SB431542, ALK inhibitor ab120163 from Abcam

Product Specs
ItemSB431542, ALK inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120163
Quantity1 mg, 5 mg, 10 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule NameSB431542

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Abcam

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Cambridge Biomedical Campus

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United Kingdom

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Website: http://www.abcam.com

(1) Protocol for the generation of human medullary spinal trigeminal nucleus-like organoids and trigeminothalamic assembloidsSTAR ProtocJuly 14, 2026Wei Pang, Jinkui Zhu, Siyuan Chu, Yangfei XiangC060 Matrigel,BD,Cat# 354230 Y-27632,MCE,Cat# HY-10583 LDN193189,MCE,Cat# HY-12071A SB431542,Abcam,Cat# ab120163 CHIR99021,Stem Cell Technologies,Cat# 72054 BMP7,Life Technologies,Cat# PHC9544 PD325901,Selleck,Cat#

(2) Human amygdala-like telencephalic organoids model stress circuitry in assembloid systemsCell Stem CellJuly 2, 2026Woo Sub Yang, Mu Seog Choe, Cynthia Lo, Hui-Wen Liu, Yoon Mi Cho, Jonghun Kim, Ferdi Ridvan Kiral, Michael Scandura, Xiaona Lu, Kun-Yong Kim, et al.compound,Tissue-Tek,Cat# 4583 Penicillin/Streptomycin,Life Technologies,Cat# 15140-122 SB431542,Abcam,Cat# ab120163 VectaShield Mounting Medium,Vector Laboratories,Cat# H-1000-10 Y-27632,Stem Cell Technologies,Cat#

(3) Respiratory viral infections prime accelerated lung cancer growthCellMarch 11, 2026Wei Qian, Xiaoqin Wei, Andrew J. Barros, Xiangyu Ye, Haibo Zhang, Qing Yu, Samuel P. Young, Eric V. Yeatts, Yury Park, Chaofan Li, et al.CHIR 99021,Tocris Bioscience,Cat# 4423 BIRB 796,Tocris Bioscience,Cat# 5989 "SB431542, ALK inhibitor",Abcam,Cat# ab120163 Y-27632 Dihydrochloride,Selleckchem,Cat# S1049 Heparin sodium salt,Sigma,Cat# H3149 N-Acetyl-L-cysteine,Sigma,Cat#

(4) Parkinson's Disease Patient‐Specific Striatum Organoids Show Hallmarks of Increased InflammationMovement DisordersFebruary 11, 2026Kyriaki Barmpa, Claudia Saraiva, Alise Zagare, Mona Tuzza, Joseph Longworth, Elisa Zuccoli, Katrin Hufnagel, Florian Skwirblies, Ronny Schmidt, Dirk Brenner, et al.supplemented with 10 μM Ri, 2.5 μM Dorsomorphin (Sigma‐Aldrich, P5499) and 10 μM SB‐431542 (Abcam, ab120163). Spheroids were cultured in the same medium until D5, with Ri concentration decreasing to 10 μM on

(5) Generation of human pineal gland organoids with melatonin production for disease modelingCell stem cellJanuary 8, 2026Kiral FR, Yang WS, Iyilikci O, Lu X, Kim J, Choe MS, Lo C, Zhong M, Kim KY, Jiang YH, et al.PDL Prazosin,Tocris,Cat# 0623 Puromycin,Sigma,Cat# P8833 Retinoic acid,Sigma,Cat# R2625 SB431542,Abcam,Cat# ab120163 Stem cell factor (SCF),Stem Cell Technologies,Cat# 78062.1 StemSpan SFEM,Stem Cell Technologies,Cat#

(6) Radiofrequency regulates the BET-mediated pathways in radial glia differentiation in human cortical developmentCell ReportsOctober 28, 2025Bilal Cakir, Yoshiaki Tanaka, Mu Seog Choe, Ferdi Ridvan Kiral, Jonghun Kim, Nicola Micali, Young-Jin Kang, Bhushan Dharmadhikari, Benjamin Patterson, Woo Sub Yang, et al.07913 Accutase (100mL),Stem Cell Technologies,Cat# AT104 LDN-193189,Sigma,Cat# SML0559 SB431542,Abcam,Cat# ab120163 XAV939,Sigma,Cat# X3004 Purmorphamine,Stem Cell Biotech,Cat# 72204 Puromycin,Sigma,Cat# P8833 BDNF,Prepotech,Cat#

