SP600125, JNK inhibitor ab120065 from Abcam

Product Specs
ItemSP600125, JNK inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120065
Quantity10 mg, 50 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule Name1,9-Pyrazoloanthrone

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(1) CREB2 Functions as a Central Mediator of Oxidative Neuronal Death Triggered by Microglial Glutamate Release Under Neuroinflammatory ConditionsCellular and Molecular NeurobiologyFebruary 13, 2026Uk Yeol Moon, Young Eun Kim, Huu Dat Nguyen, Hye Joung Choiwere prepared as concentrated stock solutions, including SP600125 (SP; 20 mM in DMSO; Abcam, cat. no. ab120065), SB203580 (SB; 20 mM in DMSO; Sigma, cat. no. S8307), U0126 (MEK1/2 inhibitor; 10 mM in DMSO; Cell Signaling Technology

(2) Transcriptomic-Driven Drug Repurposing Reveals SP600125 as a Promising Drug Candidate for the Treatment of Glial-Mesenchymal Transition in GlioblastomaInt J Mol SciOctober 7, 2025Kirill V. Odarenko, Marina A. Zenkova, Andrey V. Markovrecombinant TGF-β1 (CYT-716) was purchased from ProSpec-Tany TechnoGene Ltd. (Ness-Ziona, Israel). SP600125 (ab120065) was obtained from Abcam (Waltham, MA, USA), dissolved in DMSO at a concentration of 10 mM, and stored

(3) PARP15 Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy–Associated Systemic Capillary Leak Syndrome)Arteriosclerosis, Thrombosis, and Vascular BiologyDecember 1, 2024Eunice C. Chan, Ararat J. Ablooglu, Chandra C. Ghosh, Abhishek Desai, Niccole Schaible, Xiuying Chen, Ming Zhao, M. Renee Olano, Sundar Ganesan, Justin B. Lack, et al.(Cat# TP321040), and Ms PKCζ (CAT# MR227620) were purchased from Origene. SP100625 (JNK inhibitor, Cat# ab120065), PF573228 (FAK inhibitor, Cat# ab273523), and SB203580 (p38 inhibitor, Cat# ab120162) were purchased

(4) Neuroprotective effects of Gastrodia elata Blume on promoting M2 microglial polarization by inhibiting JNK/TLR4/T3JAM/NF-κB signaling after transient ischemic stroke in ratsFrontiers in PharmacologySeptember 25, 2024Shang-Chih Huang, Hui-Chi Huang, Wen-Ling Liao, Shung-Te Kao, Chin-Yi Chengadministered intracerebroventricularly with 10 μL of 1% DMSO or 10 μL of SP600125 solution (2 mM in 1% DMSO, ab120065, Abcam, Waltham, MA, United States) through a burr hole in the right side of the skull using a microsyringe

(5) Southern rice black-streaked dwarf virus induces incomplete autophagy for persistence in gut epithelial cells of its vector insectPLoS pathogensJanuary 1, 2023Zhang L, Liu W, Wu N, Wang H, Zhang Z, Liu Y, Wang X.IR0010), 3-methyladenine (3-MA) (Solarbio, IM0190), anisomycin (TargetMol, T6758), SP600125 (Abcam, AB120065). Recombinant plasmid construction Atg3, Atg8 and Atg12 from WBPH were amplified by specific primers

(6) CPEB1 regulates the inflammatory immune response, phagocytosis, and alternative polyadenylation in microgliaGliaOctober 1, 2022Maria P. Ivshina, Heleen M. van 't Spijker, Suna Jung, Sithara Raju Ponny, Dorothy P. Schafer, Joel D. Richterof which were treated with LPS, were incubated with vehicle (DMSO) or inhibitors of JNK (SP600125, AB120065, ABCAM; AS601245, AB145194, ABCAM), p38 (Dormapimod, AB142166, ABCAM; SB202190, AB120638, ABCAM), ERK

(7) Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancerWorld journal of gastroenterologyAugust 28, 2022Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, et al.(JNK) signaling pathway, NUGC4 and MKN45 cells were incubated with the JNK inhibitor SP600125 (10µm, ab120065, Abcam) according to manufacturer’s instructions. The cells were divided into 3 groups: control, ANO5

(8) Exenatide exerts a neuroprotective effect against diabetic cognitive impairment in rats by inhibiting apoptosis: Role of the JNK/c‑JUN signaling pathwayMolecular Medicine ReportsFebruary 2, 2022Gengyin Wang, Zongquan Zhao, Bo Ren, Wu Yu, Xudong Zhang, Jiang Liu, Liping Wang, Daowen Si, Meiliu Yangto the protective effects of exenatide in DM using a specific inhibitor of JNK (SP600125; cat. no. ab120065; Abcam). The rats were divided into four groups (n=5 rats/group): The DM group, the SP600125 + DM (SP

(9) Operation of the Atypical Canonical Bone Morphogenetic Protein Signaling Pathway During Early Human OdontogenesisFrontiers in physiologyJanuary 1, 2022Hu X, Lin C, Ruan N, Huang Z, Zhang Y, Hu X.experiments, dorsomorphin (Sigma, P5499), SB203580 (CST, 5633), U0126 (CST, 9903), and SP600125 (Abcam, ab120065) were added into the medium at the final concentration of 20 μM. Dimethyl sulfoxide (DMSO) (Sigma, 76314)

(10) MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagyMolecular medicine reportsDecember 1, 2021Lan CN, Cai WJ, Shi J, Yi ZJ.µmol/l) of U0126 (an ERK inhibitor; Abcam; cat. no. ab120241), SP600125 (a JNK inhibitor; Abcam; cat. no. ab120065) or SB203580 (a p38 inhibitor; Abcam; cat. no. ab120162), respectively, once a day for 3 days. All animals

