscience, Bistrol, United Kingdom), both in combination or with 10 μM etoposide (ab120227, Abcam, Cambridge, United Kingdom) which was used as positive control to induce senescence (27). Concentrations

(7) Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistanceCell reportsJuly 19, 2022Islam R, Mishra J, Polavaram NS, Bhattacharya S, Hong Z, Bodas S, Sharma S, Bouska A, Gilbreath T, Said AM, et al.#043–304 Xylazine,Patterson Veterinary,NDC 14043–700–50 Cisplatin,Teva Generics,NDC 0703–5747–11 Etoposide,Abcam,ab120227 Gibco RPMI 1640,ThermoFisher Scientific,11875–093 FBS,Sigma-Aldrich,F2442 BSA,Sigma-Aldrich,A7906–500G DPBS,Corning,21–031-CV Trypsin,ThermoFisher Scientific

(8) Inducing regulated necrosis and shifting macrophage polarization with anti-EMMPRIN antibody (161-pAb) and complement factorsJournal of leukocyte biologyAugust 1, 2021Hijaze N, Ledersnaider M, Simanovich E, Kassem S, Rahat MA.H2O2 (100 μM, 323381, Sigma‐Aldrich Corp. St. Louis, MO, USA) or by apoptosis using Etoposide (10 μM, ab120227, Abcam, Cambridge, United Kingdom). Alternatively, tumor cell death was induced by addition of 161‐pAb

(9) Tau affects P53 function and cell fate during the DNA damage responseCommunications biologyMay 19, 2020Sola M, Magrin C, Pedrioli G, Pinton S, Salvadè A, Papin S, Paganetti P.selection in 5 μg/mL puromycin for one to 2 weeks. Drug treatments Etoposide (100 mM stock in DMSO; ab120227, Abcam) treatment was followed by three washes with complete DMEM and cells were allowed to recover

(10) The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein CrosslinksCell ReportsJanuary 28, 2020Qianghua Hu et al.390238 PicoGreen,Thermo Fisher Scientific,Cat# P7589 MycoAlert,Lonza,Cat# LT07-218 Etoposide (ETO),Abcam,Cat# ab120227 Critical Commercial Assays,Critical Commercial Assays,Critical Commercial Assays GeneArt Seamless Cloning and Assembly Kit

(11) CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived NeuronsNeuronOctober 23, 2019Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, et al.Doxycycline hyclate,Sigma,Cat#D9891 Poly-L-ornithine hydrobromide,Sigma-Aldrich,Cat#P3655-50MG Etoposide,Abcam,Cat#ab120227 Essential 8 Medium,Thermo Fisher Scientific,Cat#A1517001 Matrigel Basement Membrane Matrix,Corning,Cat#356231 Y-27632 dihydrochloride

(12) Phosphorylation of nuclear Tau is modulated by distinct cellular pathwaysScientific reportsDecember 7, 2018Ulrich G, Salvadè A, Boersema P, Calì T, Foglieni C, Sola M, Picotti P, Papin S, Paganetti P.tetracycline incubation, C17.2 cells with inducible Tau expression were treated with 60 µM Etoposide (Abcam, ab120227; 100 mM stock in DMSO), 3 µM Vinblastine (Sigma-Aldrich, V1377; 11 mM stock in DMSO), or 60 nM Leptomycin

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Etoposide, Topoisomerase II inhibitor from Abcam

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Etoposide, Topoisomerase II inhibitor from Abcam

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