Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt ab120751 from Abcam

Product Specs
ItemThioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120751
Quantity500 mg
Purity0.97
TypeChemical
Molecule NameThioflavin T

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Website: http://www.abcam.com

(1) RIPK1 is essential for Herpes Simplex Virus-triggered ZBP1-dependent necroptosis in human cellsbioRxivFebruary 21, 2026Oluwamuyiwa T. Amusan, Shuqi Wang, Chaoran Yin, Heather S. Koehler, Yixun Li, Tencho Tenev, Rebecca Wilson, Benjamin Bellenie, Ting Zhang, Jian Wang, et al.of 1 M Tris-HCl (pH 8.0). For ThT fluorimetry, 50 μl ZBP1 complexes were incubated with 50 μM ThT (ab120751, Abcam) for 30 min at room temperature. ThT fluorescence was measured using The Spark Multimode Microplate

(2) Exenatide Once Weekly in the Treatment of Patients with Multiple System AtrophyAnnals of NeurologyJuly 29, 2025Nirosen Vijiaratnam, Christine Girges, Martin Wiegand, Claudia Ismail, Alexandra Lameirinhas, Alison Yarnall, Cameron Kirk, Silvia Del‐Din, Lynn Rochester, Christopher Kobylecki, et al.The sample was removed and the surface was washed 3 times with filtered PBS, before 5 μM ThT (Abcam; ab120751) was added. Imaging was carried out on a custom‐built TIRF microscope, described previously, 29 using

(3) DEAD-Box Helicase 6 Blockade in Brain-Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates NeurotoxicityMedComm (2020)April 24, 2025Xiaoxu Wang, Lu Dai, Na Wu, Donghui Wu, Xinyuan Wang, Xia Meng, Qilei Zhang, Jing Lu, Xiaoxin Yan, Jing Zhang, et al.were calculated using Biacore T200 evaluation software (GE, Sweden). 4.14 RT‐QuIC ThT [49, 50] (#ab120751; Abcam, USA) was diluted in phosphate‐buffered saline (pH 7.4) to a final concentration of 20 µM. A

(4) Amyloids in bladder cancer hijack cancer-related proteins and are positive correlated to tumor stageSci RepFebruary 5, 2025Diego Alem, César X. García-Laviña, Francisco Garagorry, Dardo Centurión, Joaquina Farias, Hany Pazos-Espinosa, María Noel Cuitiño-Mendiberry, Carolina Villadóniga, Susana Castro-Sowinski, Martín Fló, et al.Thermo Fisher Scientific) counterstains were included in some experiments. Thioflavin T (ThT, 5 mM in PBS, ab120751, Abcam) incubation was performed for 15 min at RT. Coverslips were mounted in ProLong Glass Antifade

(5) RIPK1 is required for ZBP1-driven necroptosis in human cellsPLoS biologyFebruary 1, 2025Amusan OT, Wang S, Yin C, Koehler HS, Li Y, Tenev T, Wilson R, Bellenie B, Zhang T, Wang J, et al.of 1 M Tris-HCl (pH 8.0). For ThT fluorimetry, 50 μl ZBP1 complexes were incubated with 50 μm ThT (ab120751, Abcam) for 30 min at room temperature. ThT fluorescence was measured using The Spark Multimode Microplate

(6) Pridopidine subtly ameliorates motor skills in a mouse model for vanishing white matterLife Science AllianceMarch 1, 2024Ellen Oudejans, Diede Witkamp, Gino V Hu-A-Ng, Leoni Hoogterp, Gemma van Rooijen-van Leeuwen, Iris Kruijff, Pleun Schonewille, Zeinab Lalaoui El Mouttalibi, Imke Bartelink, Marjo S van der Knaap, et al.et al, 2022). Counts were performed by researchers blinded to genotype and treatment. Thioflavin T (ab120751; Abcam) staining performed on deparaffinized mouse brain sections were performed as described for thioflavin

(7) Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregatesScience AdvancesNovember 17, 2023Rebecca S. Saleeb, Craig Leighton, Ji-Eun Lee, Judi O’Shaughnessy, Kiani Jeacock, Alexandre Chappard, Robyn Cumberland, Tianxiao Zhao, Sarah R. Ball, Margaret Sunde, et al.nitrogen and stored at −80°C. ThT preparation ThT stock solutions were prepared by diluting ThT (Abcam, ab120751) into neat ethanol to give a final concentration ~5 M. The solution was vortexed thoroughly, and a working

(8) Inflammatory ER stress responses dictate the immunopathogenic progression of systemic candidiasisThe Journal of clinical investigationSeptember 1, 2023Awasthi D, Chopra S, Cho BA, Emmanuelli A, Sandoval TA, Hwang SM, Chae CS, Salvagno C, Tan C, Vasquez-Urbina L, et al.protein aggregates, cells were labeled with the cell-permeable fluorescent dye ThT (Abcam, catalog ab120751; stock 50 mM in DMSO, final concentration 5 μM in PBS). The cells were resuspended in 200 μL ThT staining