(11) Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoidsAging cellSeptember 1, 2021Aguado J, Chaggar HK, Gómez-Inclán C, Shaker MR, Leeson HC, Mackay-Sim A, Wolvetang EJ.Lonza). For JNK and mitochondrial ROS inhibition, cells were treated with 20 μM SP600125 (Abcam, cat. # ab120065) and 100 nM MitoQ (MCE, cat. # HY‐100116A), respectively, for 10 days. For ATM inhibition, cells were

(12) Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradationNature communicationsJune 29, 2021Lin CC, Shen YR, Chang CC, Guo XY, Young YY, Lai TY, Yu IS, Lee CY, Chuang TH, Tsai HY, et al.(Irvine, CA), respectively. The IL-1β (#AF-401-NA, 1:2,000) antibodies and SP600125 (JNK inhibitor, #ab120065) were purchased from Abcam (Cambridge, UK) and R&D Systems (Minneapolis, MN). Antibodies against Regnase-1

(13) Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathwayMolecular medicine (Cambridge, Mass.)May 30, 2021Hao D, Li Y, Shi J, Jiang J.70% confluency. In addition, Anisomycin (4 µM, JNK activator) and SP600125 (JNK inhifbitor, 10 µM, ab120065, Abcam) were introduced for cell treatment (Chen et al. 2020). Cells in vitro were assigned into the

(14) Co-Exposure of Cardiomyocytes to IFN-γ and TNF-α Induces Mitochondrial Dysfunction and Nitro-Oxidative Stress: Implications for the Pathogenesis of Chronic Chagas Disease CardiomyopathyFrontiers in immunologyJanuary 1, 2021Nunes JPS, Andrieux P, Brochet P, Almeida RR, Kitano E, Honda AK, Iwai LK, Andrade-Silva D, Goudenège D, Alcântara Silva KD, et al.(W4262) were purchased from Sigma-Aldrich. Inhibitors of MEK1 and MEK2 PD98059 (ab120234), JNK SP600125 (ab120065) and MAPK SB202190 (ab120638) were purchased from Abcam. Reagents were dissolved in DMSO or water (Metformin

(15) TGF‑β1‑induced autophagy activates hepatic stellate cells via the ERK and JNK signaling pathwaysInternational Journal of Molecular MedicineNovember 3, 2020Jing Zhang, Na Jiang, Jian Ping, Lieming XuPD98059 (cat. no. ab120234; Abcam), 10 µM SB203580 (cat. no. ab120162; Abcam) or 10 µM SP600125 (cat. no. ab120065; Abcam) for 1 h, followed by treatment with or without 10 ng/ml TGF-β1 for varying durations (2, 4,

(16) The natural alkaloid Jerantinine B has activity in acute myeloid leukemia cells through a mechanism involving c-JunBMC cancerJuly 7, 2020Alhuthali HM, Bradshaw TD, Lim KH, Kam TS, Seedhouse CH.N-Acetyl-L-Cysteine (NAC) and SP600125 JNK inhibitor (JNKI) were purchased from Sigma (A7250) and Abcam (ab120065) respectively. Further dilutions were made in cell culture medium. Assessment of DNA damage response

(17) Long-term adenosine A1 receptor activation-induced sortilin expression promotes α-synuclein upregulation in dopaminergic neuronsNeural regeneration researchApril 1, 2020Lv YC, Gao AB, Yang J, Zhong LY, Jia B, Ouyang SH, Gui L, Peng TH, Sun S, Cayabyab FS.(Invitrogen). Cells were simultaneously co-incubated with CPA alone or with 10 μM SP600125 (JNK inhibitor; ab120065, Abcam) for 12 hours. A Dual-Luciferase Assay Kit (Promega) was used to assess luciferase activities,

(18) Sevoflurane Inhibits Proliferation and Invasion of Human Ovarian Cancer Cells by Regulating JNK and p38 MAPK Signaling PathwayDrug Design, Development and TherapyDecember 31, 2019Kai Kang, Yue Wangp38 inhibitor SB203580 (20 μM, ab120162, Abcam, Cambridge, MA, USA) or JNK inhibitor SP600125 (10 μM, ab120065, Abcam) according to the manufacturer’s instructions. Brieﬂy, the conﬂuent SKOV3 cell lines were pre-incubated

(19) c‑Jun N‑terminal kinase/transforming growth factor‑β/Smad3 pathway: Is it associated with endoplasmic reticulum stress‑mediated renal interstitial fibrosis?Molecular medicine reportsJuly 1, 2019Liu Y, Shen P, Zhou Y, Tang L, Chai H.were obtained from Sigma‑Aldrich (Merck KGaA, Darmstadt, Germany). SP600125 (a JNK inhibitor, cat. no. ab120065) and antibody against phosphorylated (p)‑Smad3 (cat. no. ab52903) were obtained from Abcam (Cambridge,

(20) Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal ApoptosisFrontiers in neuroscienceJanuary 1, 2019Dong H, Ye X, Zhong L, Xu J, Qiu J, Wang J, Shao Y, Xing H.Caspase-Glo® 3/7 Assay Systems (Promega, G8090) according to the operating instructions. Chemicals SP600125 (Abcam, ab120065), diallyl tetrasulfide (DSA4) (Abcam, ab143603), staurosporine (STS) (Cell Signaling Technology, #9953),

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SP600125, JNK inhibitor from Abcam

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SP600125, JNK inhibitor from Abcam

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