(7) The Parkinson's disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degenerationJ NeuroinflammationOctober 27, 2025Henry Kurniawan, Sarah L. Nickels, Alise Zagare, Elisa Zuccoli, Isabel Rosety, Gemma Gomez-Giro, Enrico Glaab, Jens C. SchwambornA4544-100G), 0.5 µM smoothened agonist (SAG, Stemcell Technologies 73412), 2.5 µM SB-431542 (Abcam, ab120163), and 0.1 µM LDN-193189 (Sigma, SML0559) for 2 days. From day 2 to 4, cells were cultured in patterning

(8) Pancreatic cancer cells escape T/NK cell immune surveillance through the expressional separation of CD58Journal for ImmunoTherapy of CancerSeptember 14, 2025Yalu Zhang, Huaijin Zheng, Ronghua Zhang, Jiayi Li, Sen Yang, Yuze Hua, Jorg Kleeff, Quan Liao, Qiaofei Liu(5 ng/mL; ab50336, Abcam, UK) was used to activate the TGF-β/Smad2/3 pathway, while SB431542 (20 µM; ab120163, Abcam, UK) was applied to inhibit TGF-β receptor signaling. Recombinant human CD58 (ab179975, Abcam,

(9) A scalable platform for EPSC-Induced MSC extracellular vesicles with therapeutic potentialStem Cell Res TherAugust 5, 2025Shixin Gong, Nan Li, Qinqing Peng, Feng Wang, Rulong Du, Boyang Zhang, Jian Wang, Le Han, Yu Zhang, Zemin Ning, et al.Stemcell Technologies, 72054), A83-01 (0.5µM, Santa Cruz Biotechnology, sc-203791 ), SB431542 (1µM, Abcam, ab120163 ), Y-27,632 (5µM, Abcam, ab120129) and Valproic acid (0.8mM, Selleck, S3944 ). On Day 6, cells were

(10) Brain organoid maturation and implantation integration based on electrical signals inputJournal of advanced researchJuly 1, 2025Li XH, Hu N, Chang ZH, Shi JX, Fan X, Chen MM, Bao SQ, Chen C, Zuo JC, Zhang XW, et al.72304 Accutase,Stem Cell Technologies,Cat# AT104 LDN-193189,Sigma,Cat# SML0559 SB431542,Abcam,Cat# ab120163 XAV939,Sigma,Cat# X3004 SHH,R&D Systems,Cat# 464-SH-200 purmorphamine,Stem Cell Biotech,Cat# 72204 BDNF,Prepotech,Cat#

(11) M2 macrophage co-culture overrides viscoelastic hydrogel mechanics to promote IL-6-dependent fibroblast activationCell BiomaterialsMay 27, 2025Leilani R. Astrab, Mackenzie L. Skelton, Steven R. Caliarireceptor (IL-6R),10 μg mL−1,Abcam (ab275982) SB431542,Small molecule,ALK5 receptor (TGFβlR),50 μM,Abcam (ab120163) Latrunculin A (LATA),Small molecule,Actin polymerization,5 μM,Abcam (ab144290) (±)-Blebbistatin,Small

(12) α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid ModelAdvanced ScienceApril 17, 2025Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, et al.NPM medium was additionally supplemented with 10 µm final concentration of SB431542 (Abcam, cat no. ab120163), 100 ng mL−1 Noggin (Stem Cell Technologies, cat no. 78060) and 4 µm CHIR99021 (Axon, cat no. CT 99021),

(13) Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid modelMolecular MedicineNovember 23, 2024Yiwen Yao, Felix Ritzmann, Sarah Miethe, Kathrin Kattler-Lackes, Betül Colakoglu, Christian Herr, Andreas Kamyschnikow, Michelle Brand, Holger Garn, Daniela Yildiz, et al.of Advanced DMEM/F12 medium (Thermo Fisher Scientific, 12634010) containing 10 µM SB431542 (Abcam, Ab120163), 3 µM CHIR99021 (Tocris, 4423), 1 µM BIRB796 (Tocris, 5989), 50 ng/mL human EGF (Gibco, PHG0313), 10