(9) Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson’s DiseaseJournal of Parkinson's DiseaseJuly 25, 2023Linn Oftedal, Jodi Maple-Grødem, Ole-Bjørn Tysnes, Guido Alves, Johannes Lange2-(N-morpholino)ethanesulfonic acid (MES) buffer pH 5.5 (#M1503, Duchefa Biochemie), 10μM Thioflavin-T (#ab120751, Abcam), 5 mM zinc sulfate (#1.08883, Sigma-Aldrich), 0.1 mg/ml alpha-synuclein, and 15μl CSF were added

(10) Seed Amplification Assay as a Diagnostic Tool in Newly-Diagnosed Parkinson’s DiseaseJ Parkinsons DisJune 27, 2023Linn Oftedal, Jodi Maple-Grødem, Ole-Bjørn Tysnes, Guido Alves, Johannes Lange2-(N-morpholino)ethanesulfonic acid (MES) buffer pH 5.5 (#M1503, Duchefa Biochemie), 10μM Thioflavin-T (#ab120751, Abcam), 5 mM zinc sulfate (#1.08883, Sigma-Aldrich), 0.1 mg/ml alpha-synuclein, and 15μl CSF were added

(11) FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory CircuitryCell ReportsOctober 13, 2020James C. Sears, Kendal Broadiewas used following the manufacture protocol for fixed eukaryotic cells. For Thioflavin T (ThT; Abcam ab120751) labeling, acutely dissected brains were incubated in 100 mM ThT and DRAQ5 (Thermo Scientific 62254;

(12) Nifedipine Upregulates ATF6-α, Caspases -12, -3, and -7 Implicating Lipotoxicity-Associated Renal ER StressInternational Journal of Molecular SciencesApril 29, 2020Chiung-Chi Peng, Chang-Rong Chen, Chang-Yu Chen, Yen-Chung Lin, Kuan-Chou Chen, Robert Y. PengUSA), tauroursodeoxycholic acid (TUDCA, Focus Biomolecules, Plymouth Meeting, PA, USA), thioflavin T (ThT) (ab120751, Abcam, Cambridge, MA, USA): 20 ,70 -dichlorofluorescin diacetate (DCFDA) (Sigma-Aldrich, St. Louis,

(13) The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage DiseaseMolecular therapy : the journal of the American Society of Gene TherapyApril 8, 2020Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, et al.Bradford assay. 50 μg of homogenate were incubated for 5 min at room temperature with thioflavin T (ab120751, Abcam) prepared at 20 μM in water. Fluorescence emission at 485 nm (excitation at 450 nm) then was

(14) A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot StudyFrontiers in NeurologyNovember 26, 2019Sulette de Villiers, Janette Bester, Douglas B. Kell, Etheresia PretoriusFibrinogen was treated by addition of thioflavin T to a final concentration of 0.025 mmol/μl (Abcam, ab120751). Fibrin clots were prepared by addition of thrombin to the treated PPP. Clots were viewed under 63

(15) Isolation and Imaging of His- and RFP-tagged Amyloid-like Proteins from Caenorhabditis elegans by TEM and SIMBIO-PROTOCOLNovember 5, 2019Amberley D Stephens, Meng Lu, Gabriele S Kaminski Kaminski Schierlecatalog number: I5513) 21. HCl (Merck, catalog number: 84435) 22. Thioflavin T (Abcam, catalog number: ab120751) -important to use within shelf life Copyright Stephens et al., 2019 This article is distributed under

(16) Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by GlucosylceramideNeuronJanuary 3, 2018Zunke F, Moise AC, Belur NR, Gelyana E, Stojkovska I, Dzaferbegovic H, Toker NJ, Jeon S, Fredriksen K, Mazzulli JR.(PK),Thermo Fisher Scientific,Cat #17916 Thioflavine S,Sigma,Cat #T1892 Thioflavine T,Abcam,Cat #ab120751 ,, Critical Commercial Assays,Critical Commercial Assays,Critical Commercial Assays ,, Genomic DNA isolation kit

(17) Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory ProcessingFrontiers in cellular neuroscienceJanuary 1, 2017Marathe S, Jaquet M, Annoni JM, Alberi L.anti Hes5 (Abcam, cat. no. ab25374). Misfolded β-sheets were stained with Thioflavin-T (Abcam, cat.n. ab120751) at a concentration of 100 mM diluted in water, following the manufacturer's instructions. Nuclei were

(18) Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's diseaseActa neuropathologica communicationsJuly 1, 2016Brai E, Alina Raio N, Alberi L.anti-NF200, 1:500 (cat. no. 1178709; Boehringer Mannheim Biochimica, Germany). We also used Thioflavin T (ab120751; Abcam, UK) to stain the misfolded β sheets at a concentration of 100 mM diluted in water, following

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Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt from Abcam

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Thioflavin T, Fluorescent cell-permeable amyloid binding benzothiazole salt from Abcam

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