Forskolin, Adenylyl cyclase activator ab120058 from Abcam

Product Specs
ItemForskolin, Adenylyl cyclase activator
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120058
Quantity5 mg, 10 mg, 50 mg, 100 mg
Molecule NameForskolin
TypeActivator/Agonist

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) ApoE4 disrupts intracellular trafficking and iron homeostasis in a reproducible iPSC-based model of human brain endothelial cellsStem Cell ReportsSeptember 9, 2025Luisa Bell, Shane Clerkin, Sila Rizalar, Antoine Rizkallah, Nadine Stokar-Regenscheit, Xandor M. Spijkers, Nienke R. Wevers, Claire Simonneau, Angélique Augustin, Barbara Höllbacher, et al.(15070063, Gibco) and freshly supplemented with VEGF165 50 ng/mL (293-VE-010, R&D) and Forskolin 2 μM (ab120058, Abcam). On day 6 of culture, cells were replated in 10 cm dishes (1.2 million per dish) coated with

(2) Physiological role and mechanisms of action for a long noncoding haplotype regionCell ReportsJune 24, 2025Hong Xue, Manoj K. Mishra, Yong Liu, Pengyuan Liu, Michael Grzybowski, Rajan Pandey, Kristie Usa, Mark A. Vanden Avond, Niharika Bala, Abdel A. Alli, et al.21985023 BMP4,PeproTech (Gibco),Cat# 120-05-100UG VEGF,PeproTech (Gibco),Cat# 100-20-1MG Forskolin,Abcam,Cat# ab120058 PDGF-BB,PeproTech (Gibco),Cat# 100-14B-100UG Activin A,PeproTech (Gibco),Cat# 120-14E-500UG MEK-inhibitor

(3) Programmed death-ligand 1 regulates ameloblastoma growth and recurrenceInternational journal of oral scienceApril 16, 2025Zhang L, Lin H, Liang J, Liu X, Zhang C, Man Q, Li R, Zhao Y, Liu B.prostaglandin E2 (MCE, #HY-101952), 0.3 μmol/L CHIR 99021 (Sigma, #SML1046), 1 μmol/L forskolin (Abcam, #ab120058), 50 ng/mL R-spondin (R&D Systems, #3266-RS), and 25 ng/mL Noggin (PeproTech). To facilitate organoid

(4) Transcriptomic analysis of iPSC-derived endothelium reveals adaptations to high altitude hypoxia in energy metabolism and inflammationPLoS GenetFebruary 10, 2025Olivia A. Gray, David B. Witonsky, Jordan Jousma, Débora R. Sobreira, Alexander Van Alstyne, Ru-Ting Huang, Yun Fang, Anna Di Rienzotechnologies, 10639-011) supplemented with 200 ng/mL VEGF165 (PeproTech, 100-20) and 2 μM forskolin (Abcam, ab120058), and penicillin-streptomycin]. EC Induction Medium was refreshed on day 5, and on day 6 CD144+ cells

(5) Fully biologic endothelialized-tissue-engineered vascular conduits provide antithrombotic function and graft patencyCell Stem CellJanuary 2, 2025Jinkyu Park, Muhammad Riaz, Lingfeng Qin, Wei Zhang, Luke Batty, Saba Fooladi, Mehmet H. Kural, Xin Li, Hangqi Luo, Zhen Xu, et al.trypsin-EDTA,ThermoFisher,25300–054 CHIR-99021,Selleckchem,S2924 BMP4,Peprotech,120–05 VEGF-A,Peprotech,AF-100–20A Forskolin,Abcam,ab120058 2-Mercaptoethanol,Life technologies,21985023 Dynabeads™ CD31 Endothelial Cell,Invitrogen,11155D Gelatin,ThermoFisher,G2500–100G Dextran,Sigma-Aldrich,D5376 Endothelial

(6) DNA-PKcs inhibition improves sequential gene insertion of the full-length CFTR cDNA in airway stem cellsMolecular Therapy - Nucleic AcidsDecember 10, 2024Jacob T. Stack, Rachael E. Rayner, Reza Nouri, Carlos J. Suarez, Sun Hee Kim, Karen L. Kanke, Tatyana A. Vetter, Estelle Cormet-Boyaka, Sriram Vaidyanathanactivators and inhibitors was as follows: amiloride (10 μM, apical), forskolin (10 μM, bilateral; Abcam #ab120058), VX-770 (10 μM, apical; SelleckChem #S1144), CFTRinh-172 (20 μM, apical; Sigma Millipore #C2992), and