(14) Direct M2 macrophage co-culture overrides viscoelastic hydrogel mechanics to promote fibroblast activationbioRxivOctober 19, 2024Leilani R. Astrab, Mackenzie L. Skelton, Steven R. Caliarireceptor (IL6R),10 μg mL−1,Abcam (ab275982) SB431542,Small molecule,ALK5 receptor (TGFβ1R),50 μM,Abcam (ab120163) Latrunculin A (LAT-A),Small molecule,Actin polymerization,5 μM,Abcam (ab144290) (±)-Blebbistatin,Small

(15) Gene-level alignment of single-cell trajectoriesNature MethodsSeptember 19, 2024Dinithi Sumanaweera, Chenqu Suo, Ana-Maria Cujba, Daniele Muraro, Emma Dann, Krzysztof Polanski, Alexander S. Steemers, Woochan Lee, Amanda J. Oliver, Jong-Eun Park, et al.supplemented with ROCK inhibitor and SB blocker (TGF-β receptor kinase inhibitor SB- 431542; Abcam, ab120163) was added into the wells outside the inserts so that the cells sat at the air–liquid interface. The

(16) Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-βInternational Journal of Chronic Obstructive Pulmonary DiseaseJanuary 5, 2024Mei-Yu Lv, Ling-Ling Jin, Xi-Qiao Sang, Wen-Chao Shi, Li-Xia Qiang, Qing-Yan Lin, Shou-De Jinthe same amount of PBS. Mice in the ABSMSB group were administered (i.p.) with SB-431542 (10mg/kg; ab120163, Abcam) 2 hours before CSE.17,18 Mice sacrificed and specimens collected on Day 51. Cigarette extraction

(17) Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via TGF-βInt J Chron Obstruct Pulmon DisJanuary 5, 2024Mei-Yu Lv, Ling-Ling Jin, Xi-Qiao Sang, Wen-Chao Shi, Li-Xia Qiang, Qing-Yan Lin, Shou-De Jinthe same amount of PBS. Mice in the ABSMSB group were administered (i.p.) with SB-431542 (10mg/kg; ab120163, Abcam) 2 hours before CSE.17,18 Mice sacrificed and specimens collected on Day 51. Cigarette extraction

(18) Automated, High‐Throughput Phenotypic Screening and Analysis Platform to Study Pre‐ and Post‐Implantation Morphogenesis in Stem Cell‐Derived Embryo‐Like StructuresAdvanced ScienceJanuary 1, 2024Vinidhra Shankar, Clemens van Blitterswijk, Erik Vrij, Stefan Giselbrechtreceptor Activator,R&D Systems 4645‐RS‐025,100 ng mL−1 SB431542 (SB43),Tgfβ (ALK) Inhibitor,Abcam ab120163,10 µm PD0325901 (PD032),MEK/ERK Inhibitor,Bio‐Techne Sales corp 4192/10,1 µm PD98059 (PD98),Fgf/MAPK

(19) Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypesBrainNovember 2, 2023Maria O Levitin, Lettie E Rawlins, Gabriela Sanchez-Andrade, Osama A Arshad, Stephan C Collins, Stephen J Sawiak, Phillip H Iffland, Malin H L Andersson, Caleb Bupp, Emma L Cambridge, et al.cultured in feeder-free conditions as per published protocols.42,43 Dual-SMAD inhibition (SB431542, #ab120163, Abcam and LDN193189, #2092-5, Cambridge Bioscience) was used in a 10-day neural induction in the presence

(20) FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitroiScienceAugust 18, 2023Lau HH, Amirruddin NS, Loo LSW, Chan JW, Iich E, Krishnan VG, Hoon S, Teo AKK.Biotech,Cat#051-86 OSI-906,Selleckchem,Cat#S1091 Picropodophyllotoxin (PPP),Abcam,Cat#Ab144623 SB431542,Abcam,Cat#AB120163 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, "NEXTflex™

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SB431542, ALK inhibitor from Abcam

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SB431542, ALK inhibitor from Abcam

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