Proprotein Convertase 9/PCSK9 Antibody AF3888 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemProprotein Convertase 9/PCSK9 Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $499.00Supplier Page View Company Product Page
Catalog NumberAF3888
NCBI Gene AliasesPC9, FHCL3, FH3, HCHOLA3, NARC1, LDLCQ1, NARC-1
ApplicationsELISA,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry
HostSheep
Quantity100 ug (also 25 ug)
IsotypeIgG
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
TargetProprotein Convertase 9/PCSK9
ReactivityHuman
NCBI Full Gene Nameproprotein convertase subtilisin/kexin type 9
ClonalityPolyclonal
ImmunogenMouse myeloma cell line NS0-derived recombinant human PCSK9 isoform 1, Gln31-Gln692, Accession # Q8NBP7
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human PCSK9 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse PCSK9 is observed.

Sizes Available: 100 ug (also 25 ug)

Add to Compare List

R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by FerroptosisCellsDecember 23, 2022Alannan M, Fatrouni H, Trézéguet V, Dittrich-Domergue F, Moreau P, Siegfried G, Liet B, Khatib AM, Grosset CF, Badran B, et al.then incubated with each of the following specific primary antibodies: a sheep anti-PCSK9 (1 μg/mL, AF3888, R&D Systems, Minneapolis, MN, USA), ferroptosis antibody sampler kit (Cell signaling, 29650), rabbit

(2) Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver CancerCancersDecember 20, 2022Alannan M, Trézéguet V, Amoêdo ND, Rossignol R, Mahfouf W, Rezvani HR, Dittrich-Domergue F, Moreau P, Lacomme S, Gontier E, et al.Tween 20), then incubated with each of the following specific primary antibodies: sheep anti-PCSK9 (1 μg/mL, AF3888, R&D systems, Minneapolis, MN, USA), mouse anti-GAPDH HRP conjugated (1:10,000, BLE649203, BioLegend,

(3) Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuitsThe Journal of biological chemistryJuly 1, 2022Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, et al.and 2-beta-mercaptoethanol. The following antibodies were used: PCSK9 (1/200 dilution; catalog no.: AF3888; R&D Systems), diluted in Tris-buffered saline 0.1% Tween with 0.5% bovine serum albumin (BSA); LDLR

(4) PCSK9 is not secreted from mature differentiated intestinal cellsJournal of lipid researchJanuary 1, 2021Moreau F, Thédrez A, Garçon D, Ayer A, Sotin T, Dijk W, Blanchard C, Chadeuf G, Arnaud L, Croyal M, et al.monoclonal or polyclonal antibodies raised against either human PCSK9 (ab181142 from Abcam, Paris, France/AF3888 from R&D Systems), mouse/rat PCSK9 (AF3995 from R&D Systems), human apoB (AB742 from Merck Millipore),

(5) 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 CellsFrontiers in pharmacologyJanuary 1, 2018Li X, Guo J, Liang N, Jiang X, Song Y, Ou S, Hu Y, Jiao R, Bai W.

(6) Heparan sulfate proteoglycans present PCSK9 to the LDL receptorNature communicationsSeptember 11, 2017Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, Larsen T, Andersen CBF, Weyer K, Li JP, et al.AF3985, 1:1000), anti-syndecan-1 (R&D AF3190, 1:1000), and immunostainings: anti-PCSK9 (R&D Systems AF3888, 2 µg/ml), and fluorescent secondary antibodies (Invitrogen). Detailed information on our use of primary

(7) Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese RatsThe Journal of pharmacology and experimental therapeuticsJuly 1, 2017Estridge TB, Dey AB, Reidy C, Yu X, Zhang Y, Hartley M, Milligan PL, Jin N, Kowala MC, Leohr JK, et al.plates (Thermo Fisher Scientific) were coated with 100 ml anti-PCSK9 antibody (diluted 1:100, cat. no. AF3888; R&D Systems, Minneapolis, MN) overnight at 4°C. The plate was washed three times with phosphate-buffered

(8) Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and FunctionPloS oneJanuary 1, 2015DeVay RM, Yamamoto L, Shelton DL, Liang H.

(9) Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresisCirculation researchDecember 6, 2013Tavori H, Giunzioni I, Linton MF, Fazio S.

(10) Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptorThe Biochemical journalMay 1, 2009Duff CJ, Scott MJ, Kirby IT, Hutchinson SE, Martin SL, Hooper NM.bold indicate the site of mutation. Antibodies The affinity-purified anti-PCSK9 polyclonal antibody AF3888, raised against mature (aa 31–692) PCSK9, was from R&D Systems. The affinity-purified goat anti-PCSK9

(11) Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRnmAbsJanuary 1, 0001"Yang D, Giragossian C, Castellano S, Lasaro M, Xiao H, Saraf H, Hess Kenny C, Rybina I, Huang ZF, Ahlberg J, et al."serum samples were incubated with biotinylated and sulfo-labeled anti-PCSK9 antibody (R&D Systems Cat# AF3888) and then transferred to a MSD Gold streptavidin-coated microplate. Total (free and therapeutic antibody

Be the First to Write a Review!

Proprotein Convertase 9/PCSK9 Antibody

Proprotein Convertase 9/PCSK9 Antibody

Proprotein Convertase 9/PCSK9 Antibody

Proprotein Convertase 9/PCSK9 Antibody

Proprotein Convertase 9/PCSK9 Antibody

Proprotein Convertase 9/PCSK9 Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (11)

Reviews

Proprotein Convertase 9/PCSK9 Antibody from R&D Systems, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map