Camptothecin, DNA topoisomerase inhibitor ab120115 from Abcam

Product Specs
ItemCamptothecin, DNA topoisomerase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120115
Quantity50 mg, 250 mg
Molecule NameCamptothecin
TypeInhibitor, inhibitor
Purity0.98

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Mitotic DNA repair by TMEJ suppresses replication stress-induced nuclear envelope reassembly defectNat CommunOctober 3, 2025Guojun Ye, Yide He, Yihui Zhang, Dongchen Li, Fuhai Liu, Yi Li, Qinglian Ge, Qiong Guo, Shuya Han, Chunyu Song, et al.stress, unless otherwise stated. DNA damages were induced by Camptothecin (5 μM for 1 h, Abcam, Cat. #ab120115), Zeocin (50 μg/mL for 1 h, Thermo Fisher Scientific, Cat. #25005), or 10 Gy ionizing radiation. ATM

(2) Germline pathogenic variants in HIC1 DNA binding domains are associated with familial serrated polyposis syndromeInternational Journal of CancerSeptember 15, 2025Xavier Domínguez‐Rovira, Coral Arnau‐Collell, Gemma Gonfaus‐Ortiz, Gemma Llargués‐Sistac, Jenifer Muñoz, Ainara Llopis, Yasmin Soares de Lima, Cristina Herrera‐Pariente, Leticia Moreira, Teresa Ocaña, et al.48 h. Cells were stimulated with 500 nM (HT29) or 200 nM (hTERT RPE‐1) camptothecin (CPT) (cat. no. Ab120115, Abcam) for 60 min and collected for protein analysis. After DNA damage, cells were also allowed to

(3) SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent stateElifeFebruary 19, 2025Ruben Sebastian-Perez, Shoma Nakagawa, Xiaochuan Tu, Sergi Aranda, Martina Pesaresi, Pablo Aurelio Gomez-Garcia, Marc Alcoverro-Bertran, Jose Luis Gomez-Vazquez, Davide Carnevali, Eva Borràs, et al.topoisomerases To inhibit DNA topoisomerases, ESCs were treated with 500 nM of the topoisomerase I inhibitor CPT (ab120115, Abcam) and/or with 5 µM of the topoisomerase II inhibitor ICRF-193 (I4659, Sigma) for 12 hr. Immunostaining,

(4) SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent stateElifeFebruary 19, 2025Ruben Sebastian-Perez, Shoma Nakagawa, Xiaochuan Tu, Sergi Aranda, Martina Pesaresi, Pablo Aurelio Gomez-Garcia, Marc Alcoverro-Bertran, Jose Luis Gomez-Vazquez, Davide Carnevali, Eva Borràs, et al.topoisomerases To inhibit DNA topoisomerases, ESCs were treated with 500 nM of the topoisomerase I inhibitor CPT (ab120115, Abcam) and/or with 5 µM of the topoisomerase II inhibitor ICRF-193 (I4659, Sigma) for 12 hr. Immunostaining,

(5) PARP inhibition-associated heterochromatin confers increased DNA replication stress and vulnerability to ATR inhibition in SMARCA4-deficient cellsCell Death DiscovJanuary 28, 2025Kimiyoshi Yano, Megumi Kato, Syoju Endo, Taichi Igarashi, Ryoga Wada, Takashi Kohno, Astrid Zimmermann, Heike Dahmen, Frank T. Zenke, Bunsyo ShiotaniDarmstadt, Germany (CrossRef Funder ID: 10.13039/100009945). Camptothecin (CPT) was purchased from Abcam (ab120115). G9a/GLPi (UNC0642) was purchased from Selleck Chemicals (S7230). Mre11i (mirin) was purchased from

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Camptothecin, DNA topoisomerase inhibitor from Abcam

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Camptothecin, DNA topoisomerase inhibitor from Abcam

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