(7) Angiopoietin‐2 reverses endothelial cell dysfunction in progeria vasculatureAging CellOctober 18, 2024Sahar Vakili, Elizabeth K. Izydore, Leonhard Losert, Wayne A. Cabral, Urraca L. Tavarez, Kevin Shores, Huijing Xue, Michael R. Erdos, George A. Truskey, Francis S. Collins, et al.was changed to StemPro media (Life Technologies, 10639‐011) supplemented with 5 μM forskolin (Abcam, ab120058), and 100 ng/mL vascular endothelial growth factor (VEGF) (PeproTech, 100–20) for 2 days. On day 7,

(8) Red blood cell signaling is functionally conserved in Plasmodium invasioniScienceOctober 18, 2024James Jia Ming Yong, Xiaohong Gao, Prem Prakash, Jing Wen Ang, Soak Kuan Lai, Ming Wei Chen, Jason Jun Long Neo, Julien Lescar, Hoi Yeung Li, Peter R. PreiserScientific,BUF-204010X1L Isopropyl-β-d-thiogalactopyranoside (IPTG),Sigma,16758 HEPES,Sigma,H4034 Forskolin,Abcam,ab120058 PierceTM IP lysis buffer,Thermo Scientific,87788 Isopore polycarbonate membrane,Merck,GTTP04700 Nitrocellulose membranes

(9) Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastomaInternational journal of oral scienceFebruary 29, 2024Xiong G, Xie N, Nie M, Ling R, Yun B, Xie J, Ren L, Huang Y, Wang W, Yi C, et al.prostaglandin E2 (MCE, Cat#HY-101952), 0.3 μmol/L CHIR 99021 (Sigma, Cat#SML1046), 1 μmol/L forskolin (Abcam, Cat#ab120058), 50 ng/mL R-spondin (R&D Systems, Cat#3266-RS) and 25 ng/mL Noggin (PeproTech, Cat#120-10 C). To aid

(10) Adipocyte lipolysis protects mice against Trypanosoma brucei infectionNature MicrobiologyOctober 12, 2023Henrique Machado, Peter Hofer, Rudolf Zechner, Terry K. Smith, Luísa M. Figueiredoexplants were incubated for an additional hour with a similar medium containing 20 µM of forskolin (Abcam, ab120058). Up to five explants were used per AT depot. Next, FFA (C8 and longer) and glycerol concentrations

(11) Single-cell characterization of neovascularization using hiPSC-derived endothelial cells in a 3D microenvironmentStem Cell ReportsOctober 1, 2023Simon Rosowski, Caroline Remmert, Maren Marder, Misao Akishiba, Judith Bushe, Annette Feuchtinger, Alina Platen, Siegfried Ussar, Fabian Theis, Sandra Wiedenmann, et al.10639011) with VEGFA (200 ng/mL) (PeproTech, cat. no. 10-20-100) and forskolin (2 μM) (Abcam, cat. no. ab120058). Afterward, StemPro-34 with VEGFA (30 ng/mL) and FGF2 (30 ng/mL) (Miltenyi Biotech, cat. no. 130-093-838)

(12) Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenomaInternational Journal of Oral ScienceSeptember 7, 2023Xiuyun Xu, Jiaxiang Xie, Rongsong Ling, Shengqi Ouyang, Gan Xiong, Yanwen Lu, Bokai Yun, Ming Zhang, Wenjin Wang, Xiqiang Liu, et al.(MCE, Cat#HY-101952), 0.3 μmol·L−1 CHIR 99021 (Sigma, Cat#SML1046), 1 μmol·L−1 forskolin (Abcam, Cat#ab120058), 50 ng·mL−1 R-spondin (R&D Systems Cat#3266-RS) and 25 ng·mL−1 Noggin (PeproTech, Cat#120-10 C). The

(13) Unlocking the Role of Endothelial MPL Receptor and JAK2V617F Mutation: Insights into Cardiovascular Dysfunction in MPNs and CHIPbioRxiv : the preprint server for biologyJuly 13, 2023Zhang H, Kafeiti N, Lee S, Masarik K, Zheng H, Zhan H.200ng/mL Vascular Gndothelial Growth Factor (VEGF)-165 (Cat. 100–20, Peprotech) and 2μM Forskolin (Cat. ab120058, Abcam), at ~0.3ml of medium per cm2 of cultured area. Day 6–7: cells were dissociated using Accutase

(14) Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotoninBioscience reportsApril 26, 2023Fernando SJA, Wang Q, Hay DL, Bathgate RAD, Shepherd PR, Lee KL.demonstrated to be similar to the published activity [18]. Other chemicals used were forskolin (Abcam, U.K. #ab120058) 3-isobutyl-1-methylxanthine (IBMX, Sigma Aldrich, U.S.A. #I5879) and pertussis toxin (Abcam #ab124299).

(15) FOSL1 promotes tumor growth and invasion in ameloblastomaFrontiers in OncologySeptember 15, 2022Gan Xiong, Shengqi Ouyang, Nan Xie, Jiaxiang Xie, Wenjin Wang, Chen Yi, Ming Zhang, Xiuyun Xu, Demeng Chen, Cheng Wanghuman FGF 10 (PeproTech, 100-26-5), 0.3 μmol/L CHIR 99021 (Sigma, SML1046), 1 μmol/L forskolin (Abcam, ab120058), 50 ng/ml R-spondin (R&D Systems, 3266-RS), 10 μmol/L Rho-associated kinase (ROCK) inhibitor Y-27632

(16) Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminalsNeuronAugust 17, 2022Monday HR, Kharod SC, Yoon YJ, Singer RH, Castillo PE.,Chemical Synthesis and Drug Supply Program of the National Institute of Mental Health,N/A Forskolin,Abcam,Cat#ab120058 AM251,Abcam,Cat#ab120088 DCG-IV,Tocris Bioscience,Cat#0975 MPEP,Tocris Bioscience,Cat#1212 LY367385,Tocris Bioscience

(17) Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growthNature communicationsFebruary 3, 2022Miete C, Solis GP, Koval A, Brückner M, Katanaev VL, Behrens J, Bernkopf DB.(C7897), guanabenz (GBZ, G110)48, and UK 14,304 (U104) were obtained from Sigma-Aldrich, and forskolin (ab120058) and H-89 (ab143787) from Abcam. Genetically engineered cell lines To generate U2OS cells stably expressing

(18) CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillanceCell stem cellSeptember 2, 2021Wang C, Li Y, Jia L, Kim JK, Li J, Deng P, Zhang W, Krebsbach PH, Wang CY.Cat#HY-101952), 0.3 μmol/L CHIR 99021 (Sigma-Aldrich, Cat#SML1046), 1 μmol/L Forskolin (Abcam, Cat#ab120058), 50ng/ml R-spondin (R&D Systems, Cat#3266-RS), 25ng/ml Noggin (PeproTech, Cat#120-10C), and 10 μmol/L

(19) Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOSAging cellJuly 1, 2021Gete YG, Koblan LW, Mao X, Trappio M, Mahadik B, Fisher JP, Liu DR, Cao K.cultured in StemPro media (Life Technologies, 10639‐011) supplemented with forskolin, 5 μM (Abcam, ab120058), and vascular endothelial growth factor (VEGF165) 100 ng/ml (PeproTech, 100–20) for two days. iPSC‐ECs

(20) Differentiation and characterization of human iPSC-derived vascular endothelial cells under physiological shear stressSTAR ProtocolsJune 18, 2021Nadia O. Abutaleb, George A. Truskeyinhibitor),BioVision,1596 Accutase cell detachment solution,Innovative Cell Technologies,AT104 Forskolin,Abcam,ab120058 Human BMP4,PeproTech,120-05ET CHIR99021,Cayman Chemical,13122 SB431542 (TGF-β inhibitor),Stem Cell Technologies

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Forskolin, Adenylyl cyclase activator from Abcam

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Forskolin, Adenylyl cyclase activator from Abcam

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